Comprehensive Information

Detailed Information (Experimental Results)

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Database ID14
UniProt ID A1JUC4 
Name Putative targeted effector protein kinase
Type Type III secretion system effector (T3SE)
Gene Name YEP0081
Organism Yersinia enterocolitica serotype O:8 / biotype 1B
Gene Ontology Terms GO:0005524;GO:0004674
Function -
Sequence MKIMGTMSPSISLAKAHERISKHWQNPVGELNIEGKRYRIIDNQVLRLNPHSGFSLFREGVGKIFSGKMFSFSIARNLTDTLHAAQKTTSQELRSDIPNALSNLFGAKPQTELPLGWKGKPLSGAPDLEGMRVAETDKFAEGESHISIIETKDKQRLVAKIERSIAEGHLFAELEAYKHIYKTAGKHPNLANVHGMAVVPYGNRKEEALLMDEVDGWRCSDTLRSLADSWKQGKINSEAYWGTIKFIAHRLLDVTNHLAKAGIVHNDIKPGNVVFDRASGEPVVIDLGLHSRSGEQPKGFTESFKAPELGVGNLGASEKSDVFLVVSTLLHGIEGFEKDPEIKPNQGLRFITSEPAHVMDENGYPIHRPGIAGVETAYTRFITDILGVSADSRPDSNEARLHEFLSDGTIDEESAKQILKDTLTGEMSPLPTDVRRITPKKLRELSDLLRTHLSSAATKQLDMGVVLSDLDTMLVALDKAEREGGVDKDQLKSFNSLILKTYSVIGAYIKGREGDTKSSSTEVSPYHRSNFMLSIVEPSLQRIQKHLDQTHSFSDIGSLMRAHKHLETLLEVLVTLSQQGQPVSSETYSFLNRLAEAKVTLSQQLNTLQQQQESAKAQLSILINRSGSWADVARQSLQRFDSTRPVVKFGTEQYTAIHRQMMAAHAAITLQEVSEFTDDMRNFTADSIPLLIQLGRSSLMDEHLVEQREKLRELTTIAERLNRLEREWM
Length 729  amino acids
Reference 24391954
IBS
There is no IBS picture for this protein entry.
Sequence Alignment:

Protein Structure (Experimental Results)

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PDB Accession Method Resolution Chain Structure Review
Sorry. There is no result for this protein entry.

Disorder Prediction (Computational Results)

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Start End Sequence
360 361 DE
292 306 RSGEQPKGFTESFKA
187 188 HP
391 403 DSRPDSNEARLHE
149 152 IETK
1 18 MKIMGTMSPSISLAKAHE
480 489 AEREGGVDKD
578 619 QQGQPVSSETYSFLNRLAEAKVTLSQQLNTLQQQQESAKAQL
84 103 AAQKTTSQELRSDIPNALSN
337 343 EKDPEIK
405 463 LSDGTIDEESAKQILKDTLTGEMSPLPTDVRRITPKKLRELSDLLRTHLSSAATKQLDM
105 144 FGAKPQTELPLGWKGKPLSGAPDLEGMRVAETDKFAEGES
512 527 REGDTKSSSTEVSPYH
540 556 LQRIQKHLDQTHSFSDI
700 729 MDEHLVEQREKLRELTTIAERLNRLEREWM

Disorder Picture (Computational Results)

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Kinase-specific Phosphorylation Sites (Computational Results)

