Comprehensive Information

Detailed Information (Experimental Results)

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Database ID26
UniProt ID A1KWQ3 
Name NleA10 protein
Type Type III secretion system effector (T3SE)
Gene Name nleA10
Organism Escherichia coli
Gene Ontology Terms -
Function -
Sequence MNIQPTIQSGITTQHNQHHHTEQTPPTQIPQSELPLGCQAGFVVNIPDDIQRHAPECGETTALLGLIRDKGLLSGLDAYLAPHLEEGSAGKKALDMFGLFNVTQMALEIPSSVPGVSGKYGVQMNIVKPDIHPTTGNYVLQLFPAHDEIGINYRDLPGPLKNVLSSDAVPWFGLTAQVVRNHGVELPIVKTENGWKLVGETPLTPDGPKANYTEEWVIRPAEADLKYGTSPFQATLGLEFGAHFKWDLDNPRTKYAVLTNAAANAVGAAGGFAVSRLTGVAPMLAPHIGSMAGQAVGHAVQCNTQGLKPDTILWWAGTTLGLADLNKAETGEGRFTDYPRIWWHAREGAIFPNKEDIARATGADIRAMEEGIPVGQRHPNPEDVVIDIESNGSPHHNPSNYVDTFDIIRETRV
Length 413  amino acids
Reference 26120140
IBS
There is no IBS picture for this protein entry.
Sequence Alignment:

Protein Structure (Experimental Results)

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PDB Accession Method Resolution Chain Structure Review
Sorry. There is no result for this protein entry.

Disorder Prediction (Computational Results)

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Start End Sequence
115 117 GVS
85 91 EEGSAGK
204 209 TPDGPK
409 413 RETRV
326 332 NKAETGE
1 36 MNIQPTIQSGITTQHNQHHHTEQTPPTQIPQSELPL
113 113 V
368 401 MEEGIPVGQRHPNPEDVVIDIESNGSPHHNPSNY

Disorder Picture (Computational Results)

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Kinase-specific Phosphorylation Sites (Computational Results)

