Comprehensive Information

Detailed Information (Experimental Results)

Top

Database ID24
UniProt ID A1KWQ1 
Name NleA8-2 protein
Type Type III secretion system effector (T3SE)
Gene Name nleA8-2
Organism Escherichia coli
Gene Ontology Terms -
Function -
Sequence MNIQPIVTSGITTQNNRHHHAEQTSPTQIPQSELPNGCETGFVVHIPEDMQRHAPECGETTALLSLIKDEGLLSGLDKYLAPHLEEGSAGKKALDMFGLFNVSQMALEIPSTVPGISGKYGVQLNIVKPDIHPTSGNYFLQIFPLHDEIGINFKDLPGPLKNALSNSNIPTTVSTAASTIASATTSTVTTASKDPIPWFGLTAQVVRNHGVELPIVKTENGWKLVGETPLTPDGPKANYTEEWVIRPGEADFKYGASPLQATLGLEFGAHFKWDLDNPNTKYAVLTNAAANALGAVGGFAVSRFTGTDPMLSPHIGAMVGQAAGHAIQYNTPGLKPDTILWWAGTTLGLADLNKAEFGEARFTDYPRIWWHAREGAIFPNKADIEHATGADIRAMEEGVSVGQRHPNPEDVVINIESNNSPHHNPSNYVDTVDIIQETRV
Length 440  amino acids
Reference 26120140
IBS
There is no IBS picture for this protein entry.
Sequence Alignment:

Protein Structure (Experimental Results)

Top

PDB Accession Method Resolution Chain Structure Review
Sorry. There is no result for this protein entry.

Disorder Prediction (Computational Results)

Top

Start End Sequence
396 440 EEGVSVGQRHPNPEDVVINIESNNSPHHNPSNYVDTVDIIQETRV
231 236 TPDGPK
160 191 LKNALSNSNIPTTVSTAASTIASATTSTVTTA
50 57 MQRHAPEC
83 91 HLEEGSAGK
1 41 MNIQPIVTSGITTQNNRHHHAEQTSPTQIPQSELPNGCETG

Disorder Picture (Computational Results)

Top

Kinase-specific Phosphorylation Sites (Computational Results)

