Comprehensive Information
Detailed Information (Experimental Results)
| Database ID | 18 |
| UniProt ID |
A1KWP5
|
| Name |
NleA4 protein
|
| Type |
Type III secretion system effector (T3SE)
|
| Gene Name |
nleA4
|
| Organism |
Escherichia coli
|
| Gene Ontology Terms |
-
|
| Function |
-
|
| Sequence |
MFGLFNVTQMALEITSTVPGISGKYGVQLNIVKPDIHPTSGNYFLQIFPLHDEIGINFKDLPGPLKNALSNSNIPTTVSTAASTIASATTSTVTTASKDLIPWFGLTAQVVRNHGVELPIVKTEKGWKLVGETPLTPDGPKANYTEEWVIRPGEVDFKYGTSPLQATLGLEFGAHFKWDLDNSNTKYAVLTNAAANALGAAGGFAVSKIPGVDSMLAPHIGAMVGQVAGHAIQCNTPGLKPDTILWWAGTTLGLADLNKAETGEARFTDYPRIWWHAREGAIFPNKEDIARATGADIRAMEEGVPVGQSHPRPEDVVINIESYDLPHHNPLNHVDIVDIIRETRV
|
| Length |
345 amino acids
|
| Reference |
24391954
|
| IBS |
|
Protein Structure (Experimental Results)
| PDB Accession |
Method |
Resolution |
Chain |
Structure Review |
| Sorry. There is no result for this protein entry. |
Disorder Prediction (Computational Results)
| Start |
End |
Sequence |
| 1 |
3 |
MFG |
| 259 |
262 |
KAET |
| 342 |
345 |
ETRV |
| 136 |
141 |
TPDGPK |
| 65 |
94 |
LKNALSNSNIPTTVSTAASTIASATTSTVT |
| 302 |
314 |
EGVPVGQSHPRPE |
Disorder Picture (Computational Results)
Kinase-specific Phosphorylation Sites (Computational Results)
| Position |
Code |
Kinase |
Peptide |
Score |
Cutoff |
| 136 |
T |
CMGC/MAPK/ERK/Erk1 |
LVGETPLTPDGPKAN |
28.556 |
10.326 |
| 343 |
T |
AGC/GRK/GRK/GRK |
IVDIIRETRV***** |
12.278 |
6.878 |
| 322 |
S |
AGC/PKC/PKCi |
DVVINIESYDLPHHN |
13.167 |
7.442 |
| 236 |
T |
CMGC/MAPK/JNK/JNK2 |
GHAIQCNTPGLKPDT |
26.941 |
6.118 |
| 92 |
T |
STE/STE20/MSN/MAP4K4 |
IASATTSTVTTASKD |
12 |
7 |
| 293 |
T |
TKL/LISK/LIMK |
KEDIARATGADIRAM |
11 |
6 |
| 136 |
T |
CMGC/DYRK/DYRK2 |
LVGETPLTPDGPKAN |
13.889 |
7.053 |
| 162 |
S |
CMGC/CDK/CDK5 |
VDFKYGTSPLQATLG |
12.697 |
6.616 |
| 187 |
Y |
TK/Csk/CSK |
LDNSNTKYAVLTNAA |
12 |
9.741 |
| 133 |
T |
CMGC/MAPK/JNK/JNK2 |
GWKLVGETPLTPDGP |
30.029 |
6.118 |
| 162 |
S |
CMGC/MAPK/JNK/JNK2 |
VDFKYGTSPLQATLG |
22.412 |
6.118 |
| 162 |
S |
CMGC/CDK/CDK5/CDK5 |
VDFKYGTSPLQATLG |
13.938 |
7.867 |
| 17 |
T |
