Comprehensive Information
Detailed Information (Experimental Results)
| Database ID | 21 |
| UniProt ID |
A1KWP8
|
| Name |
NleA6-2 protein
|
| Type |
Type III secretion system effector (T3SE)
|
| Gene Name |
nleA6-2
|
| Organism |
Escherichia coli
|
| Gene Ontology Terms |
-
|
| Function |
-
|
| Sequence |
MNIQPIVQSGITTQNNQHNQAEQAPPAQIPQSVLPNGCEAGFVVHIPDDIQQHAPECGERTALLSLIQDEGLLSGLDKYLAPHLEEGSAGKKALDMFGLFNVTQMALEIRSTVPGISGKYGVQMNIVKPDIHPTSGNYFLQIFPLHDEIGFNFKDLPGPLKNALSNSNISTTAVSTIASAATSAATSAATSAASTAVSAITSAATSATTSTVTTEPKDLIPWFGLTAQVVRNHGVELPIVKTENGWKLVGETPLTPDGPKANYTEEWVIRPGEADFKYGTSPLQATLGLEFGAHFKWDLDNPNTKYAVLTNAAANALGAAGGFAVSQIPGVDSMLAPHIGAMVGQAAGHAIQCNTPGLKPDTILWWAGTTLGLADLNKAEFGEARFTDYPRIWWHAREGAIFPNKEDIARATGADIRAMEEGVPVDHRHPHPEDVVIDIESSPHNNPSNYVDTVDIIRETRV
|
| Length |
462 amino acids
|
| Reference |
26120140
|
| IBS |
|
Protein Structure (Experimental Results)
| PDB Accession |
Method |
Resolution |
Chain |
Structure Review |
| Sorry. There is no result for this protein entry. |
Disorder Prediction (Computational Results)
| Start |
End |
Sequence |
| 160 |
214 |
LKNALSNSNISTTAVSTIASAATSAATSAATSAASTAVSAITSAATSATTSTVTT |
| 255 |
260 |
TPDGPK |
| 1 |
36 |
MNIQPIVQSGITTQNNQHNQAEQAPPAQIPQSVLPN |
| 417 |
462 |
RAMEEGVPVDHRHPHPEDVVIDIESSPHNNPSNYVDTVDIIRETRV |
| 83 |
92 |
HLEEGSAGKK |
| 38 |
38 |
C |
Disorder Picture (Computational Results)
Kinase-specific Phosphorylation Sites (Computational Results)
| Position |
Code |
Kinase |
Peptide |
Score |
Cutoff |
| 460 |
T |
AGC/GRK/BARK |
TVDIIRETRV***** |
15.488 |
3.806 |
| 460 |
T |
AGC/GRK/BARK/BARK1 |
TVDIIRETRV***** |
21.976 |
3.384 |
| 190 |
T |
AGC/GRK/GRK/GPRK6 |
SAATSAATSAASTAV |
15.429 |
1.743 |
| 252 |
T |
CMGC/CDK/CDK5/CDK5 |
GWKLVGETPLTPDGP |
17.679 |
7.867 |
| 12 |
T |
Other/TTK/TTK |
PIVQSGITTQNNQHN |
56.182 |
47.968 |
| 442 |
S |
CMGC/CDK/CDK2/CDK2 |
VVIDIESSPHNNPSN |
18.617 |
6.826 |
| 191 |
S |
AGC/RSK/MSK/RPS6KA5 |
AATSAATSAASTAVS |
13.259 |
8.69 |
| 12 |
T |
CK1 |
PIVQSGITTQNNQHN |
12.035 |
5.313 |
| 306 |
Y |
TK/Src/SrcA/FGR |
LDNPNTKYAVLTNAA |
12.4 |
8.74 |
| 412 |
T |
TKL/LISK/LIMK/LIMK1 |
KEDIARATGADIRAM |
11 |
6 |
| 211 |
T |
Atypical/PIKK/FRAP |
ATSATTSTVTTEPKD |
