Comprehensive Information

Detailed Information (Experimental Results)

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Database ID27
UniProt ID A1KWQ4 
Name NleA11 protein
Type Type III secretion system effector (T3SE)
Gene Name nleA11
Organism Escherichia coli
Gene Ontology Terms -
Function -
Sequence MNIQPTIQSGITTQHNQHHHTEQTPPTQIPQSELPLGCQAGFVVNIPDDIQQHAPECGETTVLLSLIKDKGLLSGLDAYIAPHLEEGSAGKKALDMFGLFNVTQMALEIPSSTVPGISGKYGVQMNIVKPDIHPTSGNYFLQIFPLHDEIGFNFKDLPGPLKNALSNSNISTTAVSTIASTGTSATTSTVTTEPKDPIPWFGLTAQVVRNHGVELPIVKTENGWKLVGEAPLTPDGPKANYTEEWVIRPGEADFKYGTSPLQATLGLEFGAHFKWDLDNPNTKYAILTNAAANALGAAGGFAISKIPGVDPMLAPHIGAMVGQAAGHAIQCNTPGLKPDTILWWAGTTLGLADLNKAETGEARFTDYPRIWWHAREGAIFPNKEDIARATGTDIRAMEEGIPVGQRHPKPEDVVIDIESNGSPHHNPSNYVNTFDIIQETRV
Length 442  amino acids
Reference 26120140
IBS
There is no IBS picture for this protein entry.
Sequence Alignment:

Protein Structure (Experimental Results)

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PDB Accession Method Resolution Chain Structure Review
Sorry. There is no result for this protein entry.

Disorder Prediction (Computational Results)

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Start End Sequence
233 238 TPDGPK
1 38 MNIQPTIQSGITTQHNQHHHTEQTPPTQIPQSELPLGC
117 117 I
439 442 ETRV
356 359 KAET
397 429 MEEGIPVGQRHPKPEDVVIDIESNGSPHHNPSN
161 195 LKNALSNSNISTTAVSTIASTGTSATTSTVTTEPK
86 91 EGSAGK

Disorder Picture (Computational Results)

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Kinase-specific Phosphorylation Sites (Computational Results)