Other/TTK/TTK |
MALEITSTVPGISGK |
64.545 |
47.968 |
| 84 |
T |
STE/STE20/MSN/TNIK |
TVSTAASTIASATTS |
13 |
7 |
| 84 |
T |
CK1/CK1/CK1-D/CK1e |
TVSTAASTIASATTS |
11.647 |
4.55 |
| 72 |
S |
TKL/MLK |
LKNALSNSNIPTTVS |
16.16 |
7.138 |
| 343 |
T |
AGC/DMPK/ROCK |
IVDIIRETRV***** |
12.903 |
6.326 |
| 84 |
T |
STE/STE20/MSN/MAP4K4 |
TVSTAASTIASATTS |
13 |
7 |
| 72 |
S |
AGC/GRK/GRK/GRK |
LKNALSNSNIPTTVS |
12.167 |
6.878 |
| 76 |
T |
Other/TTK/TTK |
LSNSNIPTTVSTAAS |
49.636 |
47.968 |
| 133 |
T |
Atypical/PIKK/FRAP |
GWKLVGETPLTPDGP |
15.139 |
8.145 |
| 89 |
T |
TKL/STKR/STKR1 |
ASTIASATTSTVTTA |
13.625 |
6.85 |
| 136 |
T |
CMGC/CDK/CDK5/CDK5 |
LVGETPLTPDGPKAN |
12.864 |
7.867 |
| 70 |
S |
AGC/RSK/RSKp90/RPS6KA3 |
GPLKNALSNSNIPTT |
12.059 |
8.112 |
| 92 |
T |
Other/TTK/TTK |
IASATTSTVTTASKD |
51.182 |
47.968 |
| 243 |
T |
STE/STE20/TAO/TAOK1 |
TPGLKPDTILWWAGT |
11 |
6.1 |
| 136 |
T |
Other/TTK/TTK |
LVGETPLTPDGPKAN |
50.182 |
47.968 |
| 133 |
T |
CMGC/CDK/CDK5/CDK5 |
GWKLVGETPLTPDGP |
18.593 |
7.867 |
| 293 |
T |
AGC/DMPK/ROCK |
KEDIARATGADIRAM |
18.823 |
6.326 |
| 15 |
T |
CK1/VRK/VRK2 |
TQMALEITSTVPGIS |
13.5 |
4 |
| 262 |
T |
Other/NEK/NEK11 |
ADLNKAETGEARFTD |
14.333 |
8.933 |
| 17 |
T |
STE/STE20/MSN/MINK1 |
MALEITSTVPGISGK |
12 |
7 |
| 95 |
T |
Other/TTK/TTK |
ATTSTVTTASKDLIP |
57.182 |
47.968 |
| 17 |
T |
STE/STE20/PAKA/PAK3 |
MALEITSTVPGISGK |
13 |
5.9 |
| 97 |
S |
Other/CDC7 |
TSTVTTASKDLIPWF |
11 |
9.583 |
| 343 |
T |
AGC/PKC/PKCa/PRKCB |
IVDIIRETRV***** |
13.259 |
8.434 |
| 17 |
T |
STE/STE20/MSN/TNIK |
MALEITSTVPGISGK |
12 |
7 |
| 136 |
T |
CMGC/CDK/CDK5 |
LVGETPLTPDGPKAN |
14.253 |
6.616 |
| 91 |
S |
TKL/STKR/STKR1 |
TIASATTSTVTTASK |
11.125 |
6.85 |
| 162 |
S |
CMGC/MAPK/ERK/FUS3 |
VDFKYGTSPLQATLG |
11.667 |
3.833 |
| 89 |
T |
STE/STE20/MST/MST1 |
ASTIASATTSTVTTA |
45.484 |
2.612 |
| 183 |
S |
CAMK/MAPKAPK/MNK/MNK2 |
FKWDLDNSNTKYAVL |
13.286 |
6.869 |
| 293 |
T |
Other/PEK |
KEDIARATGADIRAM |
18.636 |
2.678 |
| 87 |
S |
Other/CDC7 |
TAASTIASATTSTVT |
15.333 |
9.583 |
| 343 |
T |
AGC/GRK/BARK |
IVDIIRETRV***** |
15.488 |