11.861 |
8.145 |
| 355 |
T |
CMGC/MAPK/JNK/JNK3 |
GHAIQCNTPGLKPDT |
12.062 |
6.781 |
| 208 |
T |
CK1/CK1/CK1-D/CSNK1D |
TSAATSATTSTVTTE |
11.2 |
8.142 |
| 211 |
T |
STE/STE20/MSN/TNIK |
ATSATTSTVTTEPKD |
12 |
7 |
| 255 |
T |
CMGC/CDK/CDK2/CDK2 |
LVGETPLTPDGPKAN |
13.329 |
6.826 |
| 412 |
T |
TKL/LISK/LIMK |
KEDIARATGADIRAM |
11 |
6 |
| 252 |
T |
CMGC/MAPK/ERK/Erk1 |
GWKLVGETPLTPDGP |
11.965 |
10.326 |
| 255 |
T |
Atypical/PIKK/FRAP |
LVGETPLTPDGPKAN |
15.361 |
8.145 |
| 12 |
T |
CK1/VRK/VRK2 |
PIVQSGITTQNNQHN |
18.25 |
4 |
| 355 |
T |
CMGC/CDK/CDK5/PHO85 |
GHAIQCNTPGLKPDT |
12.778 |
7.061 |
| 255 |
T |
CMGC/CDK/CDK2/CDC28 |
LVGETPLTPDGPKAN |
12.194 |
9.411 |
| 281 |
S |
CMGC/MAPK/ERK/Erk1 |
ADFKYGTSPLQATLG |
16.549 |
10.326 |
| 460 |
T |
AGC/GRK/GRK/GRK |
TVDIIRETRV***** |
12.278 |
6.878 |
| 281 |
S |
Atypical/PIKK/FRAP |
ADFKYGTSPLQATLG |
11.667 |
8.145 |
| 176 |
T |
STE/STE20/MSN/MAP4K4 |
ISTTAVSTIASAATS |
13 |
7 |
| 441 |
S |
Other/CDC7 |
DVVIDIESSPHNNPS |
11.667 |
9.583 |
| 183 |
S |
TKL/MLK |
TIASAATSAATSAAT |
12.44 |
7.138 |
| 387 |
T |
STE/STE7/MEK3/MAP2K4 |
EFGEARFTDYPRIWW |
12.4 |
0.017 |
| 255 |
T |
CMGC/CDK/CDK5 |
LVGETPLTPDGPKAN |
14.253 |
6.616 |
| 198 |
S |
CAMK/CAMKL/PASK/PASK |
SAASTAVSAITSAAT |
11.667 |
5.4 |
| 211 |
T |
Other/TTK/TTK |
ATSATTSTVTTEPKD |
51.182 |
47.968 |
| 442 |
S |
CMGC/CDK/CDK2/CDC28 |
VVIDIESSPHNNPSN |
17.861 |
9.411 |
| 448 |
S |
CAMK/MAPKAPK/MNK/MNK2 |
SSPHNNPSNYVDTVD |
13.286 |
6.869 |
| 171 |
T |
Other/TTK/TTK |
LSNSNISTTAVSTIA |
55.545 |
47.968 |
| 453 |
T |
AGC/GRK/BARK/BARK1 |
NPSNYVDTVDIIRET |
22.69 |
3.384 |
| 369 |
T |
Atypical/PDHK/PDHK/PDK1 |
TILWWAGTTLGLADL |
25.865 |
2.714 |
| 112 |
T |
STE/STE20/MSN/MINK1 |
MALEIRSTVPGISGK |
12 |
7 |
| 281 |
S |
CMGC/MAPK/ERK/FUS3 |
ADFKYGTSPLQATLG |
11.667 |
3.833 |
| 111 |
S |
AGC/DMPK/ROCK |
QMALEIRSTVPGISG |
12.613 |
6.326 |
| 9 |
S |
CK1/VRK/VRK2 |
NIQPIVQSGITTQNN |
14 |
4 |
| 165 |
S |
AGC/RSK/RSKp90/RPS6KA3 |
GPLKNALSNSNISTT |
12.059 |
8.112 |
| 182 |
T |
CK1/CK1/CK1-D/CK1e |
STIASAATSAATSAA |
14 |
4.55 |
| 252 |
T |
CMGC/MAPK/JNK/JNK2 |
GWKLVGETPLTPDGP |
30.029 |
6.118 |
| 170 |
S |
STE/STE20/PAKA/PAK3 |
ALSNSNISTTAVSTI |
12.533 |