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Position Code Kinase Peptide Score Cutoff
79 Y TK/Src/SrcB/HCK LLSGLDAYLAPHLEE 12.233 6.378
411 T AGC/DMPK/ROCK TFDIIRETRV***** 17.548 6.326
399 S CAMK/MAPKAPK/MNK/MNK2 GSPHHNPSNYVDTFD 13.286 6.869
204 T Atypical/PIKK/FRAP LVGETPLTPDGPKAN 15.361 8.145
361 T TKL/LISK/LIMK/LIMK1 KEDIARATGADIRAM 11 6
404 T AGC/PDK1/PKH2 NPSNYVDTFDIIRET 13.333 5.683
393 S CMGC/CDK/CDK5 IDIESNGSPHHNPSN 15.515 6.616
212 Y TK/EGFR PDGPKANYTEEWVIR 11.41 6.45
112 S STE/STE20/PAKA/PAK3 MALEIPSSVPGVSGK 12.133 5.9
393 S CMGC/MAPK/JNK/JNK3 IDIESNGSPHHNPSN 11.688 6.781
12 T CK1 PTIQSGITTQHNQHH 13.819 5.313
399 S Other/PLK GSPHHNPSNYVDTFD 12 8.093
393 S CMGC/DYRK/DYRK2 IDIESNGSPHHNPSN 11.611 7.053
24 T CMGC/CDK/CDK5/CDK5 QHHHTEQTPPTQIPQ 12.481 7.867
404 T STE/STE20/YSK NPSNYVDTFDIIRET 12 6.05
401 Y TK/Eph/EphA4 PHHNPSNYVDTFDII 13.75 6.6
24 T CMGC/MAPK/ERK/Erk1 QHHHTEQTPPTQIPQ 13.312 10.326
404 T AGC/GRK/BARK NPSNYVDTFDIIRET 12.558 3.806
311 T STE/STE20/TAO/TAOK1 TQGLKPDTILWWAGT 11 6.1
393 S CMGC/MAPK/JNK/JNK2 IDIESNGSPHHNPSN 24.853 6.118
393 S CK1/TTBK/TTBK1 IDIESNGSPHHNPSN 15.75 5.133
230 S CMGC/CDK/CDK5/CDK5 ADLKYGTSPFQATLG 20.173 7.867
201 T CMGC/MAPK/ERK/Erk1 GWKLVGETPLTPDGP 11.965 10.326
230 S CMGC/MAPK/ERK/Erk1 ADLKYGTSPFQATLG 17.514 10.326
201 T CMGC/CDK/CDK5/CDK5 GWKLVGETPLTPDGP 17.679 7.867
13 T CK1 TIQSGITTQHNQHHH 14.646 5.313
393 S CMGC/MAPK/ERK/Erk1 IDIESNGSPHHNPSN 11.785 10.326
393 S Other/Other-Unique/KIS IDIESNGSPHHNPSN 12.833 6.008
27 T Atypical/PIKK/FRAP HTEQTPPTQIPQSEL 13.028 8.145
24 T CMGC/MAPK/ERK/Erk2 QHHHTEQTPPTQIPQ 13.181 4.61
134 T Other/TTK/TTK VKPDIHPTTGNYVLQ 48.364 47.968
12 T CK1/VRK/VRK2 PTIQSGITTQHNQHH 19.75 4
27 T Other/TTK/TTK HTEQTPPTQIPQSEL 49.273 47.968
204 T CMGC/MAPK/JNK/JNK2 LVGETPLTPDGPKAN 31.559 6.118
24 T CMGC/CDK/CDK2/CDC28 QHHHTEQTPPTQIPQ 13.611 9.411
253 T Other/Haspin WDLDNPRTKYAVLTN 15 7
6 T CK1/VRK/VRK2 **MNIQPTIQSGITT 24 4
393 S CMGC/MAPK/ERK/FUS3 IDIESNGSPHHNPSN 11.667 3.833
255 Y TK/Csk/CSK LDNPRTKYAVLTNAA 13 9.741
404 T Atypical/PDHK/PDHK NPSNYVDTFDIIRET 15.8 2.805
393 S CMGC/CDK/CDK5/CDK5 IDIESNGSPHHNPSN 16.79 7.867
201 T CMGC/CDK/CDK5/PHO85 GWKLVGETPLTPDGP 11.222 7.061
411 T AGC/GRK/GRK/GRK TFDIIRETRV***** 12.278 6.878
318 T Atypical/PDHK/PDHK/PDK1 TILWWAGTTLGLADL 22.378 2.714
230 S CMGC/MAPK/ERK/FUS3 ADLKYGTSPFQATLG 11.667 3.833
204 T CMGC/CDK/CDK2/CDC28 LVGETPLTPDGPKAN 12.194 9.411
311 T STE/STE20/TAO TQGLKPDTILWWAGT 11 6.1
230 S CMGC/CDK/CDK5/PHO85 ADLKYGTSPFQATLG 14 7.061
361 T TKL/LISK/LIMK KEDIARATGADIRAM 11 6
138 Y TK/PDGFR/PDGFRA IHPTTGNYVLQLFPA 11.2 8.814
13 T CK1/VRK/VRK2 TIQSGITTQHNQHHH 18.5 4
24 T Atypical/PIKK/FRAP QHHHTEQTPPTQIPQ 13.361 8.145
204 T Other/TTK/TTK LVGETPLTPDGPKAN 50.182 47.968
201 T CK1/TTBK GWKLVGETPLTPDGP 12.5 3.877
338 Y TK/Trk/TRKA GEGRFTDYPRIWWHA 12.6 11.95
204 T CMGC/MAPK/ERK/Erk1 LVGETPLTPDGPKAN 28.556 10.326
204 T CMGC/MAPK LVGETPLTPDGPKAN 13.303 4.55
230 S CMGC/CDK/CDK5 ADLKYGTSPFQATLG 13.182 6.616
204 T CMGC/CDK/CDK5/CDK5 LVGETPLTPDGPKAN 12.864 7.867
204 T CMGC/DYRK/DYRK2 LVGETPLTPDGPKAN 13.889 7.053
330 T Other/NEK/NEK11 ADLNKAETGEGRFTD 12.667 8.933
336 T STE/STE7/MEK3/MAP2K4 ETGEGRFTDYPRIWW 11.6 0.017
