Comprehensive Information

Detailed Information (Experimental Results)

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Database ID22
UniProt ID A1KWP9 
Name NleA7 protein
Type Type III secretion system effector (T3SE)
Gene Name nleA7
Organism Escherichia coli
Gene Ontology Terms -
Function -
Sequence MNIQPTIQSGITTQHNQHHHTEQTPPTQIPQSELPLGCQAGFVVNIPDDIQQHAPECGETTVLLSLIKDKGLLSGLDAYIAPHLEEGSAGKKALDTFGLFNVTQMALEIPSSTVPGISGKYGVQMNIVKPDIHPTTGNYVLQLFPAHDEIGINYRDLQGPLKNVLSSDAVPWFGLTAQVVRNHGVELPIVKTENGWKLVGETPLTPDGPKANYTEEWVIRPAEADLKYGTSPFQATLGLEFGAHFKWDLDNSRTKYAILTNAAANAVGAAGGFAVSRLPGVDPMLAPHIGSMAGQALGHAVQCYTPGLKPDTILWWAGTTLGLADLNKAEFGVARFTDYPRIWWHAREGAIFPNKEDIARATGADIRAMEEGIPVGQRHPNPEDVVIDIESNDSPHHNPSNYVDTFDIIRETRV
Length 414  amino acids
Reference 26120140
IBS
There is no IBS picture for this protein entry.
Sequence Alignment:

Protein Structure (Experimental Results)

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PDB Accession Method Resolution Chain Structure Review
Sorry. There is no result for this protein entry.

Disorder Prediction (Computational Results)

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Start End Sequence
1 38 MNIQPTIQSGITTQHNQHHHTEQTPPTQIPQSELPLGC
369 414 MEEGIPVGQRHPNPEDVVIDIESNDSPHHNPSNYVDTFDIIRETRV
117 117 I
86 92 EGSAGKK
205 210 TPDGPK

Disorder Picture (Computational Results)

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Kinase-specific Phosphorylation Sites (Computational Results)

