Comprehensive Information
Detailed Information (Experimental Results)
| Database ID | 23 |
| UniProt ID |
A1KWQ0
|
| Name |
NleA8-1 protein
|
| Type |
Type III secretion system effector (T3SE)
|
| Gene Name |
ERS150876_02855
|
| Organism |
Escherichia coli
|
| Gene Ontology Terms |
-
|
| Function |
-
|
| Sequence |
MNIQPIVTSGITTQNNRHHHAEQTSPTQIPQSELPNGCETGFVVHIPEDMQRHAPECGETTALLSLIKDEGLLSGLDKYLAPHLEEGSAGKKALDMFGLFNVSQMALEIPSTVPGISGKYGVQLNIVKPDIHPTSGNYFLQIFPLHDEIGINFKDLPGPLKNALSNSNIPTTVSTAASTIASATTSTVTTASKDPIPWFGLTAQVVRNHGVELPIVKTENGWKLVGETPLTPDGPKANYTEEWVIRPGEADFKYGASPLQATLGLEFGAHFKWDLDNPNTKYAVLTNAAANALGAVGGFAVSRFTGTDPMLSPHIGAMVGQAAGHAIQYNTPGLKPDTILWWAGTTLGLADLNKAETGEGRFTDYPRIWWHAREGAIFPNKEDIARATGADIRAMEEGIPVGQRHPNPEDVVIDIESNGSPHHNPSNYVDTFDIIQETRV
|
| Length |
440 amino acids
|
| Reference |
26120140
|
| IBS |
|
Protein Structure (Experimental Results)
| PDB Accession |
Method |
Resolution |
Chain |
Structure Review |
| Sorry. There is no result for this protein entry. |
Disorder Prediction (Computational Results)
| Start |
End |
Sequence |
| 353 |
359 |
NKAETGE |
| 1 |
41 |
MNIQPIVTSGITTQNNRHHHAEQTSPTQIPQSELPNGCETG |
| 83 |
91 |
HLEEGSAGK |
| 50 |
57 |
MQRHAPEC |
| 160 |
191 |
LKNALSNSNIPTTVSTAASTIASATTSTVTTA |
| 231 |
236 |
TPDGPK |
| 436 |
440 |
QETRV |
| 395 |
428 |
MEEGIPVGQRHPNPEDVVIDIESNGSPHHNPSNY |
Disorder Picture (Computational Results)
Kinase-specific Phosphorylation Sites (Computational Results)
| Position |
Code |
Kinase |
Peptide |
Score |
Cutoff |
| 179 |
T |
STE/STE20/MSN/MAP4K4 |
TVSTAASTIASATTS |
13 |
7 |
| 431 |
T |
AGC/PDK1/PKH2 |
NPSNYVDTFDIIQET |
13.333 |
5.683 |
| 228 |
T |
CMGC/CDK/CDK5/CDK5 |
GWKLVGETPLTPDGP |
17.679 |
7.867 |
| 186 |
S |
TKL/STKR/STKR1 |
TIASATTSTVTTASK |
11.125 |
6.85 |
| 420 |
S |
CMGC/CDK/CDK2/CDC28 |
IDIESNGSPHHNPSN |
14.806 |
9.411 |
| 13 |
T |
CK1/VRK/VRK2 |
IVTSGITTQNNRHHH |
19.25 |
4 |
| 112 |
T |
STE/STE20/MSN/TNIK |
MALEIPSTVPGISGK |
12 |
7 |
| 420 |
S |
CMGC/CDK/CDK5/CDK5 |
IDIESNGSPHHNPSN |
16.79 |
7.867 |
| 331 |
T |
CMGC/CDK/CDK5 |
GHAIQYNTPGLKPDT |
11.152 |
6.616 |
| 331 |
T |
CK1/TTBK/TTBK1 |
GHAIQYNTPGLKPDT |
13.625 |
5.133 |
| 420 |
S |
CMGC/MAPK/JNK/JNK2 |
IDIESNGSPHHNPSN |
24.853 |
6.118 |
| 112 |
T |
STE/STE20/MSN/MAP4K4 |