3.806 |
| 17 |
T |
STE/STE20/MSN/MAP4K4 |
MALEITSTVPGISGK |
12 |
7 |
| 87 |
S |
Other/CDC7/CDC7 |
TAASTIASATTSTVT |
15.333 |
9.583 |
| 83 |
S |
CAMK/MAPKAPK/MNK/MNK1 |
TTVSTAASTIASATT |
11.5 |
8.333 |
| 92 |
T |
STE/STE20/MSN/MINK1 |
IASATTSTVTTASKD |
12 |
7 |
| 133 |
T |
CMGC/CDK/CDC2/CDK1 |
GWKLVGETPLTPDGP |
12.344 |
4.168 |
| 136 |
T |
CMGC/MAPK/JNK/JNK2 |
LVGETPLTPDGPKAN |
31.559 |
6.118 |
| 8 |
T |
CK1/VRK/VRK2 |
MFGLFNVTQMALEIT |
20.25 |
4 |
| 270 |
Y |
TK/Csk/CSK |
GEARFTDYPRIWWHA |
11.148 |
9.741 |
| 72 |
S |
CAMK/MAPKAPK/MNK/MNK2 |
LKNALSNSNIPTTVS |
16.286 |
6.869 |
| 236 |
T |
CMGC/CDK/CDK2/CDK2 |
GHAIQCNTPGLKPDT |
11.315 |
6.826 |
| 80 |
T |
Other/PLK |
NIPTTVSTAASTIAS |
12.344 |
8.093 |
| 162 |
S |
CMGC/MAPK/ERK/Erk1 |
VDFKYGTSPLQATLG |
16.549 |
10.326 |
| 80 |
T |
Other/TTK/TTK |
NIPTTVSTAASTIAS |
48 |
47.968 |
| 162 |
S |
Atypical/PIKK/FRAP |
VDFKYGTSPLQATLG |
11.333 |
8.145 |
| 243 |
T |
STE/STE20/TAO |
TPGLKPDTILWWAGT |
11 |
6.1 |
| 90 |
T |
AGC/GRK/GRK/GRK |
STIASATTSTVTTAS |
12.556 |
6.878 |
| 87 |
S |
CAMK/RAD53/DUN1 |
TAASTIASATTSTVT |
11 |
6.017 |
| 133 |
T |
CMGC/CDK/CDK5/PHO85 |
GWKLVGETPLTPDGP |
11.222 |
7.061 |
| 183 |
S |
AGC/GRK/GRK/GRK |
FKWDLDNSNTKYAVL |
11 |
6.878 |
| 236 |
T |
CMGC/MAPK/ERK/Erk1 |
GHAIQCNTPGLKPDT |
14.764 |
10.326 |
| 268 |
T |
STE/STE7/MEK3/MAP2K4 |
ETGEARFTDYPRIWW |
12.4 |
0.017 |
| 343 |
T |
AGC/GRK/BARK/BARK1 |
IVDIIRETRV***** |
21.976 |
3.384 |
| 136 |
T |
CMGC/CDK/CDK2/CDK2 |
LVGETPLTPDGPKAN |
11.067 |
6.826 |
| 133 |
T |
CK1/TTBK |
GWKLVGETPLTPDGP |
12.5 |
3.877 |
| 17 |
T |
CK1/VRK/VRK2 |
MALEITSTVPGISGK |
11.5 |
4 |
| 270 |
Y |
TK/Trk/TRKA |
GEARFTDYPRIWWHA |
12.6 |
11.95 |
| 76 |
T |
Atypical/PDHK/PDHK/PDK1 |
LSNSNIPTTVSTAAS |
12.486 |
2.714 |
| 136 |
T |
CMGC/MAPK/ERK/Erk2 |
LVGETPLTPDGPKAN |
19.429 |
4.61 |
| 236 |
T |
CMGC/MAPK/JNK/JNK3 |
GHAIQCNTPGLKPDT |
12.062 |
6.781 |
| 236 |
T |
CK1/TTBK/TTBK1 |
GHAIQCNTPGLKPDT |
13.625 |
5.133 |
| 236 |
T |
CMGC/CDK/CDK5/PHO85 |
GHAIQCNTPGLKPDT |
12.778 |
7.061 |
| 250 |
T |
Atypical/PDHK/PDHK/PDK1 |
TILWWAGTTLGLADL |
