Comprehensive Information

Detailed Information (Experimental Results)

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Database ID17
UniProt ID A1KWP4 
Name NleA3 protein
Type Type III secretion system effector (T3SE)
Gene Name UN91_01855
Organism Escherichia coli
Gene Ontology Terms -
Function -
Sequence MNIQPIVQSGITTQNNQHNQAKQAPPAQIPQSELPNGCEAGFVVHIPDDIQQHAPECGERTALLSLIQDEGLLSGLDKYLAPHLEEGSAGKKALDMFGLFNVTQMALEIPSSTVPGISGKYGVQLNIVKPDIHPTSGNYFLQIFPLHDEIGINFKDLPGPLKNALSNSNIPTTVSTAASTIASATTSTVTTASKDLIPWFGLTAQVVRNHGVELPIVKTEKGWKLVGETPLTPDGPKANYTEEWVIRPGEVDFKYGTSPLQATLGLEFGAHFKWDLDNSNTKYAVLTNAAANALGAAGGFAVSKIPGVDSMLAPHIGAMVGQAAGHAIQCNTPGLKPDTILWWAGTTLGLADLNKAETGEARFTDYPRIWWHAREGAIFPNKEDIARATGADIRAMEEGVPVDHRHPHPEDVVIDIESSPHNNPSNYVDTVDIIRETRV
Length 439  amino acids
Reference 26120140
IBS
There is no IBS picture for this protein entry.
Sequence Alignment:

Protein Structure (Experimental Results)

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PDB Accession Method Resolution Chain Structure Review
Sorry. There is no result for this protein entry.

Disorder Prediction (Computational Results)

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Start End Sequence
394 439 RAMEEGVPVDHRHPHPEDVVIDIESSPHNNPSNYVDTVDIIRETRV
84 91 LEEGSAGK
161 190 LKNALSNSNIPTTVSTAASTIASATTSTVT
232 237 TPDGPK
1 40 MNIQPIVQSGITTQNNQHNQAKQAPPAQIPQSELPNGCEA
355 358 KAET

Disorder Picture (Computational Results)

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Kinase-specific Phosphorylation Sites (Computational Results)

