Comprehensive Information

Detailed Information (Experimental Results)

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Database ID28
UniProt ID A2A0W5 
Name Tir-cytoskeleton coupling protein
Type Type III secretion system effector (T3SE)
Gene Name tccP
Organism Escherichia coli O157:H-
Gene Ontology Terms -
Function -
Sequence MINNVSSLFPTVNRNITAVYKKSSFSVSPQKITLNPVKISSPFSPSSSSISATTLFRAPNAHSASFHRQSTAESSLHQQLPNVRQRLIQHLAEHGIKPARSMAEHIPPAPNWPAPPPPVQNEQSRPLPDVAQRLVQHLAEHGIQPARNMAEHIPPAPNWPAPPLPVQNEQSRPLPDVAQRLVQHLAEHGIQPARSMAEHIPPAPNWPAPPPPVQNEQSRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHLAEHGINTSKRS
Length 337  amino acids
Reference 26120140
IBS
There is no IBS picture for this protein entry.
Sequence Alignment:

Protein Structure (Experimental Results)

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PDB Accession Method Resolution Chain Structure Review
Sorry. There is no result for this protein entry.

Disorder Prediction (Computational Results)

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Start End Sequence
1 5 MINNV
15 337 NITAVYKKSSFSVSPQKITLNPVKISSPFSPSSSSISATTLFRAPNAHSASFHRQSTAESSLHQQLPNVRQRLIQHLAEHGIKPARSMAEHIPPAPNWPAPPPPVQNEQSRPLPDVAQRLVQHLAEHGIQPARNMAEHIPPAPNWPAPPLPVQNEQSRPLPDVAQRLVQHLAEHGIQPARSMAEHIPPAPNWPAPPPPVQNEQSRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHLAEHGINTSKRS

Disorder Picture (Computational Results)

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Kinase-specific Phosphorylation Sites (Computational Results)