Top

Position Code Kinase Peptide Score Cutoff
231 T Atypical/PIKK/FRAP LVGETPLTPDGPKAN 15.361 8.145
171 T AGC/GRK/GRK/GRK LSNSNIPTTVSTAAS 12.389 6.878
438 T Other/PEK TVDIIQETRV***** 12 2.678
167 S TKL/MLK LKNALSNSNIPTTVS 16.16 7.138
329 Y TK/PDGFR/PDGFRA AAGHAIQYNTPGLKP 12.7 8.814
178 S CAMK/MAPKAPK/MNK/MNK1 TTVSTAASTIASATT 11.5 8.333
438 T Other/PLK TVDIIQETRV***** 15.403 8.093
167 S CAMK/MAPKAPK/MNK/MNK2 LKNALSNSNIPTTVS 16.286 6.869
184 T TKL/STKR/STKR1 ASTIASATTSTVTTA 13.625 6.85
388 T Other/PEK KADIEHATGADIRAM 21.318 2.678
231 T CMGC/CDK/CDK2/CDK2 LVGETPLTPDGPKAN 13.329 6.826
184 T CK1/CK1/CK1-D/CSNK1D ASTIASATTSTVTTA 11.55 8.142
312 S CMGC/MAPK/p38/HOG1 TGTDPMLSPHIGAMV 12.8 7.46
331 T CMGC/CDK/CDK5/CDK5 GHAIQYNTPGLKPDT 14.222 7.867
231 T CMGC/CDK/CDK2/CDC28 LVGETPLTPDGPKAN 12.194 9.411
8 T Other/TTK/TTK MNIQPIVTSGITTQN 52.455 47.968
420 S CMGC/MAPK/JNK/JNK3 INIESNNSPHHNPSN 11.688 6.781
192 S Other/CDC7/CDC7 TSTVTTASKDPIPWF 11 9.583
179 T STE/STE20/MSN/MINK1 TVSTAASTIASATTS 13 7
338 T STE/STE20/TAO TPGLKPDTILWWAGT 11 6.1
365 Y TK/Trk/TRKA GEARFTDYPRIWWHA 12.6 11.95
79 Y TK/Src/SrcB/HCK LLSGLDKYLAPHLEE 11.733 6.378
420 S CMGC/CDK/CDK2/CDK2 INIESNNSPHHNPSN 22.443 6.826
171 T Other/TTK/TTK LSNSNIPTTVSTAAS 49.636 47.968
388 T AGC/DMPK/ROCK KADIEHATGADIRAM 13.903 6.326
175 T Other/PLK NIPTTVSTAASTIAS 12.344 8.093
420 S CMGC/CDK/CDK5 INIESNNSPHHNPSN 16.03 6.616
420 S CMGC/MAPK/JNK/JNK2 INIESNNSPHHNPSN 25.441 6.118
431 T AGC/GRK NPSNYVDTVDIIQET 11.922 6.103
25 S CMGC/MAPK HHHAEQTSPTQIPQS 11.739 4.55
420 S CMGC/CDK/CDK2/CDC28 INIESNNSPHHNPSN 14.806 9.411
329 Y TK/Csk/CTK AAGHAIQYNTPGLKP 12 10
312 S CMGC/CDK/CDK5 TGTDPMLSPHIGAMV 15.778 6.616
185 T AGC/GRK/GRK/GRK STIASATTSTVTTAS 12.056 6.878
231 T CMGC/DYRK/DYRK2 LVGETPLTPDGPKAN 13.889 7.053
60 T Other/TTK/TTK HAPECGETTALLSLI 56.455 47.968
312 S CMGC/CDK/CDK5/PHO85 TGTDPMLSPHIGAMV 11.167 7.061
388 T TKL/LISK/LIMK/LIMK1 KADIEHATGADIRAM 11 6
338 T STE/STE20/TAO/TAOK1 TPGLKPDTILWWAGT 11 6.1
228 T CMGC/CDK/CDK5/CDK5 GWKLVGETPLTPDGP 17.679 7.867
228 T CMGC/CDK/CDK5/PHO85 GWKLVGETPLTPDGP 11.222 7.061
228 T CMGC/MAPK/ERK/Erk1 GWKLVGETPLTPDGP 11.965 10.326
182 S Other/CDC7/CDC7 TAASTIASATTSTVT 15.333 9.583
257 S CMGC/CDK/CDK5 ADFKYGASPLQATLG 13.859 6.616
8 T CK1/VRK/VRK2 MNIQPIVTSGITTQN 17.75 4
27 T Other/TTK/TTK HAEQTSPTQIPQSEL 49.273 47.968
25 S CMGC/MAPK/ERK/FUS3 HHHAEQTSPTQIPQS 11.667 3.833
187 T STE/STE20/MSN/MAP4K4 IASATTSTVTTASKD 12 7