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Position Code Kinase Peptide Score Cutoff
433 T AGC/GRK/BARK/BARK1 NPSNYVNTFDIIQET 19.476 3.384
259 S CMGC/MAPK/ERK/FUS3 ADFKYGTSPLQATLG 11.667 3.833
233 T CMGC/CDK/CDK5 LVGEAPLTPDGPKAN 13.939 6.616
259 S CMGC/CDK/CDK5 ADFKYGTSPLQATLG 13.576 6.616
433 T AGC/GRK NPSNYVNTFDIIQET 15.509 6.103
259 S CMGC/MAPK/JNK/JNK2 ADFKYGTSPLQATLG 22.412 6.118
24 T CMGC/CDK/CDC2/CDK1 QHHHTEQTPPTQIPQ 14.357 4.168
422 S CMGC/MAPK/JNK/JNK2 IDIESNGSPHHNPSN 24.853 6.118
181 T CK1/CK1/CK1-D/CK1e AVSTIASTGTSATTS 11.647 4.55
189 T STE/STE20/MSN/MAP4K4 GTSATTSTVTTEPKD 12 7
422 S CK1/TTBK/TTBK1 IDIESNGSPHHNPSN 15.75 5.133
422 S Other/Other-Unique/KIS IDIESNGSPHHNPSN 12.833 6.008
189 T Other/TTK/TTK GTSATTSTVTTEPKD 51.182 47.968
204 T STE/STE20/MST/MST1 PIPWFGLTAQVVRNH 15.677 2.612
12 T CK1/VRK/VRK2 PTIQSGITTQHNQHH 19.75 4
333 T CMGC/MAPK/ERK/Erk1 GHAIQCNTPGLKPDT 14.764 10.326
422 S CMGC/MAPK/JNK/JNK3 IDIESNGSPHHNPSN 11.688 6.781
422 S CMGC/MAPK/ERK/FUS3 IDIESNGSPHHNPSN 11.667 3.833
433 T STE/STE20/YSK NPSNYVNTFDIIQET 17 6.05
166 S AGC/RSK/RSKp90/RPS6KA3 GPLKNALSNSNISTT 12.059 8.112
333 T CK1/TTBK/TTBK1 GHAIQCNTPGLKPDT 13.625 5.133
183 T CK1/TTBK/TTBK1 STIASTGTSATTSTV 11.75 5.133
259 S Atypical/PIKK/FRAP ADFKYGTSPLQATLG 11.667 8.145
171 S STE/STE20/MST/MST1 ALSNSNISTTAVSTI 16 2.612
422 S CMGC/DYRK/DYRK2 IDIESNGSPHHNPSN 11.611 7.053
333 T CMGC/CDK/CDK5/CDK5 GHAIQCNTPGLKPDT 14.222 7.867
189 T STE/STE20/MSN/TNIK GTSATTSTVTTEPKD 12 7
24 T CMGC/CDK/CDK5/CDK5 QHHHTEQTPPTQIPQ 12.481 7.867
433 T AGC/DMPK/ROCK NPSNYVNTFDIIQET 12.29 6.326
27 T Atypical/PIKK/FRAP HTEQTPPTQIPQSEL 13.028 8.145
390 T STE/STE20/PAKA/PAK1 KEDIARATGTDIRAM 12.342 6.979
440 T AGC/GRK/BARK TFDIIQETRV***** 15.488 3.806
177 T STE/STE20/MSN/MAP4K4 ISTTAVSTIASTGTS 13 7
233 T CMGC/MAPK LVGEAPLTPDGPKAN 13.842 4.55
365 T STE/STE7/MEK3/MAP2K4 ETGEARFTDYPRIWW 12.4 0.017
186 T CK1/CK1/CK1-D/CSNK1D ASTGTSATTSTVTTE 12.25 8.142
422 S CMGC/CDK/CDK2/CDC28 IDIESNGSPHHNPSN 14.806 9.411
259 S CMGC/CDK/CDK5/PHO85 ADFKYGTSPLQATLG 12.111 7.061
233 T CMGC/MAPK/JNK/JNK2 LVGEAPLTPDGPKAN 33.412 6.118
284 Y TK/Csk/CSK LDNPNTKYAILTNAA 11.704 9.741
24 T CMGC/MAPK/JNK/JNK2 QHHHTEQTPPTQIPQ 32.206 6.118
13 T CK1 TIQSGITTQHNQHHH 14.646 5.313
24 T Atypical/PIKK/FRAP QHHHTEQTPPTQIPQ 13.361 8.145
422 S CMGC/CDK/CDK5 IDIESNGSPHHNPSN 15.515 6.616
422 S CMGC/MAPK/ERK/Erk1 IDIESNGSPHHNPSN 11.785 10.326
390 T TKL/LISK/LIMK KEDIARATGTDIRAM 11 6
12 T Other/TTK/TTK PTIQSGITTQHNQHH 56.182 47.968
180 S CAMK/MAPKAPK/MNK/MNK1 TAVSTIASTGTSATT 11.5 8.333