MALEIPSTVPGISGK |
12 |
7 |
| 357 |
T |
Other/NEK/NEK11 |
ADLNKAETGEGRFTD |
12.667 |
8.933 |
| 282 |
Y |
TK/Src/SrcA/FGR |
LDNPNTKYAVLTNAA |
12.4 |
8.74 |
| 426 |
S |
Other/PLK |
GSPHHNPSNYVDTFD |
12.253 |
8.093 |
| 228 |
T |
CMGC/MAPK/JNK/JNK2 |
GWKLVGETPLTPDGP |
30.029 |
6.118 |
| 228 |
T |
CK1/TTBK |
GWKLVGETPLTPDGP |
12.5 |
3.877 |
| 420 |
S |
CMGC/CDK/CDK5 |
IDIESNGSPHHNPSN |
15.515 |
6.616 |
| 420 |
S |
CMGC/DYRK/DYRK2 |
IDIESNGSPHHNPSN |
11.611 |
7.053 |
| 25 |
S |
CMGC/MAPK/JNK/JNK3 |
HHHAEQTSPTQIPQS |
11.688 |
6.781 |
| 420 |
S |
CMGC/MAPK/ERK/FUS3 |
IDIESNGSPHHNPSN |
11.667 |
3.833 |
| 187 |
T |
Other/TTK/TTK |
IASATTSTVTTASKD |
51.182 |
47.968 |
| 257 |
S |
CMGC/MAPK/JNK/JNK2 |
ADFKYGASPLQATLG |
22.353 |
6.118 |
| 112 |
T |
STE/STE20/PAKA/PAK3 |
MALEIPSTVPGISGK |
13 |
5.9 |
| 231 |
T |
CMGC/CDK/CDK5/CDK5 |
LVGETPLTPDGPKAN |
12.864 |
7.867 |
| 331 |
T |
CMGC/CDK/CDK5/PHO85 |
GHAIQYNTPGLKPDT |
12.778 |
7.061 |
| 331 |
T |
CMGC/MAPK/ERK/Erk1 |
GHAIQYNTPGLKPDT |
14.667 |
10.326 |
| 231 |
T |
CMGC/CDK/CDK5 |
LVGETPLTPDGPKAN |
14.253 |
6.616 |
| 302 |
S |
TKL/STKR/STKR1 |
AVGGFAVSRFTGTDP |
11.125 |
6.85 |
| 25 |
S |
CMGC/MAPK/ERK/Erk2 |
HHHAEQTSPTQIPQS |
12.323 |
4.61 |
| 431 |
T |
AGC/GRK/BARK/BARK1 |
NPSNYVDTFDIIQET |
20.19 |
3.384 |
| 25 |
S |
CMGC/CDK/CDK5 |
HHHAEQTSPTQIPQS |
12.98 |
6.616 |
| 228 |
T |
Atypical/PIKK/FRAP |
GWKLVGETPLTPDGP |
15.694 |
8.145 |
| 231 |
T |
CMGC/CDK/CDK2/CDK2 |
LVGETPLTPDGPKAN |
13.329 |
6.826 |
| 420 |
S |
Other/Other-Unique/KIS |
IDIESNGSPHHNPSN |
12.833 |
6.008 |
| 25 |
S |
CMGC/CDK/CDK2/CDK2 |
HHHAEQTSPTQIPQS |
14.416 |
6.826 |
| 179 |
T |
CK1/CK1/CK1-D/CK1e |
TVSTAASTIASATTS |
11.647 |
4.55 |
| 202 |
T |
STE/STE20/MST/MST1 |
PIPWFGLTAQVVRNH |
14.065 |
2.612 |
| 182 |
S |
Other/CDC7 |
TAASTIASATTSTVT |
15.333 |
9.583 |
| 438 |
T |
AGC/PKC/PKCa/PRKCA |
TFDIIQETRV***** |
12.485 |
5.842 |
| 103 |
S |
Atypical/PIKK/ATR |
MFGLFNVSQMALEIP |
11.362 |
8.681 |
| 388 |
T |
Other/AUR/AurB |
KEDIARATGADIRAM |
11.241 |
7.092 |
| 231 |
T |
CMGC/CDK/CDK2/CDC28 |
LVGETPLTPDGPKAN |
12.194 |
9.411 |
| 426 |
S |
CAMK/MAPKAPK/MNK/MNK2 |
GSPHHNPSNYVDTFD |
13.286 |
6.869 |
| 27 |
T |
Other/TTK/TTK |
HAEQTSPTQIPQSEL |
49.273 |
47.968 |
| 282 |
Y |