23.027 |
2.714 |
| 16 |
S |
AGC/DMPK/ROCK |
QMALEITSTVPGISG |
11.371 |
6.326 |
| 293 |
T |
STE/STE20/PAKA/PAK1 |
KEDIARATGADIRAM |
11.711 |
6.979 |
| 343 |
T |
AGC/GRK |
IVDIIRETRV***** |
13.121 |
6.103 |
| 293 |
T |
Other/AUR/AurB |
KEDIARATGADIRAM |
11.241 |
7.092 |
| 162 |
S |
CMGC/CDK/CDK5/PHO85 |
VDFKYGTSPLQATLG |
12.111 |
7.061 |
| 343 |
T |
AGC/PKC/PKCa/PRKCA |
IVDIIRETRV***** |
12.995 |
5.842 |
| 89 |
T |
CK1/CK1/CK1-D/CSNK1D |
ASTIASATTSTVTTA |
11.55 |
8.142 |
| 136 |
T |
CMGC/CDK/CDK2/CDC28 |
LVGETPLTPDGPKAN |
12.194 |
9.411 |
| 84 |
T |
STE/STE20/MSN/MINK1 |
TVSTAASTIASATTS |
13 |
7 |
| 293 |
T |
TKL/LISK/LIMK/LIMK1 |
KEDIARATGADIRAM |
11 |
6 |
| 16 |
S |
CK1/VRK/VRK2 |
QMALEITSTVPGISG |
13.25 |
4 |
| 76 |
T |
AGC/GRK/GRK/GRK |
LSNSNIPTTVSTAAS |
12.389 |
6.878 |
| 92 |
T |
STE/STE20/MSN/TNIK |
IASATTSTVTTASKD |
12 |
7 |
| 136 |
T |
Atypical/PIKK/FRAP |
LVGETPLTPDGPKAN |
15.361 |
8.145 |
| 133 |
T |
CMGC/MAPK/ERK/Erk1 |
GWKLVGETPLTPDGP |
11.965 |
10.326 |
| 97 |
S |
Other/CDC7/CDC7 |
TSTVTTASKDLIPWF |
11 |
9.583 |
| 309 |
S |
Atypical/PIKK/FRAP |
EGVPVGQSHPRPEDV |
11.472 |
8.145 |
| 236 |
T |
CMGC/CDK/CDK5/CDK5 |
GHAIQCNTPGLKPDT |
14.222 |
7.867 |
| 136 |
T |
CMGC/MAPK |
LVGETPLTPDGPKAN |
13.303 |
4.55 |
* Only the results whose Scores are more than 10 are listed here.
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Pfam Domains (Experimental/Computational Results)
| id |
type |
start |
end |
| Sorry. There is no result for this protein entry. |
Mutation (Experimental Results)
| POSITION |
WILD-TYPE AA |
MUTANT |
DISEASE/NOTES |
REFERENCE |
| Sorry. There is no result for this protein entry. |
Pathway (Experimental Results)
| Pathway Accession Number |
Description |
| Sorry. There is no result for this protein entry. |
Multiple Sequence Alignments (Computational Results)
- Sorry. There is no multiple sequence alignment information for this entry.
Protein Alignment (Computational Results)
- Sorry. There is no ortholog information for this entry.
- Sorry. There is no alignment file for this entry.