422 S CMGC/CDK/CDK2/CDK2 IDIESNGSPHHNPSN 15.906 6.826
113 T STE/STE20/MSN/TNIK ALEIPSSTVPGISGK 12 7
9 S CK1/VRK/VRK2 NIQPTIQSGITTQHN 13.75 4
259 S CMGC/MAPK/ERK/Erk1 ADFKYGTSPLQATLG 16.549 10.326
177 T STE/STE20/MSN/TNIK ISTTAVSTIASTGTS 13 7
233 T CMGC/MAPK/ERK/Erk2 LVGEAPLTPDGPKAN 19.155 4.61
433 T Atypical/PDHK/PDHK NPSNYVNTFDIIQET 15.2 2.805
189 T STE/STE20/MSN/MINK1 GTSATTSTVTTEPKD 12 7
24 T CMGC/CDK/CDK2/CDC28 QHHHTEQTPPTQIPQ 13.611 9.411
24 T CMGC/CDK/CDK4/CDK6 QHHHTEQTPPTQIPQ 11 3.967
192 T Atypical/PIKK/FRAP ATTSTVTTEPKDPIP 14.139 8.145
390 T AGC/DMPK/ROCK KEDIARATGTDIRAM 19.113 6.326
60 T Atypical/PIKK/FRAP HAPECGETTVLLSLI 12.111 8.145
359 T Other/NEK/NEK11 ADLNKAETGEARFTD 14.333 8.933
440 T AGC/PKC/PKCa/PRKCA TFDIIQETRV***** 12.485 5.842
259 S CMGC/CDK/CDK5/CDK5 ADFKYGTSPLQATLG 14.346 7.867
440 T Other/PEK TFDIIQETRV***** 11.818 2.678
186 T CK1/CK1/CK1-D/CK1e ASTGTSATTSTVTTE 11.824 4.55
390 T Other/PEK KEDIARATGTDIRAM 15.682 2.678
113 T STE/STE20/MSN/MINK1 ALEIPSSTVPGISGK 12 7
166 S CAMK/MAPKAPK/MK5/MAPKAPK5 GPLKNALSNSNISTT 16.818 6.633
333 T CMGC/MAPK/JNK/JNK3 GHAIQCNTPGLKPDT 12.062 6.781
177 T Atypical/PDHK/PDHK/PDK1 ISTTAVSTIASTGTS 13.405 2.714
333 T CMGC/CDK/CDK5/PHO85 GHAIQCNTPGLKPDT 12.778 7.061
112 S CAMK/MAPKAPK/MNK/MNK1 MALEIPSSTVPGISG 11 8.333
233 T CMGC/CDK/CDK2/CDC28 LVGEAPLTPDGPKAN 12.056 9.411
367 Y TK/Trk/TRKA GEARFTDYPRIWWHA 12.6 11.95
171 S AGC/GRK/GRK/GRK ALSNSNISTTAVSTI 11.222 6.878
6 T CK1/VRK/VRK2 **MNIQPTIQSGITT 24 4
192 T Other/TTK/TTK ATTSTVTTEPKDPIP 50.273 47.968
168 S CAMK/MAPKAPK/MNK/MNK2 LKNALSNSNISTTAV 16.286 6.869
233 T CMGC/DYRK/DYRK2 LVGEAPLTPDGPKAN 13.5 7.053
430 Y TK/EGFR PHHNPSNYVNTFDII 13.229 6.45
12 T CK1 PTIQSGITTQHNQHH 13.819 5.313
60 T Other/TTK/TTK HAPECGETTVLLSLI 56.455 47.968
79 Y TK/Src/SrcB/HCK LLSGLDAYIAPHLEE 13.4 6.378
187 T AGC/GRK/GRK/GRK STGTSATTSTVTTEP 14.778 6.878
187 T TKL/STKR/STKR1 STGTSATTSTVTTEP 11.125 6.85
27 T Other/TTK/TTK HTEQTPPTQIPQSEL 49.273 47.968
440 T AGC/GRK/BARK/BARK1 TFDIIQETRV***** 21.976 3.384
233 T CMGC/CDK/CDK5/CDK5 LVGEAPLTPDGPKAN 12.864 7.867
433 T STE/STE20/TAO NPSNYVNTFDIIQET 12 6.1
233 T Other/TTK/TTK LVGEAPLTPDGPKAN 48.545 47.968
233 T CMGC/MAPK/ERK/Erk1 LVGEAPLTPDGPKAN 28.062 10.326
422 S CMGC/CDK/CDK5/CDK5 IDIESNGSPHHNPSN 16.79 7.867
340 T STE/STE20/TAO TPGLKPDTILWWAGT 11 6.1
428 S CAMK/MAPKAPK/MNK/MNK2 GSPHHNPSNYVNTFD 13.286 6.869
433 T STE/STE20/TAO/TAOK1 NPSNYVNTFDIIQET 12 6.1
340 T STE/STE20/TAO/TAOK1 TPGLKPDTILWWAGT 11 6.1
390 T TKL/LISK/LIMK/LIMK1 KEDIARATGTDIRAM 11 6
6 T Other/PLK **MNIQPTIQSGITT 13.175 8.093