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Position Code Kinase Peptide Score Cutoff
229 T CMGC/MAPK/ERK/Erk1 GWKLVGETPLTPDGP 11.965 10.326
419 S CMGC/CDK/CDK2/CDC28 VVIDIESSPHNNPSN 17.861 9.411
113 T STE/STE20/MSN/MAP4K4 ALEIPSSTVPGISGK 12 7
183 S Other/CDC7 TAASTIASATTSTVT 15.333 9.583
13 T CK1/VRK/VRK2 IVQSGITTQNNQHNQ 19.25 4
332 T CMGC/MAPK/ERK/Erk1 GHAIQCNTPGLKPDT 14.764 10.326
229 T CMGC/CDK/CDK5/PHO85 GWKLVGETPLTPDGP 11.222 7.061
389 T STE/STE20/PAKA/PAK1 KEDIARATGADIRAM 11.711 6.979
12 T Other/TTK/TTK PIVQSGITTQNNQHN 56.182 47.968
332 T CMGC/CDK/CDK5/PHO85 GHAIQCNTPGLKPDT 12.778 7.061
419 S CMGC/MAPK/ERK/Erk1 VVIDIESSPHNNPSN 18.597 10.326
332 T CMGC/MAPK/JNK/JNK2 GHAIQCNTPGLKPDT 26.941 6.118
13 T CK1 IVQSGITTQNNQHNQ 16.417 5.313
166 S AGC/RSK/RSKp90/RPS6KA3 GPLKNALSNSNIPTT 12.059 8.112
258 S CMGC/MAPK/JNK/JNK2 VDFKYGTSPLQATLG 22.412 6.118
113 T STE/STE20/MSN/MINK1 ALEIPSSTVPGISGK 12 7
176 T Other/PLK NIPTTVSTAASTIAS 12.344 8.093
419 S CMGC/CDK/CDK5/PHO85 VVIDIESSPHNNPSN 11.944 7.061
232 T CMGC/DYRK/DYRK2 LVGETPLTPDGPKAN 13.889 7.053
180 T STE/STE20/MSN/MINK1 TVSTAASTIASATTS 13 7
418 S Other/CDC7 DVVIDIESSPHNNPS 11.667 9.583
112 S CAMK/MAPKAPK/MNK/MNK1 MALEIPSSTVPGISG 11 8.333
258 S Atypical/PIKK/FRAP VDFKYGTSPLQATLG 11.333 8.145
258 S CMGC/CDK/CDK5/CDK5 VDFKYGTSPLQATLG 13.938 7.867
258 S CMGC/CDK/CDK5/PHO85 VDFKYGTSPLQATLG 12.111 7.061
437 T Other/PEK TVDIIRETRV***** 11.455 2.678
187 S TKL/STKR/STKR1 TIASATTSTVTTASK 11.125 6.85
168 S TKL/MLK LKNALSNSNIPTTVS 16.16 7.138
186 T AGC/GRK/GRK/GRK STIASATTSTVTTAS 12.556 6.878
79 Y TK/Src/SrcB/HCK LLSGLDKYLAPHLEE 11.733 6.378
339 T STE/STE20/TAO/TAOK1 TPGLKPDTILWWAGT 11 6.1
346 T Atypical/PDHK/PDHK/PDK1 TILWWAGTTLGLADL 23.027 2.714
430 T AGC/GRK/BARK NPSNYVDTVDIIRET 13.233 3.806
437 T AGC/PKC/PKCa/PRKCA TVDIIRETRV***** 12.995 5.842
389 T TKL/LISK/LIMK KEDIARATGADIRAM 11 6
437 T AGC/PKC/PKCa/PRKCB TVDIIRETRV***** 13.259 8.434
113 T STE/STE20/PAKA/PAK3 ALEIPSSTVPGISGK 13 5.9
185 T STE/STE20/MST/MST1 ASTIASATTSTVTTA 45.484 2.612
232 T CMGC/CDK/CDK2/CDK2 LVGETPLTPDGPKAN 11.067 6.826
232 T CMGC/MAPK/ERK/Erk2 LVGETPLTPDGPKAN 19.429 4.61
180 T STE/STE20/MSN/MAP4K4 TVSTAASTIASATTS 13 7
419 S CMGC/CDK/CDK5 VVIDIESSPHNNPSN 12.394 6.616
258 S CMGC/CDK/CDK5 VDFKYGTSPLQATLG 12.697 6.616
283 Y TK/Csk/CSK LDNSNTKYAVLTNAA 12 9.741
332 T CMGC/CDK/CDK5/CDK5 GHAIQCNTPGLKPDT 14.222 7.867
437 T AGC/GRK/GRK/GRK TVDIIRETRV***** 12.278 6.878
425 S CAMK/MAPKAPK/MNK/MNK2 SSPHNNPSNYVDTVD 13.286 6.869
232 T Other/TTK/TTK LVGETPLTPDGPKAN 50.182 47.968
232 T CMGC/MAPK/JNK/JNK2 LVGETPLTPDGPKAN 31.559 6.118
419 S CMGC/DYRK/DYRK2 VVIDIESSPHNNPSN 11.944 7.053
12 T CK1 PIVQSGITTQNNQHN 14.479 5.313
193 S Other/CDC7 TSTVTTASKDLIPWF 11 9.583
179 S CAMK/MAPKAPK/MNK/MNK1 TTVSTAASTIASATT 11.5 8.333
185 T TKL/STKR/STKR1 ASTIASATTSTVTTA 13.625 6.85
437 T AGC/DMPK/ROCK TVDIIRETRV***** 18.226 6.326
332 T CK1/TTBK/TTBK1 GHAIQCNTPGLKPDT 13.625 5.133
172 T Other/TTK/TTK LSNSNIPTTVSTAAS 49.636 47.968
193 S Other/CDC7/CDC7 TSTVTTASKDLIPWF 11 9.583
188 T STE/STE20/MSN/TNIK IASATTSTVTTASKD 12 7
358 T Other/NEK/NEK11 ADLNKAETGEARFTD 14.333 8.933
168 S AGC/GRK/GRK/GRK LKNALSNSNIPTTVS 12.167 6.878
188 T STE/STE20/MSN/MINK1 IASATTSTVTTASKD 12 7
418 S Other/CDC7/CDC7 DVVIDIESSPHNNPS 11.667 9.583
366 Y TK/Csk/CSK GEARFTDYPRIWWHA 11.148 9.741