187 T STE/STE20/MSN/TNIK IASATTSTVTTASKD 12 7
312 S CMGC/MAPK/ERK/Erk1 TGTDPMLSPHIGAMV 18.049 10.326
190 T Other/TTK/TTK ATTSTVTTASKDPIP 57.182 47.968
331 T CMGC/CDK/CDK5/PHO85 GHAIQYNTPGLKPDT 12.778 7.061
331 T CMGC/MAPK/ERK/Erk1 GHAIQYNTPGLKPDT 14.667 10.326
282 Y TK/Src/SrcA/FGR LDNPNTKYAVLTNAA 12.4 8.74
312 S CMGC/MAPK/JNK/JNK3 TGTDPMLSPHIGAMV 11.062 6.781
438 T AGC/PKC/PKCa/PRKCA TVDIIQETRV***** 12.485 5.842
420 S CMGC/MAPK/ERK/FUS3 INIESNNSPHHNPSN 11 3.833
13 T CK1/VRK/VRK2 IVTSGITTQNNRHHH 19.25 4
187 T STE/STE20/MSN/MINK1 IASATTSTVTTASKD 12 7
257 S CMGC/MAPK/ERK/Erk1 ADFKYGASPLQATLG 18.819 10.326
438 T AGC/GRK/BARK/BARK1 TVDIIQETRV***** 21.976 3.384
363 T STE/STE7/MEK3/MAP2K4 EFGEARFTDYPRIWW 12.4 0.017
25 S CMGC/MAPK/ERK/Erk2 HHHAEQTSPTQIPQS 12.323 4.61
231 T Other/TTK/TTK LVGETPLTPDGPKAN 50.182 47.968
167 S AGC/GRK/GRK/GRK LKNALSNSNIPTTVS 12.167 6.878
112 T STE/STE20/MSN/MINK1 MALEIPSTVPGISGK 12 7
331 T CMGC/MAPK/JNK/JNK2 GHAIQYNTPGLKPDT 27.471 6.118
365 Y TK/Csk/CSK GEARFTDYPRIWWHA 11.148 9.741
257 S CMGC/CDK/CDK5/CDK5 ADFKYGASPLQATLG 13.889 7.867
257 S CMGC/CDK/CDK5/PHO85 ADFKYGASPLQATLG 11.889 7.061
331 T CK1/TTBK/TTBK1 GHAIQYNTPGLKPDT 13.625 5.133
228 T CMGC/MAPK/JNK/JNK2 GWKLVGETPLTPDGP 30.029 6.118
179 T STE/STE20/MSN/MAP4K4 TVSTAASTIASATTS 13 7
420 S CK1/TTBK/TTBK1 INIESNNSPHHNPSN 12.875 5.133
331 T CMGC/MAPK/JNK/JNK3 GHAIQYNTPGLKPDT 11.812 6.781
186 S TKL/STKR/STKR1 TIASATTSTVTTASK 11.125 6.85
112 T STE/STE20/MSN/TNIK MALEIPSTVPGISGK 12 7
182 S Other/CDC7 TAASTIASATTSTVT 15.333 9.583
231 T CMGC/MAPK/ERK/Erk1 LVGETPLTPDGPKAN 28.556 10.326
192 S Other/CDC7 TSTVTTASKDPIPWF 11 9.583
331 T CMGC/CDK/CDK5 GHAIQYNTPGLKPDT 11.152 6.616
420 S CAMK/MAPKAPK/MNK/MNK2 INIESNNSPHHNPSN 14.571 6.869
179 T STE/STE20/MSN/TNIK TVSTAASTIASATTS 13 7
184 T STE/STE20/MST/MST1 ASTIASATTSTVTTA 45.484 2.612
228 T CMGC/CDK/CDC2/CDK1 GWKLVGETPLTPDGP 12.344 4.168
420 S CMGC/CDK/CDK5/CDK5 INIESNNSPHHNPSN 16.605 7.867
388 T TKL/LISK/LIMK KADIEHATGADIRAM 11 6
25 S CMGC/MAPK/JNK/JNK3 HHHAEQTSPTQIPQS 11.688 6.781
231 T CMGC/CDK/CDK5/CDK5 LVGETPLTPDGPKAN 12.864 7.867
431 T AGC/GRK/BARK/BARK1 NPSNYVDTVDIIQET 20.19 3.384
103 S Atypical/PIKK/ATR MFGLFNVSQMALEIP 11.362 8.681
25 S CMGC/CDK/CDK5 HHHAEQTSPTQIPQS 12.98 6.616
231 T CMGC/CDK/CDK5 LVGETPLTPDGPKAN 14.253 6.616
228 T CK1/TTBK GWKLVGETPLTPDGP 12.5 3.877
312 S CMGC/MAPK/JNK/JNK2 TGTDPMLSPHIGAMV 44.735 6.118
231 T CMGC/MAPK LVGETPLTPDGPKAN 13.303 4.55