TK/Csk/CSK |
LDNPNTKYAVLTNAA |
11.963 |
9.741 |
| 431 |
T |
AGC/GRK |
NPSNYVDTFDIIQET |
16.621 |
6.103 |
| 25 |
S |
CMGC/CDK/CDK5/CDK5 |
HHHAEQTSPTQIPQS |
13.63 |
7.867 |
| 190 |
T |
Other/TTK/TTK |
ATTSTVTTASKDPIP |
57.182 |
47.968 |
| 338 |
T |
STE/STE20/TAO/TAOK1 |
TPGLKPDTILWWAGT |
11 |
6.1 |
| 167 |
S |
AGC/GRK/GRK/GRK |
LKNALSNSNIPTTVS |
12.167 |
6.878 |
| 231 |
T |
CMGC/DYRK/DYRK2 |
LVGETPLTPDGPKAN |
13.889 |
7.053 |
| 431 |
T |
AGC/GRK/BARK |
NPSNYVDTFDIIQET |
13.023 |
3.806 |
| 438 |
T |
AGC/GRK/BARK/BARK1 |
TFDIIQETRV***** |
21.976 |
3.384 |
| 25 |
S |
CMGC/MAPK/ERK/FUS3 |
HHHAEQTSPTQIPQS |
11.667 |
3.833 |
| 167 |
S |
TKL/MLK |
LKNALSNSNIPTTVS |
16.16 |
7.138 |
| 171 |
T |
AGC/GRK/GRK/GRK |
LSNSNIPTTVSTAAS |
12.389 |
6.878 |
| 438 |
T |
AGC/GRK/BARK |
TFDIIQETRV***** |
15.488 |
3.806 |
| 420 |
S |
CMGC/MAPK/JNK/JNK3 |
IDIESNGSPHHNPSN |
11.688 |
6.781 |
| 388 |
T |
TKL/LISK/LIMK/LIMK1 |
KEDIARATGADIRAM |
11 |
6 |
| 187 |
T |
STE/STE20/MSN/MINK1 |
IASATTSTVTTASKD |
12 |
7 |
| 312 |
S |
CMGC/MAPK/ERK/Erk2 |
TGTDPMLSPHIGAMV |
13.133 |
4.61 |
| 178 |
S |
CAMK/MAPKAPK/MNK/MNK1 |
TTVSTAASTIASATT |
11.5 |
8.333 |
| 257 |
S |
CMGC/CDK/CDK5/PHO85 |
ADFKYGASPLQATLG |
11.889 |
7.061 |
| 8 |
T |
CK1/VRK/VRK2 |
MNIQPIVTSGITTQN |
17.75 |
4 |
| 184 |
T |
STE/STE20/MST/MST1 |
ASTIASATTSTVTTA |
45.484 |
2.612 |
| 428 |
Y |
TK/Eph/EphA4 |
PHHNPSNYVDTFDII |
13.75 |
6.6 |
| 431 |
T |
Atypical/PDHK/PDHK |
NPSNYVDTFDIIQET |
15.65 |
2.805 |
| 420 |
S |
CMGC/MAPK/ERK/Erk1 |
IDIESNGSPHHNPSN |
11.785 |
10.326 |
| 312 |
S |
CMGC/CDK/CDK5 |
TGTDPMLSPHIGAMV |
15.778 |
6.616 |
| 329 |
Y |
TK/PDGFR/PDGFRA |
AAGHAIQYNTPGLKP |
12.7 |
8.814 |
| 431 |
T |
STE/STE20/YSK |
NPSNYVDTFDIIQET |
12 |
6.05 |
| 60 |
T |
Other/TTK/TTK |
HAPECGETTALLSLI |
56.455 |
47.968 |
| 438 |
T |
Other/PLK |
TFDIIQETRV***** |
13.916 |
8.093 |
| 184 |
T |
CK1/CK1/CK1-D/CSNK1D |
ASTIASATTSTVTTA |
11.55 |
8.142 |
| 363 |
T |
STE/STE7/MEK3/MAP2K4 |
ETGEGRFTDYPRIWW |
11.6 |
0.017 |
| 175 |
T |
Other/PLK |
NIPTTVSTAASTIAS |
12.344 |
8.093 |
| 231 |
T |
Atypical/PIKK/FRAP |
LVGETPLTPDGPKAN |
15.361 |
8.145 |
| 182 |
S |
Other/CDC7/CDC7 |
TAASTIASATTSTVT |
15.333 |
9.583 |
| 312 |
S |
CMGC/MAPK/ERK/Erk1 |
TGTDPMLSPHIGAMV |
18.049 |
10.326 |