5.9 |
| 179 |
S |
AGC/GRK/BARK/BARK1 |
TAVSTIASAATSAAT |
12.024 |
3.384 |
| 176 |
T |
CAMK/RAD53/CHK2 |
ISTTAVSTIASAATS |
12.068 |
4.788 |
| 255 |
T |
CMGC/MAPK/JNK/JNK2 |
LVGETPLTPDGPKAN |
31.559 |
6.118 |
| 412 |
T |
Other/AUR/AurB |
KEDIARATGADIRAM |
11.241 |
7.092 |
| 167 |
S |
TKL/STKR/STKR1 |
LKNALSNSNISTTAV |
11.25 |
6.85 |
| 255 |
T |
CMGC/DYRK/DYRK2 |
LVGETPLTPDGPKAN |
13.889 |
7.053 |
| 460 |
T |
AGC/DMPK/ROCK |
TVDIIRETRV***** |
18.226 |
6.326 |
| 214 |
T |
Atypical/PIKK/FRAP |
ATTSTVTTEPKDLIP |
12 |
8.145 |
| 170 |
S |
AGC/GRK/GRK/GRK |
ALSNSNISTTAVSTI |
13.833 |
6.878 |
| 194 |
S |
CAMK/MAPKAPK/MNK/MNK1 |
SAATSAASTAVSAIT |
11.5 |
8.333 |
| 209 |
T |
STE/STE20/MST/MST1 |
SAATSATTSTVTTEP |
16.968 |
2.612 |
| 355 |
T |
CK1/TTBK/TTBK1 |
GHAIQCNTPGLKPDT |
13.625 |
5.133 |
| 326 |
S |
Atypical/PIKK/ATR |
AAGGFAVSQIPGVDS |
11.362 |
8.681 |
| 165 |
S |
CAMK/MAPKAPK/MK5 |
GPLKNALSNSNISTT |
16.818 |
6.633 |
| 205 |
T |
CK1/CK1/CK1-D/CSNK1D |
SAITSAATSATTSTV |
17.4 |
8.142 |
| 442 |
S |
CMGC/CDK/CDK5 |
VVIDIESSPHNNPSN |
12.394 |
6.616 |
| 355 |
T |
CMGC/CDK/CDK5/CDK5 |
GHAIQCNTPGLKPDT |
14.222 |
7.867 |
| 255 |
T |
CMGC/MAPK/ERK/Erk1 |
LVGETPLTPDGPKAN |
28.556 |
10.326 |
| 112 |
T |
Other/TTK/TTK |
MALEIRSTVPGISGK |
64.545 |
47.968 |
| 190 |
T |
CK1/CK1/CK1-D/CK1e |
SAATSAATSAASTAV |
17.176 |
4.55 |
| 175 |
S |
TKL/MLK |
NISTTAVSTIASAAT |
11.72 |
7.138 |
| 112 |
T |
STE/STE20/MSN/MAP4K4 |
MALEIRSTVPGISGK |
12 |
7 |
| 389 |
Y |
TK/Csk/CSK |
GEARFTDYPRIWWHA |
11.148 |
9.741 |
| 112 |
T |
STE/STE20/MSN/TNIK |
MALEIRSTVPGISGK |
12 |
7 |
| 176 |
T |
STE/STE20/MSN/MINK1 |
ISTTAVSTIASAATS |
13 |
7 |
| 442 |
S |
CMGC/MAPK/JNK/JNK2 |
VVIDIESSPHNNPSN |
25.324 |
6.118 |
| 441 |
S |
Other/CDC7/CDC7 |
DVVIDIESSPHNNPS |
11.667 |
9.583 |
| 281 |
S |
CMGC/MAPK/JNK/JNK2 |
ADFKYGTSPLQATLG |
22.412 |
6.118 |
| 306 |
Y |
TK/Csk/CSK |
LDNPNTKYAVLTNAA |
12.778 |
9.741 |
| 183 |
S |
AGC/RSK/MSK/RPS6KA5 |
TIASAATSAATSAAT |
13.407 |
8.69 |
| 252 |
T |
CK1/TTBK |
GWKLVGETPLTPDGP |
12.5 |
3.877 |
| 201 |
T |
TKL/MLK |
STAVSAITSAATSAT |
11.64 |
7.138 |
| 255 |
T |
CMGC/MAPK/ERK/Erk2 |
LVGETPLTPDGPKAN |
19.429 |
4.61 |
| 167 |
S |
AGC/GRK/GRK/GRK |