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Position Code Kinase Peptide Score Cutoff
312 S STE/STE20/MST PPVQNEQSRPLPDVA 18.421 3.532
334 S AGC/PKC/PKCa/PRKCB AEHGINTSKRS**** 19.224 8.434
17 T CAMK/MAPKAPK/MK5 PTVNRNITAVYKKSS 16.818 6.633
333 T AGC/PKC/PKCa/PRKCA LAEHGINTSKRS*** 25.54 5.842
257 T CMGC/CDK/CDK2/CDC28 APNWPAPTPPVQNEQ 14.056 9.411
44 S CMGC/MAPK VKISSPFSPSSSSIS 16.428 4.55
337 S Atypical/PDHK/PDHK GINTSKRS******* 11.675 2.805
7 S CK1/VRK/VRK2 *MINNVSSLFPTVNR 15.75 4
304 T CAMK/MAPKAPK/MK5 APNWPAPTPPVQNEQ 12.455 6.633
65 S AGC/PKC/PKCi APNAHSASFHRQSTA 20.938 7.442
337 S Other/PEK GINTSKRS******* 41.227 2.678
44 S CMGC/CDK/CDC2/CDK1 VKISSPFSPSSSSIS 16.136 4.168
41 S CMGC/MAPK/ERK/Erk1 LNPVKISSPFSPSSS 23.729 10.326
44 S CK1/TTBK/TTBK1 VKISSPFSPSSSSIS 12.125 5.133
28 S CMGC/MAPK/ERK/Erk1 KKSSFSVSPQKITLN 18.535 10.326
47 S CK1/TTBK/TTBK1 SSPFSPSSSSISATT 11.625 5.133
337 S AGC/PKC/PKCa/PRKCB GINTSKRS******* 28.345 8.434
48 S AGC/GRK/GRK/GRK SPFSPSSSSISATTL 11.222 6.878
41 S CMGC/MAPK/JNK/JNK3 LNPVKISSPFSPSSS 11.562 6.781
257 T Atypical/PIKK/FRAP APNWPAPTPPVQNEQ 14.778 8.145
304 T Atypical/PIKK/FRAP APNWPAPTPPVQNEQ 14.778 8.145
28 S CMGC/CDK/CDK2/CDC28 KKSSFSVSPQKITLN 17.222 9.411
6 S Other/PLK **MINNVSSLFPTVN 18.123 8.093
337 S AGC/PKC/PKCa GINTSKRS******* 15.904 3.383
49 S TKL/STKR/STKR1 PFSPSSSSISATTLF 11.375 6.85
44 S CMGC/MAPK/JNK/JNK2 VKISSPFSPSSSSIS 30.735 6.118
28 S CMGC/MAPK/ERK/Erk4 KKSSFSVSPQKITLN 12.333 5.7
44 S CMGC/MAPK/ERK/Erk1 VKISSPFSPSSSSIS 24.174 10.326
71 T CAMK/CAMKL/PASK/PASK ASFHRQSTAESSLHQ 11.167 5.4
17 T Other/PLK PTVNRNITAVYKKSS 13.604 8.093
48 S TKL/STKR/STKR1 SPFSPSSSSISATTL 12.125 6.85
53 T Other/TTK/TTK SSSSISATTLFRAPN 52.091 47.968
6 S CK1/VRK/VRK2 **MINNVSSLFPTVN 19 4
28 S CMGC/MAPK/JNK/JNK2 KKSSFSVSPQKITLN 31.029 6.118
337 S AGC/PKC/PKCa/PRKCA GINTSKRS******* 35.682 5.842
44 S Atypical/PIKK/FRAP VKISSPFSPSSSSIS 21.833 8.145
44 S CMGC/MAPK/ERK/Erk5 VKISSPFSPSSSSIS 20.059 4.757
47 S STE/STE20/PAKA/CLA4 SSPFSPSSSSISATT 14.875 3.825
257 T CMGC/MAPK/ERK/Erk1 APNWPAPTPPVQNEQ 13.646 10.326
333 T AGC/GRK LAEHGINTSKRS*** 13.853 6.103
44 S Other/NEK/NEK11 VKISSPFSPSSSSIS 13 8.933
337 S AGC/GRK/GRK/GRK GINTSKRS******* 12.611 6.878
304 T CMGC/CDK/CDK2/CDC28 APNWPAPTPPVQNEQ 14.056 9.411
44 S CMGC/CDK/CDK2/CDC28 VKISSPFSPSSSSIS 11.028 9.411
17 T CAMK/MAPKAPK/MK5/MAPKAPK5 PTVNRNITAVYKKSS 16.818 6.633
24 S Atypical/PDHK/PDHK TAVYKKSSFSVSPQK 22.775 2.805
70 S Other/AUR/AurB SASFHRQSTAESSLH 11.741 7.092
48 S CAMK/MAPKAPK/MNK/MNK2 SPFSPSSSSISATTL 11 6.869
41 S CMGC/CDK/CDK4/CDK6 LNPVKISSPFSPSSS 12.833 3.967
334 S Other/IKK AEHGINTSKRS**** 11.835 4.573
44 S CMGC/CDK/CDK2/CDK2 VKISSPFSPSSSSIS 16.356 6.826
44 S CMGC/MAPK/p38 VKISSPFSPSSSSIS 12.119 4.309
51 S Other/NEK/NEK11 SPSSSSISATTLFRA 12.667 8.933
44 S STE/STE20/PAKA/CLA4 VKISSPFSPSSSSIS 12.625 3.825
47 S CMGC/MAPK/ERK/Erk1 SSPFSPSSSSISATT 11.958 10.326
41 S CMGC/CDK/CDC2/CDK1 LNPVKISSPFSPSSS 11.318 4.168
304 T CMGC/MAPK/ERK/Erk2 APNWPAPTPPVQNEQ 18.522 4.61
11 T Other/TTK/TTK NVSSLFPTVNRNITA 50.909 47.968
6 S CAMK/MAPKAPK/MNK/MNK2 **MINNVSSLFPTVN 11 6.869
337 S AGC/GRK/BARK GINTSKRS******* 14.186 3.806
71 T CMGC/DYRK/DYRK2 ASFHRQSTAESSLHQ 14.333 7.053
74 S Other/CDC7/CDC7 HRQSTAESSLHQQLP 11.667 9.583