| 331 |
T |
CMGC/MAPK/JNK/JNK3 |
GHAIQYNTPGLKPDT |
11.812 |
6.781 |
| 171 |
T |
Other/TTK/TTK |
LSNSNIPTTVSTAAS |
49.636 |
47.968 |
| 187 |
T |
STE/STE20/MSN/TNIK |
IASATTSTVTTASKD |
12 |
7 |
| 25 |
S |
CMGC/MAPK |
HHHAEQTSPTQIPQS |
11.739 |
4.55 |
| 312 |
S |
CMGC/CDK/CDK5/PHO85 |
TGTDPMLSPHIGAMV |
11.167 |
7.061 |
| 185 |
T |
AGC/GRK/GRK/GRK |
STIASATTSTVTTAS |
12.056 |
6.878 |
| 231 |
T |
CMGC/MAPK/ERK/Erk1 |
LVGETPLTPDGPKAN |
28.556 |
10.326 |
| 438 |
T |
AGC/GRK/GRK/GRK |
TFDIIQETRV***** |
13.444 |
6.878 |
| 112 |
T |
STE/STE20/MSN/MINK1 |
MALEIPSTVPGISGK |
12 |
7 |
| 257 |
S |
CMGC/MAPK/ERK/Erk1 |
ADFKYGASPLQATLG |
18.819 |
10.326 |
| 231 |
T |
CMGC/MAPK |
LVGETPLTPDGPKAN |
13.303 |
4.55 |
| 182 |
S |
CAMK/RAD53/DUN1 |
TAASTIASATTSTVT |
11 |
6.017 |
| 231 |
T |
Other/TTK/TTK |
LVGETPLTPDGPKAN |
50.182 |
47.968 |
| 187 |
T |
STE/STE20/MSN/MAP4K4 |
IASATTSTVTTASKD |
12 |
7 |
| 25 |
S |
CMGC/MAPK/ERK/Erk1 |
HHHAEQTSPTQIPQS |
14.347 |
10.326 |
| 231 |
T |
CMGC/MAPK/JNK/JNK2 |
LVGETPLTPDGPKAN |
31.559 |
6.118 |
| 228 |
T |
CMGC/CDK/CDK5/PHO85 |
GWKLVGETPLTPDGP |
11.222 |
7.061 |
| 192 |
S |
Other/CDC7 |
TSTVTTASKDPIPWF |
11 |
9.583 |
| 431 |
T |
STE/STE20/TAO/TAOK1 |
NPSNYVDTFDIIQET |
17 |
6.1 |
| 438 |
T |
Other/PEK |
TFDIIQETRV***** |
11.818 |
2.678 |
| 329 |
Y |
TK/Csk/CTK |
AAGHAIQYNTPGLKP |
12 |
10 |
| 420 |
S |
CMGC/CDK/CDK2/CDK2 |
IDIESNGSPHHNPSN |
19.765 |
6.826 |
| 345 |
T |
Atypical/PDHK/PDHK/PDK1 |
TILWWAGTTLGLADL |
22.378 |
2.714 |
| 312 |
S |
CMGC/MAPK/JNK/JNK2 |
TGTDPMLSPHIGAMV |
44.735 |
6.118 |
| 257 |
S |
CMGC/CDK/CDK5 |
ADFKYGASPLQATLG |
13.859 |
6.616 |
| 365 |
Y |
TK/Trk/TRKA |
GEGRFTDYPRIWWHA |
12.6 |
11.95 |
| 12 |
T |
CK1/VRK/VRK2 |
PIVTSGITTQNNRHH |
18.25 |
4 |
| 112 |
T |
Other/TTK/TTK |
MALEIPSTVPGISGK |
64.545 |
47.968 |
| 9 |
S |
CK1/VRK/VRK2 |
NIQPIVTSGITTQNN |
16.75 |
4 |
| 331 |
T |
CMGC/MAPK/JNK/JNK2 |
GHAIQYNTPGLKPDT |
27.471 |
6.118 |
| 192 |
S |
Other/CDC7/CDC7 |
TSTVTTASKDPIPWF |
11 |
9.583 |
| 79 |
Y |
TK/Src/SrcB/HCK |
LLSGLDKYLAPHLEE |
11.733 |
6.378 |
| 25 |
S |
CMGC/CDK/CDK2/CDC28 |
HHHAEQTSPTQIPQS |
16.611 |
9.411 |
| 257 |
S |
CMGC/CDK/CDK5/CDK5 |
ADFKYGASPLQATLG |
13.889 |
7.867 |
| 312 |
S |
CMGC/MAPK/JNK/JNK3 |
TGTDPMLSPHIGAMV |