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Position Code Kinase Peptide Score Cutoff
55 S Other/NEK/NEK11 LNPHSGFSLFREGVG 11 8.933
8 S CMGC/MAPK/ERK/Erk2 MKIMGTMSPSISLAK 15.889 4.61
279 S TKL/LISK/LIMK NVVFDRASGEPVVID 14 6
524 S Atypical/PIKK/FRAP KSSSTEVSPYHRSNF 13 8.145
438 T CMGC/DYRK/DYRK2 PTDVRRITPKKLREL 13.222 7.053
577 S Atypical/PIKK/ATR/ATR LEVLVTLSQQGQPVS 11.023 5.038
600 T Other/TTK/TTK RLAEAKVTLSQQLNT 59.727 47.968
414 S CK1/CK1/CK1-D/CSNK1D DGTIDEESAKQILKD 18.6 8.142
684 T Other/NEK/NEK11 TDDMRNFTADSIPLL 16 8.933
8 S CMGC/MAPK/ERK/Erk4 MKIMGTMSPSISLAK 11.667 5.7
677 T Other/NEK/NEK11 LQEVSEFTDDMRNFT 14 8.933
520 S CAMK/MAPKAPK/MNK/MNK1 EGDTKSSSTEVSPYH 11 8.333
66 S Other/NEK/NEK11 EGVGKIFSGKMFSFS 12 8.933
438 T CMGC/CDK/CDK2/CDC28 PTDVRRITPKKLREL 18.361 9.411
71 S STE/STE20/PAKA/PAK3 IFSGKMFSFSIARNL 11.867 5.9
438 T AGC/PKG/PRKG1 PTDVRRITPKKLREL 11.8 6.847
674 S CMGC/CK2 AITLQEVSEFTDDMR 12.691 7.389
409 T CK1/CK1/CK1-D/CSNK1D HEFLSDGTIDEESAK 14.6 8.142
422 T STE/STE20/TAO/TAOK1 AKQILKDTLTGEMSP 11 6.1
12 S CAMK/MAPKAPK/MK5 GTMSPSISLAKAHER 11.545 6.633
539 S AGC/PKC/PKCa/PRKCB MLSIVEPSLQRIQKH 14.914 8.434
428 S CAMK/MAPKAPK/MK5 DTLTGEMSPLPTDVR 13.818 6.633
379 T Other/TTK/TTK AGVETAYTRFITDIL 48.636 47.968
144 S CK1/CK1/CK1-D/CSNK1D DKFAEGESHISIIET 15.85 8.142
279 S TKL/LISK/LIMK/LIMK1 NVVFDRASGEPVVID 14 6
8 S CMGC/MAPK MKIMGTMSPSISLAK 11.681 4.55
428 S Atypical/PIKK/FRAP DTLTGEMSPLPTDVR 11.611 8.145
428 S CAMK/MAPKAPK/MK5/MAPKAPK5 DTLTGEMSPLPTDVR 13.818 6.633
438 T CMGC/MAPK/ERK/Erk4 PTDVRRITPKKLREL 11.667 5.7
524 S CMGC/MAPK/ERK/Erk1 KSSSTEVSPYHRSNF 14.299 10.326
52 S Other/NEK/NEK11 VLRLNPHSGFSLFRE 25 8.933
628 S AGC/PKC/PKCi ILINRSGSWADVARQ 11.438 7.442
21 S STE/STE20/MST/MST1 AKAHERISKHWQNPV 16.516 2.612
79 T CAMK/MAPKAPK/MK5/MAPKAPK5 FSIARNLTDTLHAAQ 16.909 6.633
674 S CAMK/MAPKAPK/MK5/MAPKAPK5 AITLQEVSEFTDDMR 11.545 6.633
81 T STE/STE20/TAO/TAOK1 IARNLTDTLHAAQKT 11 6.1
428 S CMGC/MAPK/ERK/Erk1 DTLTGEMSPLPTDVR 22.701 10.326
317 S Other/CDC7/CDC7 GVGNLGASEKSDVFL 12.667 9.583
614 S Other/CDC7/CDC7 TLQQQQESAKAQLSI 15.333 9.583
607 T Other/TTK/TTK TLSQQLNTLQQQQES 56.727 47.968
438 T STE/STE20/PAKA PTDVRRITPKKLREL 15.733 6.397
71 S AGC/PKN/PKN1 IFSGKMFSFSIARNL 13 5.283
552 S CAMK/CAMKL KHLDQTHSFSDIGSL 13.521 6.355
524 S CMGC/MAPK/p38/HOG1 KSSSTEVSPYHRSNF 13.2 7.46
81 T Other/NEK IARNLTDTLHAAQKT 12.964 4.27
438 T STE/STE20/MST/MST1 PTDVRRITPKKLREL 23.935 2.612
88 T Other/AUR/AurC TLHAAQKTTSQELRS 11.5 6.434
614 S Other/CDC7 TLQQQQESAKAQLSI 15.333 9.583
636 S Other/AUR/AurB WADVARQSLQRFDST 13.037 7.092
577 S CAMK/MAPKAPK/MNK LEVLVTLSQQGQPVS 12.444 5.685
628 S CAMK/CAMKL/CHK1 ILINRSGSWADVARQ 12.655 8.03
8 S CMGC/CDK/CDK5 MKIMGTMSPSISLAK 17.717 6.616
575 T Other/TTK/TTK TLLEVLVTLSQQGQP 58.364 47.968