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Position Code Kinase Peptide Score Cutoff
362 T TKL/LISK/LIMK KEDIARATGADIRAM 11 6
231 S CMGC/MAPK/JNK/JNK2 ADLKYGTSPFQATLG 21.412 6.118
291 S Atypical/PDHK/PDHK MLAPHIGSMAGQALG 11.025 2.805
400 S CAMK/MAPKAPK/MNK/MNK2 DSPHHNPSNYVDTFD 13.286 6.869
405 T STE/STE20/TAO/TAOK1 NPSNYVDTFDIIRET 17 6.1
391 S Other/NEK/NEK11 DVVIDIESNDSPHHN 11 8.933
24 T CMGC/CDK/CDK2/CDC28 QHHHTEQTPPTQIPQ 13.611 9.411
405 T STE/STE20/YSK NPSNYVDTFDIIRET 12 6.05
362 T AGC/DMPK/ROCK KEDIARATGADIRAM 19.903 6.326
400 S Other/PLK DSPHHNPSNYVDTFD 13.104 8.093
202 T CMGC/CDK/CDK5/PHO85 GWKLVGETPLTPDGP 11.222 7.061
96 T STE/STE20/TAO/TAOK1 AGKKALDTFGLFNVT 17 6.1
305 T CK1/TTBK/TTBK1 GHAVQCYTPGLKPDT 11 5.133
113 T STE/STE20/MSN/TNIK ALEIPSSTVPGISGK 12 7
402 Y TK/Eph/EphA4 PHHNPSNYVDTFDII 13.75 6.6
394 S CMGC/CDK/CDK2/CDC28 IDIESNDSPHHNPSN 14.806 9.411
202 T Atypical/PIKK/FRAP GWKLVGETPLTPDGP 15.694 8.145
96 T STE/STE20/TAO AGKKALDTFGLFNVT 17 6.1
205 T CMGC/MAPK LVGETPLTPDGPKAN 13.303 4.55
13 T CK1/VRK/VRK2 TIQSGITTQHNQHHH 18.5 4
305 T CMGC/CDK/CDK5/CDK5 GHAVQCYTPGLKPDT 14.37 7.867
205 T CMGC/MAPK/ERK/Erk1 LVGETPLTPDGPKAN 28.556 10.326
305 T CMGC/MAPK/JNK/JNK2 GHAVQCYTPGLKPDT 26.294 6.118
412 T AGC/GRK/BARK/BARK1 TFDIIRETRV***** 21.976 3.384
256 Y TK/Csk/CSK LDNSRTKYAILTNAA 11.296 9.741
27 T Atypical/PIKK/FRAP HTEQTPPTQIPQSEL 13.028 8.145
12 T CK1/VRK/VRK2 PTIQSGITTQHNQHH 19.75 4
96 T AGC/PDK1/PKH2 AGKKALDTFGLFNVT 13.333 5.683
254 T Other/Haspin/Haspin WDLDNSRTKYAILTN 15 7
394 S CMGC/MAPK/JNK/JNK2 IDIESNDSPHHNPSN 25.382 6.118
139 Y TK/Src/SrcA/FGR IHPTTGNYVLQLFPA 11.8 8.74
405 T Atypical/PDHK/PDHK NPSNYVDTFDIIRET 15.8 2.805
305 T CMGC/MAPK/JNK/JNK3 GHAVQCYTPGLKPDT 12.062 6.781
202 T CK1/TTBK GWKLVGETPLTPDGP 12.5 3.877
305 T CMGC/CDK/CDK5/PHO85 GHAVQCYTPGLKPDT 12.222 7.061
113 T STE/STE20/PAKA/PAK3 ALEIPSSTVPGISGK 13.267 5.9
205 T CMGC/CDK/CDK2/CDC28 LVGETPLTPDGPKAN 12.194 9.411
362 T TKL/LISK/LIMK/LIMK1 KEDIARATGADIRAM 11 6
339 Y TK/Trk/TRKA GVARFTDYPRIWWHA 12.6 11.95
231 S CMGC/CDK/CDK5/CDK5 ADLKYGTSPFQATLG 20.173 7.867
254 T Other/Haspin WDLDNSRTKYAILTN 15 7
12 T Other/TTK/TTK PTIQSGITTQHNQHH 56.182 47.968
202 T CMGC/MAPK/JNK/JNK2 GWKLVGETPLTPDGP 30.029 6.118
412 T AGC/DMPK/ROCK TFDIIRETRV***** 17.548 6.326
6 T Other/PLK **MNIQPTIQSGITT 13.175 8.093
79 Y TK/PDGFR/KIT LLSGLDAYIAPHLEE 11.625 8.15
24 T CMGC/CDK/CDC2/CDK1 QHHHTEQTPPTQIPQ 14.357 4.168
27 T Other/TTK/TTK HTEQTPPTQIPQSEL 49.273 47.968
205 T CMGC/DYRK/DYRK2 LVGETPLTPDGPKAN 13.889 7.053
230 T STE/STE-Unique/NIK EADLKYGTSPFQATL 11.667 4.283
205 T CMGC/MAPK/JNK/JNK2 LVGETPLTPDGPKAN 31.559 6.118
339 Y TK/Csk/CSK GVARFTDYPRIWWHA 11.704 9.741
24 T CMGC/CDK/CDK5/CDK5 QHHHTEQTPPTQIPQ 12.481 7.867
112 S CAMK/MAPKAPK/MNK/MNK1 MALEIPSSTVPGISG 11 8.333
12 T Other/PLK PTIQSGITTQHNQHH 12.377 8.093
24 T Atypical/PIKK/FRAP QHHHTEQTPPTQIPQ 13.361 8.145
412 T AGC/GRK/BARK TFDIIRETRV***** 15.488 3.806
176 T STE/STE20/MST/MST1 AVPWFGLTAQVVRNH 14.839 2.612
9 S CK1/VRK/VRK2 NIQPTIQSGITTQHN 13.75 4
256 Y TK/Fak/PYK2 LDNSRTKYAILTNAA 11.7 8.11
24 T CMGC/CDK/CDK4/CDK6 QHHHTEQTPPTQIPQ 11 3.967
312 T STE/STE20/TAO/TAOK1 TPGLKPDTILWWAGT 11 6.1
405 T AGC/GRK NPSNYVDTFDIIRET 20 6.103
113 T STE/STE20/MSN/MINK1 ALEIPSSTVPGISGK 12 7
362 T Other/PEK KEDIARATGADIRAM 15.682 2.678
12 T CK1 PTIQSGITTQHNQHH 13.819 5.313
394 S CMGC/CDK/CDK5/CDK5 IDIESNDSPHHNPSN 16.247 7.867