LKNALSNSNISTTAV |
11.444 |
6.878 |
| 460 |
T |
AGC/PKC/PKCa/PRKCB |
TVDIIRETRV***** |
13.259 |
8.434 |
| 13 |
T |
CK1 |
IVQSGITTQNNQHNQ |
13.812 |
5.313 |
| 211 |
T |
STE/STE20/MSN/MAP4K4 |
ATSATTSTVTTEPKD |
12 |
7 |
| 214 |
T |
Other/TTK/TTK |
ATTSTVTTEPKDLIP |
50.273 |
47.968 |
| 186 |
T |
CK1/CK1/CK1-D/CK1e |
SAATSAATSAATSAA |
13.294 |
4.55 |
| 362 |
T |
STE/STE20/TAO/TAOK1 |
TPGLKPDTILWWAGT |
11 |
6.1 |
| 255 |
T |
CMGC/MAPK |
LVGETPLTPDGPKAN |
13.303 |
4.55 |
| 167 |
S |
CAMK/MAPKAPK/MNK/MNK2 |
LKNALSNSNISTTAV |
16.286 |
6.869 |
| 170 |
S |
STE/STE20/MST/MST1 |
ALSNSNISTTAVSTI |
16 |
2.612 |
| 442 |
S |
CMGC/MAPK/ERK/FUS3 |
VVIDIESSPHNNPSN |
11.333 |
3.833 |
| 252 |
T |
Atypical/PIKK/FRAP |
GWKLVGETPLTPDGP |
15.694 |
8.145 |
| 448 |
S |
Other/PLK |
SSPHNNPSNYVDTVD |
18.974 |
8.093 |
| 179 |
S |
Other/CDC7 |
TAVSTIASAATSAAT |
15.333 |
9.583 |
| 13 |
T |
CK1/VRK/VRK2 |
IVQSGITTQNNQHNQ |
19.25 |
4 |
| 355 |
T |
CMGC/MAPK/JNK/JNK2 |
GHAIQCNTPGLKPDT |
26.941 |
6.118 |
| 281 |
S |
CMGC/CDK/CDK5/PHO85 |
ADFKYGTSPLQATLG |
12.111 |
7.061 |
| 205 |
T |
AGC/GRK/GRK/GRK |
SAITSAATSATTSTV |
11.333 |
6.878 |
| 442 |
S |
CMGC/CDK/CDK5/PHO85 |
VVIDIESSPHNNPSN |
11.944 |
7.061 |
| 362 |
T |
STE/STE20/TAO |
TPGLKPDTILWWAGT |
11 |
6.1 |
| 389 |
Y |
TK/Trk/TRKA |
GEARFTDYPRIWWHA |
12.6 |
11.95 |
| 453 |
T |
AGC/GRK/BARK |
NPSNYVDTVDIIRET |
13.233 |
3.806 |
| 205 |
T |
CK1/CK1/CK1-D/CK1e |
SAITSAATSATTSTV |
14 |
4.55 |
| 187 |
S |
AGC/GRK/GRK/GPRK6 |
AATSAATSAATSAAS |
11.429 |
1.743 |
| 460 |
T |
Other/PEK |
TVDIIRETRV***** |
11.455 |
2.678 |
| 79 |
Y |
TK/Src/SrcB/HCK |
LLSGLDKYLAPHLEE |
11.733 |
6.378 |
| 255 |
T |
Other/TTK/TTK |
LVGETPLTPDGPKAN |
50.182 |
47.968 |
| 209 |
T |
TKL/STKR/STKR1 |
SAATSATTSTVTTEP |
11.125 |
6.85 |
| 205 |
T |
TKL/STKR/STKR1 |
SAITSAATSATTSTV |
12.125 |
6.85 |
| 355 |
T |
CMGC/MAPK/ERK/Erk1 |
GHAIQCNTPGLKPDT |
14.764 |
10.326 |
| 112 |
T |
STE/STE20/PAKA/PAK3 |
MALEIRSTVPGISGK |
13.267 |
5.9 |
| 412 |
T |
AGC/DMPK/ROCK |
KEDIARATGADIRAM |
18.032 |
6.326 |
| 179 |
S |
CAMK/RAD53/DUN1 |
TAVSTIASAATSAAT |
11 |
6.017 |
| 187 |
S |
AGC/RSK/MSK/RPS6KA5 |
AATSAATSAATSAAS |
12.148 |
8.69 |
| 255 |
T |
CMGC/CDK/CDK5/CDK5 |