201 T CMGC/CDK/CDC2/CDK1 GWKLVGETPLTPDGP 12.344 4.168
404 T STE/STE20/TAO NPSNYVDTFDIIRET 17 6.1
230 S CMGC/MAPK/JNK/JNK2 ADLKYGTSPFQATLG 21.412 6.118
361 T Other/AUR/AurB KEDIARATGADIRAM 11.241 7.092
404 T AGC/GRK NPSNYVDTFDIIRET 17.655 6.103
201 T CMGC/MAPK/JNK/JNK2 GWKLVGETPLTPDGP 30.029 6.118
204 T CMGC/MAPK/ERK/Erk2 LVGETPLTPDGPKAN 19.429 4.61
253 T Other/Haspin/Haspin WDLDNPRTKYAVLTN 15 7
411 T AGC/GRK/BARK/BARK1 TFDIIRETRV***** 21.976 3.384
117 S AGC/DMPK/ROCK PSSVPGVSGKYGVQM 12.016 6.326
175 T STE/STE20/MST/MST1 AVPWFGLTAQVVRNH 14.839 2.612
404 T AGC/GRK/BARK/BARK1 NPSNYVDTFDIIRET 22.69 3.384
404 T STE/STE20/TAO/TAOK1 NPSNYVDTFDIIRET 17 6.1
278 T STE/STE7/MEK3/MAP2K6 GFAVSRLTGVAPMLA 11.143 5.333
361 T AGC/DMPK/ROCK KEDIARATGADIRAM 19.903 6.326
411 T AGC/PKC/PKCa/PRKCA TFDIIRETRV***** 12.995 5.842
24 T CMGC/CDK/CDC2/CDK1 QHHHTEQTPPTQIPQ 14.357 4.168
411 T Other/PEK TFDIIRETRV***** 11.273 2.678
138 Y TK/Src/SrcA/FGR IHPTTGNYVLQLFPA 11.8 8.74
411 T AGC/GRK/BARK TFDIIRETRV***** 15.488 3.806
255 Y TK/Fak/PYK2 LDNPRTKYAVLTNAA 11.1 8.11
112 S CAMK/CAMKL/AMPK/AMPKA2 MALEIPSSVPGVSGK 11.25 4.95
24 T CMGC/CDK/CDK4/CDK6 QHHHTEQTPPTQIPQ 11 3.967
204 T CMGC/CDK/CDK5 LVGETPLTPDGPKAN 14.253 6.616
12 T Other/TTK/TTK PTIQSGITTQHNQHH 56.182 47.968
229 T STE/STE-Unique/NIK EADLKYGTSPFQATL 11.667 4.283
111 S AGC/DMPK/ROCK QMALEIPSSVPGVSG 13.806 6.326
24 T CMGC/MAPK/JNK/JNK2 QHHHTEQTPPTQIPQ 32.206 6.118
361 T STE/STE20/PAKA/PAK1 KEDIARATGADIRAM 11.711 6.979
9 S CK1/VRK/VRK2 NIQPTIQSGITTQHN 13.75 4
393 S CMGC/CDK/CDK2/CDK2 IDIESNGSPHHNPSN 19.765 6.826
153 Y TK/Trk/TRKA HDEIGINYRDLPGPL 22.4 11.95
201 T Atypical/PIKK/FRAP GWKLVGETPLTPDGP 15.694 8.145
6 T Other/PLK **MNIQPTIQSGITT 13.175 8.093
361 T Other/PEK KEDIARATGADIRAM 15.682 2.678
230 S CMGC/CDK/CDK2/CDC28 ADLKYGTSPFQATLG 11.667 9.411
60 T Other/TTK/TTK HAPECGETTALLGLI 56.455 47.968
393 S CMGC/CDK/CDK2/CDC28 IDIESNGSPHHNPSN 14.806 9.411
12 T Other/PLK PTIQSGITTQHNQHH 12.377 8.093
204 T CMGC/CDK/CDK2/CDK2 LVGETPLTPDGPKAN 13.329 6.826
404 T AGC/DMPK/ROCK NPSNYVDTFDIIRET 11.435 6.326
411 T AGC/PKC/PKCa/PRKCB TFDIIRETRV***** 13.259 8.434

* Only the results whose Scores are more than 10 are listed here.

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Pfam Domains (Experimental/Computational Results)

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id type start end
Sorry. There is no result for this protein entry.

Mutation (Experimental Results)

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POSITION WILD-TYPE AA MUTANT DISEASE/NOTES REFERENCE
Sorry. There is no result for this protein entry.

Pathway (Experimental Results)

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Pathway Accession Number Description
Sorry. There is no result for this protein entry.

Multiple Sequence Alignments (Computational Results)

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  • Sorry. There is no multiple sequence alignment information for this entry.

Protein Alignment (Computational Results)

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  • Sorry. There is no ortholog information for this entry.
  • Sorry. There is no alignment file for this entry.