607 T STE/STE20/YSK TLSQQLNTLQQQQES 11 6.05
519 S Atypical/PDHK/PDHK/PDK1 REGDTKSSSTEVSPY 19.73 2.714
424 T STE/STE7/MEK3/MAP2K6 QILKDTLTGEMSPLP 11.143 5.333
472 T Other/TTK/TTK VVLSDLDTMLVALDK 51.364 47.968
438 T CMGC/CDK/CDK2/CDK2 PTDVRRITPKKLREL 19.503 6.826
79 T STE/STE7/MEK1/MAP2K2 FSIARNLTDTLHAAQ 11 7
524 S CMGC/CDK/CDK5/CDK5 KSSSTEVSPYHRSNF 25.259 7.867
406 S CMGC/CK2 ARLHEFLSDGTIDEE 11.084 7.389
6 T Other/PLK **MKIMGTMSPSISL 12.558 8.093
438 T CMGC/CDK/CDC2/CDK1 PTDVRRITPKKLREL 12.801 4.168
519 S AGC/PKC/PKCa/PRKCB REGDTKSSSTEVSPY 12.172 8.434
328 T STE/STE20/MSN/MINK1 DVFLVVSTLLHGIEG 11 7
438 T CMGC/CDK/CDK5/CDK5 PTDVRRITPKKLREL 18.333 7.867
6 T CK1/VRK/VRK2 **MKIMGTMSPSISL 23.75 4
521 T CK1/CK1/CK1-D/CSNK1D GDTKSSSTEVSPYHR 18.9 8.142
524 S CMGC/MAPK/p38/MAPK11 KSSSTEVSPYHRSNF 11 5.425
181 Y TK/Axl/MER LEAYKHIYKTAGKHP 12.5 11.588
519 S CK1/CK1/CK1-D/CSNK1D REGDTKSSSTEVSPY 16.4 8.142
8 S CMGC/MAPK/JNK/JNK2 MKIMGTMSPSISLAK 29.529 6.118
428 S CMGC/CDK/CDK5 DTLTGEMSPLPTDVR 14.727 6.616
716 T CK1 EKLRELTTIAERLNR 18.993 5.313
424 T AGC/GRK QILKDTLTGEMSPLP 11.483 6.103
81 T STE/STE20/TAO IARNLTDTLHAAQKT 11 6.1
12 S CAMK/MAPKAPK/MK5/MAPKAPK5 GTMSPSISLAKAHER 11.545 6.633
438 T AGC/PKA/PKACB PTDVRRITPKKLREL 12.333 4.25
71 S CAMK/CAMKL IFSGKMFSFSIARNL 13.618 6.355
715 T CAMK/MAPKAPK/MK5 REKLRELTTIAERLN 11.545 6.633
589 S AGC/PKN/PKN1 PVSSETYSFLNRLAE 11.333 5.283
10 S CK1/VRK/VRK2 IMGTMSPSISLAKAH 15.5 4
422 T STE/STE20/TAO AKQILKDTLTGEMSP 11 6.1
8 S CMGC/MAPK/p38/HOG1 MKIMGTMSPSISLAK 12 7.46
508 Y TK/PDGFR/KIT TYSVIGAYIKGREGD 11.625 8.15
438 T CMGC/MAPK/ERK/Erk1 PTDVRRITPKKLREL 16.174 10.326
715 T CAMK/MAPKAPK/MK5/MAPKAPK5 REKLRELTTIAERLN 11.545 6.633
352 T CAMK/MAPKAPK/MK5/MAPKAPK5 NQGLRFITSEPAHVM 11.455 6.633
328 T STE/STE20/MSN/TNIK DVFLVVSTLLHGIEG 11 7
8 S CK1/VRK/VRK2 MKIMGTMSPSISLAK 18.75 4
12 S CK1/VRK/VRK2 GTMSPSISLAKAHER 14.75 4
428 S CMGC/MAPK/p38/HOG1 DTLTGEMSPLPTDVR 12 7.46
424 T TKL/MLK QILKDTLTGEMSPLP 15.08 7.138
697 S AGC/PKC/PKCa/PRKCB LLIQLGRSSLMDEHL 17.172 8.434
392 S CMGC/CK2 ILGVSADSRPDSNEA 12.062 7.389
614 S AGC/PKC/PKCi TLQQQQESAKAQLSI 11.312 7.442
414 S Other/CDC7 DGTIDEESAKQILKD 15.333 9.583
687 S AGC/PKC/PKCa/PRKCB MRNFTADSIPLLIQL 12.052 8.434
472 T CK1/CK1/CK1-D/CSNK1D VVLSDLDTMLVALDK 11.9 8.142
458 T Other/TTK/TTK THLSSAATKQLDMGV 48 47.968
376 T Other/CDC7 PGIAGVETAYTRFIT 12.333 9.583
220 S Other/Wnk/Wnk4 EVDGWRCSDTLRSLA 12.333 4.95
12 S CK1 GTMSPSISLAKAHER 11.597 5.313
8 S CMGC/MAPK/ERK/Erk1 MKIMGTMSPSISLAK 22.403 10.326
79 T CAMK/MAPKAPK/MK5 FSIARNLTDTLHAAQ 16.909 6.633
376 T Other/CDC7/CDC7 PGIAGVETAYTRFIT 12.333 9.583
222 T STE/STE20/TAO/TAOK1 DGWRCSDTLRSLADS 11 6.1
628 S CAMK/MAPKAPK ILINRSGSWADVARQ 19.481 6.36
642 S CAMK/CAMKL/CHK1 QSLQRFDSTRPVVKF 14.379 8.03
524 S CMGC/CDK/CDK5 KSSSTEVSPYHRSNF 21.202 6.616