LVGETPLTPDGPKAN |
12.864 |
7.867 |
| 194 |
S |
CAMK/CAMKL/PASK/PASK |
SAATSAASTAVSAIT |
11 |
5.4 |
| 209 |
T |
AGC/GRK/GRK/GRK |
SAATSATTSTVTTEP |
13.833 |
6.878 |
| 460 |
T |
AGC/PKC/PKCa/PRKCA |
TVDIIRETRV***** |
12.995 |
5.842 |
| 171 |
T |
STE/STE20/PAKA/PAK3 |
LSNSNISTTAVSTIA |
14.533 |
5.9 |
| 281 |
S |
CMGC/CDK/CDK5/CDK5 |
ADFKYGTSPLQATLG |
14.346 |
7.867 |
| 442 |
S |
CMGC/DYRK/DYRK2 |
VVIDIESSPHNNPSN |
11.944 |
7.053 |
| 252 |
T |
CMGC/CDK/CDK5/PHO85 |
GWKLVGETPLTPDGP |
11.222 |
7.061 |
| 208 |
T |
TKL/STKR/STKR1 |
TSAATSATTSTVTTE |
13.625 |
6.85 |
| 179 |
S |
Other/CDC7/CDC7 |
TAVSTIASAATSAAT |
15.333 |
9.583 |
| 281 |
S |
CMGC/CDK/CDK5 |
ADFKYGTSPLQATLG |
13.576 |
6.616 |
| 442 |
S |
CMGC/MAPK/ERK/Erk1 |
VVIDIESSPHNNPSN |
18.597 |
10.326 |
| 194 |
S |
AGC/RSK/MSK/RPS6KA5 |
SAATSAASTAVSAIT |
11.815 |
8.69 |
| 182 |
T |
CK1/CK1/CK1-D/CSNK1D |
STIASAATSAATSAA |
12.35 |
8.142 |
| 165 |
S |
CAMK/MAPKAPK/MK5/MAPKAPK5 |
GPLKNALSNSNISTT |
16.818 |
6.633 |
| 211 |
T |
STE/STE20/MSN/MINK1 |
ATSATTSTVTTEPKD |
12 |
7 |
| 195 |
T |
Other/TTK/TTK |
AATSAASTAVSAITS |
55 |
47.968 |
| 252 |
T |
CMGC/CDK/CDC2/CDK1 |
GWKLVGETPLTPDGP |
12.344 |
4.168 |
| 412 |
T |
STE/STE20/PAKA/PAK1 |
KEDIARATGADIRAM |
11.711 |
6.979 |
| 176 |
T |
STE/STE20/MSN/TNIK |
ISTTAVSTIASAATS |
13 |
7 |
| 175 |
S |
AGC/GRK/GRK/GRK |
NISTTAVSTIASAAT |
14.111 |
6.878 |
* Only the results whose Scores are more than 10 are listed here.
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Pfam Domains (Experimental/Computational Results)
| id |
type |
start |
end |
| Sorry. There is no result for this protein entry. |
Mutation (Experimental Results)
| POSITION |
WILD-TYPE AA |
MUTANT |
DISEASE/NOTES |
REFERENCE |
| Sorry. There is no result for this protein entry. |
Pathway (Experimental Results)
| Pathway Accession Number |
Description |
| Sorry. There is no result for this protein entry. |
Multiple Sequence Alignments (Computational Results)
- Sorry. There is no multiple sequence alignment information for this entry.
Protein Alignment (Computational Results)
- Sorry. There is no ortholog information for this entry.
- Sorry. There is no alignment file for this entry.