179 T CK1/CK1/CK1-D/CK1e TVSTAASTIASATTS 11.647 4.55
438 T AGC/GRK/BARK TVDIIQETRV***** 15.488 3.806
112 T Other/TTK/TTK MALEIPSTVPGISGK 64.545 47.968
312 S CMGC/MAPK/ERK/Erk2 TGTDPMLSPHIGAMV 13.133 4.61
426 S CAMK/MAPKAPK/MNK/MNK2 NSPHHNPSNYVDTVD 13.286 6.869
426 S Other/PLK NSPHHNPSNYVDTVD 15.429 8.093
187 T Other/TTK/TTK IASATTSTVTTASKD 51.182 47.968
165 S AGC/RSK/RSKp90/RPS6KA3 GPLKNALSNSNIPTT 12.059 8.112
231 T CMGC/MAPK/ERK/Erk2 LVGETPLTPDGPKAN 19.429 4.61
112 T STE/STE20/MSN/MAP4K4 MALEIPSTVPGISGK 12 7
12 T CK1/VRK/VRK2 PIVTSGITTQNNRHH 18.25 4
13 T CK1 IVTSGITTQNNRHHH 12.833 5.313
345 T Atypical/PDHK/PDHK/PDK1 TILWWAGTTLGLADL 25.865 2.714
25 S CMGC/CDK/CDK2/CDC28 HHHAEQTSPTQIPQS 16.611 9.411
182 S CAMK/RAD53/DUN1 TAASTIASATTSTVT 11 6.017
257 S CMGC/MAPK/JNK/JNK2 ADFKYGASPLQATLG 22.353 6.118
25 S CMGC/CDK/CDK2/CDK2 HHHAEQTSPTQIPQS 14.416 6.826
431 T AGC/GRK/BARK NPSNYVDTVDIIQET 13.698 3.806
282 Y TK/Csk/CSK LDNPNTKYAVLTNAA 11.963 9.741
202 T STE/STE20/MST/MST1 PIPWFGLTAQVVRNH 14.065 2.612
175 T Other/TTK/TTK NIPTTVSTAASTIAS 48 47.968
9 S CK1/VRK/VRK2 NIQPIVTSGITTQNN 16.75 4
228 T Atypical/PIKK/FRAP GWKLVGETPLTPDGP 15.694 8.145
302 S TKL/STKR/STKR1 AVGGFAVSRFTGTDP 11.125 6.85
438 T AGC/GRK/GRK/GRK TVDIIQETRV***** 13.444 6.878
231 T CMGC/MAPK/JNK/JNK2 LVGETPLTPDGPKAN 31.559 6.118
25 S CMGC/CDK/CDK5/CDK5 HHHAEQTSPTQIPQS 13.63 7.867
25 S CMGC/MAPK/ERK/Erk1 HHHAEQTSPTQIPQS 14.347 10.326
25 S CMGC/MAPK/JNK/JNK2 HHHAEQTSPTQIPQS 31.882 6.118
112 T STE/STE20/PAKA/PAK3 MALEIPSTVPGISGK 13 5.9

* Only the results whose Scores are more than 10 are listed here.

  • Click here to download the complete GPS results for this protein entry.
  • You can also go to the DOWNLOAD page to get the GPS results for all protein entries.

Pfam Domains (Experimental/Computational Results)

Top

id type start end
Sorry. There is no result for this protein entry.

Mutation (Experimental Results)

Top

POSITION WILD-TYPE AA MUTANT DISEASE/NOTES REFERENCE
Sorry. There is no result for this protein entry.

Pathway (Experimental Results)

Top

Pathway Accession Number Description
Sorry. There is no result for this protein entry.

Multiple Sequence Alignments (Computational Results)

Top

  • Sorry. There is no multiple sequence alignment information for this entry.

Protein Alignment (Computational Results)

Top

  • Sorry. There is no ortholog information for this entry.
  • Sorry. There is no alignment file for this entry.