60 T Atypical/PIKK/FRAP HAPECGETTVLLSLI 12.111 8.145
24 T CMGC/MAPK/ERK/Erk1 QHHHTEQTPPTQIPQ 13.312 10.326
205 T Atypical/PIKK/FRAP LVGETPLTPDGPKAN 15.361 8.145
319 T Atypical/PDHK/PDHK/PDK1 TILWWAGTTLGLADL 23.27 2.714
202 T CMGC/MAPK/ERK/Erk1 GWKLVGETPLTPDGP 11.965 10.326
113 T STE/STE20/MSN/MAP4K4 ALEIPSSTVPGISGK 12 7
205 T CMGC/CDK/CDK5/CDK5 LVGETPLTPDGPKAN 12.864 7.867
412 T Other/PEK TFDIIRETRV***** 11.273 2.678
205 T CMGC/CDK/CDK2/CDK2 LVGETPLTPDGPKAN 13.329 6.826
405 T AGC/PDK1/PKH2 NPSNYVDTFDIIRET 13.333 5.683
231 S CMGC/MAPK/ERK/FUS3 ADLKYGTSPFQATLG 11.667 3.833
412 T AGC/PKC/PKCa/PRKCA TFDIIRETRV***** 12.995 5.842
405 T AGC/GRK/BARK NPSNYVDTFDIIRET 12.558 3.806
202 T CMGC/CDK/CDC2/CDK1 GWKLVGETPLTPDGP 12.344 4.168
205 T CMGC/CDK/CDK5 LVGETPLTPDGPKAN 14.253 6.616
394 S CMGC/CDK/CDK2/CDK2 IDIESNDSPHHNPSN 20.262 6.826
205 T CMGC/MAPK/ERK/Erk2 LVGETPLTPDGPKAN 19.429 4.61
79 Y TK/Eph/EphB1 LLSGLDAYIAPHLEE 11.333 7.967
6 T CK1/VRK/VRK2 **MNIQPTIQSGITT 24 4
79 Y TK/Src/SrcB/HCK LLSGLDAYIAPHLEE 13.4 6.378
135 T Other/TTK/TTK VKPDIHPTTGNYVLQ 48.364 47.968
24 T CMGC/MAPK/ERK/Erk2 QHHHTEQTPPTQIPQ 13.181 4.61
231 S CMGC/CDK/CDK5/PHO85 ADLKYGTSPFQATLG 14 7.061
405 T STE/STE20/TAO NPSNYVDTFDIIRET 17 6.1
231 S CMGC/CDK/CDK2/CDC28 ADLKYGTSPFQATLG 11.667 9.411
362 T STE/STE20/PAKA/PAK1 KEDIARATGADIRAM 11.711 6.979
60 T Other/TTK/TTK HAPECGETTVLLSLI 56.455 47.968
213 Y TK/EGFR PDGPKANYTEEWVIR 11.41 6.45
24 T CMGC/MAPK/JNK/JNK2 QHHHTEQTPPTQIPQ 32.206 6.118
13 T CK1 TIQSGITTQHNQHHH 14.646 5.313
412 T AGC/GRK/GRK/GRK TFDIIRETRV***** 12.278 6.878
394 S CMGC/MAPK/JNK/JNK3 IDIESNDSPHHNPSN 11.688 6.781
96 T STE/STE20/YSK AGKKALDTFGLFNVT 12 6.05
405 T AGC/GRK/BARK/BARK1 NPSNYVDTFDIIRET 22.69 3.384
312 T STE/STE20/TAO TPGLKPDTILWWAGT 11 6.1
412 T AGC/PKC/PKCa/PRKCB TFDIIRETRV***** 13.259 8.434
362 T Other/AUR/AurB KEDIARATGADIRAM 11.241 7.092
205 T Other/TTK/TTK LVGETPLTPDGPKAN 50.182 47.968
305 T CMGC/MAPK/ERK/Erk1 GHAVQCYTPGLKPDT 13.903 10.326
394 S CMGC/CDK/CDK5 IDIESNDSPHHNPSN 14.859 6.616
154 Y TK/Trk/TRKA HDEIGINYRDLQGPL 20.4 11.95
394 S CK1/TTBK/TTBK1 IDIESNDSPHHNPSN 13.125 5.133
202 T CMGC/CDK/CDK5/CDK5 GWKLVGETPLTPDGP 17.679 7.867
139 Y TK/PDGFR/PDGFRA IHPTTGNYVLQLFPA 11.2 8.814
231 S CMGC/MAPK/ERK/Erk1 ADLKYGTSPFQATLG 17.514 10.326
231 S CMGC/CDK/CDK5 ADLKYGTSPFQATLG 13.182 6.616

* Only the results whose Scores are more than 10 are listed here.

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Pfam Domains (Experimental/Computational Results)

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id type start end
Sorry. There is no result for this protein entry.

Mutation (Experimental Results)

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POSITION WILD-TYPE AA MUTANT DISEASE/NOTES REFERENCE
Sorry. There is no result for this protein entry.

Pathway (Experimental Results)

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Pathway Accession Number Description
Sorry. There is no result for this protein entry.

Multiple Sequence Alignments (Computational Results)

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  • Sorry. There is no multiple sequence alignment information for this entry.

Protein Alignment (Computational Results)

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  • Sorry. There is no ortholog information for this entry.
  • Sorry. There is no alignment file for this entry.