715 T CAMK/CAMKL/PASK/PASK REKLRELTTIAERLN 11 5.4
428 S CMGC/CDK/CDK2/CDK2 DTLTGEMSPLPTDVR 11.604 6.826
654 Y TK/Csk/CTK VKFGTEQYTAIHRQM 11 10
428 S CMGC/CDK/CDK5/CDK5 DTLTGEMSPLPTDVR 13.79 7.867
79 T AGC/GRK/GRK/GRK FSIARNLTDTLHAAQ 13.389 6.878
628 S CAMK/CAMKL ILINRSGSWADVARQ 11.65 6.355
376 T Other/NEK/NEK11 PGIAGVETAYTRFIT 13 8.933
79 T CAMK/CAMKL FSIARNLTDTLHAAQ 11.184 6.355
636 S Other/AUR/AurC WADVARQSLQRFDST 12.333 6.434
317 S Other/CDC7 GVGNLGASEKSDVFL 12.667 9.583
715 T AGC/GRK REKLRELTTIAERLN 11.112 6.103
8 S CMGC/CDK/CDK5/CDK5 MKIMGTMSPSISLAK 11.309 7.867
602 S Atypical/PIKK/ATR/ATR AEAKVTLSQQLNTLQ 11.023 5.038
428 S CMGC/MAPK/JNK/JNK2 DTLTGEMSPLPTDVR 29.529 6.118
584 S STE/STE20/PAKA/CLA4 SQQGQPVSSETYSFL 11.75 3.825
414 S Other/CDC7/CDC7 DGTIDEESAKQILKD 15.333 9.583
493 S AGC/PKC/PKCh/PRKCH VDKDQLKSFNSLILK 11.3 1.93
674 S CAMK/MAPKAPK/MK5 AITLQEVSEFTDDMR 11.545 6.633
422 T AGC/PDK1/PKH1 AKQILKDTLTGEMSP 11 4.167
472 T STE/STE20/TAO VVLSDLDTMLVALDK 11 6.1
438 T CMGC/MAPK/JNK/JNK2 PTDVRRITPKKLREL 27.471 6.118
8 S CMGC/CDK/CDK2/CDK2 MKIMGTMSPSISLAK 17.53 6.826
222 T STE/STE20/TAO DGWRCSDTLRSLADS 11 6.1
524 S CMGC/CDK/CDK2/CDC28 KSSSTEVSPYHRSNF 12.722 9.411
674 S Other/NEK/NEK11 AITLQEVSEFTDDMR 13 8.933
651 T STE/STE20/MST/MST1 RPVVKFGTEQYTAIH 21.032 2.612
81 T TKL/MLK/MLK/MLK3 IARNLTDTLHAAQKT 11.75 2
79 T CAMK/MAPKAPK FSIARNLTDTLHAAQ 11 6.36
496 S AGC/PKC/PKCh/PRKCH DQLKSFNSLILKTYS 11.4 1.93
524 S CMGC/CDK/CDK2/CDK2 KSSSTEVSPYHRSNF 13.879 6.826
472 T STE/STE20/TAO/TAOK1 VVLSDLDTMLVALDK 11 6.1
396 S CMGC/DYRK/DYRK2 SADSRPDSNEARLHE 13.944 7.053
524 S CMGC/MAPK/JNK/JNK3 KSSSTEVSPYHRSNF 11.875 6.781
90 S Atypical/PIKK/ATR HAAQKTTSQELRSDI 11.362 8.681
8 S Other/PLK MKIMGTMSPSISLAK 15.24 8.093
524 S CMGC/MAPK/JNK/JNK2 KSSSTEVSPYHRSNF 37.088 6.118
396 S AGC/RSK/RSKp90/RPS6KA3 SADSRPDSNEARLHE 11.294 8.112
328 T STE/STE20/MSN/MAP4K4 DVFLVVSTLLHGIEG 11 7
352 T CAMK/MAPKAPK/MK5 NQGLRFITSEPAHVM 11.455 6.633

* Only the results whose Scores are more than 10 are listed here.

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Pfam Domains (Experimental/Computational Results)

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id type start end
Rac1 Pfam 433 729
Pkinase Pfam 147 405

Mutation (Experimental Results)

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POSITION WILD-TYPE AA MUTANT DISEASE/NOTES REFERENCE
Sorry. There is no result for this protein entry.

Pathway (Experimental Results)

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Pathway Accession Number Description
Sorry. There is no result for this protein entry.

Multiple Sequence Alignments (Computational Results)

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Protein Alignment (Computational Results)

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