11.062 |
6.781 |
| 388 |
T |
STE/STE20/PAKA/PAK1 |
KEDIARATGADIRAM |
11.711 |
6.979 |
| 420 |
S |
CK1/TTBK/TTBK1 |
IDIESNGSPHHNPSN |
15.75 |
5.133 |
| 8 |
T |
Other/TTK/TTK |
MNIQPIVTSGITTQN |
52.455 |
47.968 |
| 179 |
T |
STE/STE20/MSN/MINK1 |
TVSTAASTIASATTS |
13 |
7 |
| 25 |
S |
CMGC/MAPK/JNK/JNK2 |
HHHAEQTSPTQIPQS |
31.882 |
6.118 |
| 13 |
T |
CK1 |
IVTSGITTQNNRHHH |
12.833 |
5.313 |
| 228 |
T |
CMGC/CDK/CDC2/CDK1 |
GWKLVGETPLTPDGP |
12.344 |
4.168 |
| 388 |
T |
Other/PEK |
KEDIARATGADIRAM |
15.682 |
2.678 |
| 167 |
S |
CAMK/MAPKAPK/MNK/MNK2 |
LKNALSNSNIPTTVS |
16.286 |
6.869 |
| 179 |
T |
STE/STE20/MSN/TNIK |
TVSTAASTIASATTS |
13 |
7 |
| 228 |
T |
CMGC/MAPK/ERK/Erk1 |
GWKLVGETPLTPDGP |
11.965 |
10.326 |
| 231 |
T |
CMGC/MAPK/ERK/Erk2 |
LVGETPLTPDGPKAN |
19.429 |
4.61 |
| 338 |
T |
STE/STE20/TAO |
TPGLKPDTILWWAGT |
11 |
6.1 |
| 175 |
T |
Other/TTK/TTK |
NIPTTVSTAASTIAS |
48 |
47.968 |
| 388 |
T |
TKL/LISK/LIMK |
KEDIARATGADIRAM |
11 |
6 |
| 331 |
T |
CMGC/CDK/CDK5/CDK5 |
GHAIQYNTPGLKPDT |
14.222 |
7.867 |
| 312 |
S |
CMGC/MAPK/p38/HOG1 |
TGTDPMLSPHIGAMV |
12.8 |
7.46 |
| 184 |
T |
TKL/STKR/STKR1 |
ASTIASATTSTVTTA |
13.625 |
6.85 |
| 431 |
T |
AGC/DMPK/ROCK |
NPSNYVDTFDIIQET |
12 |
6.326 |
| 165 |
S |
AGC/RSK/RSKp90/RPS6KA3 |
GPLKNALSNSNIPTT |
12.059 |
8.112 |
| 388 |
T |
AGC/DMPK/ROCK |
KEDIARATGADIRAM |
19.903 |
6.326 |
| 431 |
T |
STE/STE20/TAO |
NPSNYVDTFDIIQET |
17 |
6.1 |
* Only the results whose Scores are more than 10 are listed here.
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Pfam Domains (Experimental/Computational Results)
| id |
type |
start |
end |
| Sorry. There is no result for this protein entry. |
Mutation (Experimental Results)
| POSITION |
WILD-TYPE AA |
MUTANT |
DISEASE/NOTES |
REFERENCE |
| Sorry. There is no result for this protein entry. |
Pathway (Experimental Results)
| Pathway Accession Number |
Description |
| Sorry. There is no result for this protein entry. |
Multiple Sequence Alignments (Computational Results)
- Sorry. There is no multiple sequence alignment information for this entry.
Protein Alignment (Computational Results)
- Sorry. There is no ortholog information for this entry.
- Sorry. There is no alignment file for this entry.