183 S Other/CDC7/CDC7 TAASTIASATTSTVT 15.333 9.583
437 T AGC/GRK/BARK TVDIIRETRV***** 15.488 3.806
279 S AGC/GRK/GRK/GRK FKWDLDNSNTKYAVL 11 6.878
364 T STE/STE7/MEK3/MAP2K4 ETGEARFTDYPRIWW 12.4 0.017
419 S CMGC/MAPK/JNK/JNK2 VVIDIESSPHNNPSN 25.324 6.118
430 T AGC/GRK/BARK/BARK1 NPSNYVDTVDIIRET 22.69 3.384
168 S CAMK/MAPKAPK/MNK/MNK2 LKNALSNSNIPTTVS 16.286 6.869
185 T CK1/CK1/CK1-D/CSNK1D ASTIASATTSTVTTA 11.55 8.142
229 T CK1/TTBK GWKLVGETPLTPDGP 12.5 3.877
258 S CMGC/MAPK/ERK/Erk1 VDFKYGTSPLQATLG 16.549 10.326
229 T Atypical/PIKK/FRAP GWKLVGETPLTPDGP 15.139 8.145
232 T Atypical/PIKK/FRAP LVGETPLTPDGPKAN 15.361 8.145
232 T CMGC/CDK/CDK5 LVGETPLTPDGPKAN 14.253 6.616
229 T CMGC/MAPK/JNK/JNK2 GWKLVGETPLTPDGP 30.029 6.118
12 T CK1/VRK/VRK2 PIVQSGITTQNNQHN 18.25 4
232 T CMGC/MAPK/ERK/Erk1 LVGETPLTPDGPKAN 28.556 10.326
232 T CMGC/CDK/CDK2/CDC28 LVGETPLTPDGPKAN 12.194 9.411
113 T STE/STE20/MSN/TNIK ALEIPSSTVPGISGK 12 7
9 S CK1/VRK/VRK2 NIQPIVQSGITTQNN 14 4
366 Y TK/Trk/TRKA GEARFTDYPRIWWHA 12.6 11.95
188 T STE/STE20/MSN/MAP4K4 IASATTSTVTTASKD 12 7
183 S CAMK/RAD53/DUN1 TAASTIASATTSTVT 11 6.017
232 T CMGC/CDK/CDK5/CDK5 LVGETPLTPDGPKAN 12.864 7.867
339 T STE/STE20/TAO TPGLKPDTILWWAGT 11 6.1
180 T STE/STE20/MSN/TNIK TVSTAASTIASATTS 13 7
191 T Other/TTK/TTK ATTSTVTTASKDLIP 57.182 47.968
229 T CMGC/CDK/CDK5/CDK5 GWKLVGETPLTPDGP 18.593 7.867
425 S Other/PLK SSPHNNPSNYVDTVD 18.974 8.093
279 S CAMK/MAPKAPK/MNK/MNK2 FKWDLDNSNTKYAVL 13.286 6.869
258 S CMGC/MAPK/ERK/FUS3 VDFKYGTSPLQATLG 11.667 3.833
419 S CMGC/MAPK/ERK/FUS3 VVIDIESSPHNNPSN 11.333 3.833
332 T CMGC/MAPK/JNK/JNK3 GHAIQCNTPGLKPDT 12.062 6.781
389 T Other/AUR/AurB KEDIARATGADIRAM 11.241 7.092
180 T CK1/CK1/CK1-D/CK1e TVSTAASTIASATTS 11.647 4.55
419 S CMGC/CDK/CDK2/CDK2 VVIDIESSPHNNPSN 18.617 6.826
188 T Other/TTK/TTK IASATTSTVTTASKD 51.182 47.968
437 T AGC/GRK/BARK/BARK1 TVDIIRETRV***** 21.976 3.384
389 T TKL/LISK/LIMK/LIMK1 KEDIARATGADIRAM 11 6
172 T Atypical/PDHK/PDHK/PDK1 LSNSNIPTTVSTAAS 12.486 2.714
229 T CMGC/CDK/CDC2/CDK1 GWKLVGETPLTPDGP 12.344 4.168
232 T CMGC/MAPK LVGETPLTPDGPKAN 13.303 4.55
176 T Other/TTK/TTK NIPTTVSTAASTIAS 48 47.968
389 T AGC/DMPK/ROCK KEDIARATGADIRAM 18.032 6.326
172 T AGC/GRK/GRK/GRK LSNSNIPTTVSTAAS 12.389 6.878

* Only the results whose Scores are more than 10 are listed here.

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Pfam Domains (Experimental/Computational Results)

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id type start end
Sorry. There is no result for this protein entry.

Mutation (Experimental Results)

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POSITION WILD-TYPE AA MUTANT DISEASE/NOTES REFERENCE
Sorry. There is no result for this protein entry.

Pathway (Experimental Results)

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Pathway Accession Number Description
Sorry. There is no result for this protein entry.

Multiple Sequence Alignments (Computational Results)

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  • Sorry. There is no multiple sequence alignment information for this entry.

Protein Alignment (Computational Results)

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  • Sorry. There is no ortholog information for this entry.
  • Sorry. There is no alignment file for this entry.