168 S AGC/GRK/GRK/GRK LKNALSNSNISTTAV 11.611 6.878
166 S CAMK/MAPKAPK/MK5 GPLKNALSNSNISTT 16.818 6.633
433 T AGC/PDK1/PKH2 NPSNYVNTFDIIQET 13.667 5.683
284 Y TK/Src/SrcA/FGR LDNPNTKYAILTNAA 12.4 8.74
233 T CMGC/CDK/CDK2/CDK2 LVGEAPLTPDGPKAN 12.483 6.826
24 T CMGC/MAPK/ERK/Erk2 QHHHTEQTPPTQIPQ 13.181 4.61
428 S Other/PLK GSPHHNPSNYVNTFD 11.61 8.093
168 S TKL/STKR/STKR1 LKNALSNSNISTTAV 11.25 6.85
440 T Other/PLK TFDIIQETRV***** 14.071 8.093
183 T AGC/GRK/GRK/GRK STIASTGTSATTSTV 13.722 6.878
180 S CK1/CK1/CK1-D/CSNK1D TAVSTIASTGTSATT 11.15 8.142
113 T STE/STE20/MSN/MAP4K4 ALEIPSSTVPGISGK 12 7
183 T CK1/CK1/CK1-D/CSNK1D STIASTGTSATTSTV 16 8.142
233 T Atypical/PIKK/FRAP LVGEAPLTPDGPKAN 13.639 8.145
347 T Atypical/PDHK/PDHK/PDK1 TILWWAGTTLGLADL 23.027 2.714
440 T AGC/GRK/GRK/GRK TFDIIQETRV***** 13.444 6.878
186 T TKL/STKR/STKR1 ASTGTSATTSTVTTE 13.625 6.85
367 Y TK/Csk/CSK GEARFTDYPRIWWHA 11.148 9.741
187 T CK1/CK1/CK1-D/CSNK1D STGTSATTSTVTTEP 13.6 8.142
12 T Other/PLK PTIQSGITTQHNQHH 12.377 8.093
241 Y TK/EGFR PDGPKANYTEEWVIR 11.06 6.45
24 T CMGC/MAPK/ERK/Erk1 QHHHTEQTPPTQIPQ 13.312 10.326
13 T CK1/VRK/VRK2 TIQSGITTQHNQHHH 18.5 4
177 T STE/STE20/MSN/MINK1 ISTTAVSTIASTGTS 13 7
113 T STE/STE20/PAKA/PAK3 ALEIPSSTVPGISGK 13.267 5.9
172 T Other/TTK/TTK LSNSNISTTAVSTIA 55.545 47.968
79 Y TK/Eph/EphB1 LLSGLDAYIAPHLEE 11.333 7.967
79 Y TK/PDGFR/KIT LLSGLDAYIAPHLEE 11.625 8.15
186 T Other/PLK ASTGTSATTSTVTTE 11.292 8.093
333 T CMGC/MAPK/JNK/JNK2 GHAIQCNTPGLKPDT 26.941 6.118

* Only the results whose Scores are more than 10 are listed here.

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Pfam Domains (Experimental/Computational Results)

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id type start end
Sorry. There is no result for this protein entry.

Mutation (Experimental Results)

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POSITION WILD-TYPE AA MUTANT DISEASE/NOTES REFERENCE
Sorry. There is no result for this protein entry.

Pathway (Experimental Results)

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Pathway Accession Number Description
Sorry. There is no result for this protein entry.

Multiple Sequence Alignments (Computational Results)

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  • Sorry. There is no multiple sequence alignment information for this entry.

Protein Alignment (Computational Results)

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  • Sorry. There is no ortholog information for this entry.
  • Sorry. There is no alignment file for this entry.