44 S CMGC/CDK/CDK5 VKISSPFSPSSSSIS 22.838 6.616
71 T CAMK/CAMKL/PASK ASFHRQSTAESSLHQ 11.833 4.1
304 T STE/STE20/MST/MST1 APNWPAPTPPVQNEQ 28.29 2.612
71 T CAMK/MAPKAPK ASFHRQSTAESSLHQ 12.779 6.36
257 T CMGC/CDK/CDK5/CDK5 APNWPAPTPPVQNEQ 16.235 7.867
17 T AGC/GRK/GRK/GRK PTVNRNITAVYKKSS 14.556 6.878
44 S CMGC/MAPK/ERK/Erk2 VKISSPFSPSSSSIS 25.92 4.61
257 T CAMK/MAPKAPK/MK5/MAPKAPK5 APNWPAPTPPVQNEQ 12.455 6.633
41 S CMGC/MAPK/ERK/FUS3 LNPVKISSPFSPSSS 11.333 3.833
304 T CMGC/CDK/CDC2/CDK1 APNWPAPTPPVQNEQ 11.331 4.168
41 S CMGC/CDK/CDK5/PHO85 LNPVKISSPFSPSSS 15.611 7.061
20 Y TK/Fak/FAK NRNITAVYKKSSFSV 14.062 4.398
257 T STE/STE20/MST/MST1 APNWPAPTPPVQNEQ 28.29 2.612
41 S CMGC/MAPK LNPVKISSPFSPSSS 13.086 4.55
41 S CMGC/CDK/CDC2 LNPVKISSPFSPSSS 11.53 4.698
11 T CK1/VRK/VRK2 NVSSLFPTVNRNITA 16.75 4
334 S AGC/GRK/BARK/BARK1 AEHGINTSKRS**** 24.5 3.384
334 S Other/PEK AEHGINTSKRS**** 32.091 2.678
28 S CMGC/CDK/CDK5 KKSSFSVSPQKITLN 19.939 6.616
337 S AGC/PKC/PKCi GINTSKRS******* 11.75 7.442
334 S Other/PLK AEHGINTSKRS**** 11.727 8.093
257 T CAMK/MAPKAPK/MK5 APNWPAPTPPVQNEQ 12.455 6.633
334 S AGC/PKC/PKCa/PRKCA AEHGINTSKRS**** 23.818 5.842
304 T CMGC/CDK/CDK5/CDK5 APNWPAPTPPVQNEQ 16.235 7.867
333 T AGC/GRK/BARK LAEHGINTSKRS*** 11.023 3.806
28 S CMGC/CDK/CDK2/CDK2 KKSSFSVSPQKITLN 15.107 6.826
28 S CMGC/CDK/CDK5/CDK5 KKSSFSVSPQKITLN 19.877 7.867
304 T CMGC/MAPK/JNK/JNK2 APNWPAPTPPVQNEQ 36.647 6.118
41 S CMGC/MAPK/ERK/Erk5 LNPVKISSPFSPSSS 12.235 4.757
337 S AGC/GRK/BARK/BARK1 GINTSKRS******* 24.429 3.384
41 S CMGC/MAPK/JNK/JNK2 LNPVKISSPFSPSSS 27.029 6.118
257 T CMGC/CDK/CDC2/CDK1 APNWPAPTPPVQNEQ 11.331 4.168
257 T CMGC/MAPK/JNK/JNK2 APNWPAPTPPVQNEQ 36.647 6.118
334 S AGC/GRK/BARK AEHGINTSKRS**** 15.512 3.806
304 T CAMK/MAPKAPK/MK5/MAPKAPK5 APNWPAPTPPVQNEQ 12.455 6.633
44 S CMGC/CDK/CDK5/CDK5 VKISSPFSPSSSSIS 18.259 7.867
41 S CMGC/CDK/CDK5/CDK5 LNPVKISSPFSPSSS 17.531 7.867
334 S AGC/GRK AEHGINTSKRS**** 16.621 6.103
337 S AGC/GRK GINTSKRS******* 14.216 6.103
74 S Other/CDC7 HRQSTAESSLHQQLP 11.667 9.583
28 S CMGC/MAPK/p38/HOG1 KKSSFSVSPQKITLN 13.2 7.46
48 S STE/STE7/MEK3/MAP2K3 SPFSPSSSSISATTL 14.556 1.477
333 T AGC/GRK/BARK/BARK1 LAEHGINTSKRS*** 19.786 3.384
7 S TKL/MLK *MINNVSSLFPTVNR 14.4 7.138
44 S CMGC/CDK/CDC2 VKISSPFSPSSSSIS 12.832 4.698
40 S CAMK/CAMKL/AMPK/AMPKA2 TLNPVKISSPFSPSS 11 4.95
41 S CMGC/CDK/CDK2/CDC28 LNPVKISSPFSPSSS 16.389 9.411
304 T CMGC/MAPK/ERK/Erk1 APNWPAPTPPVQNEQ 13.646 10.326
257 T CMGC/MAPK/ERK/Erk2 APNWPAPTPPVQNEQ 18.522 4.61
24 S AGC/PKC/PKCi TAVYKKSSFSVSPQK 12.771 7.442

* Only the results whose Scores are more than 10 are listed here.

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Pfam Domains (Experimental/Computational Results)

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id type start end
EspF Pfam 71 95
EspF Pfam 284 330
EspF Pfam 190 236
EspF Pfam 96 142
EspF Pfam 143 189
EspF Pfam 237 283

Mutation (Experimental Results)

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POSITION WILD-TYPE AA MUTANT DISEASE/NOTES REFERENCE
Sorry. There is no result for this protein entry.

Pathway (Experimental Results)

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Pathway Accession Number Description
Sorry. There is no result for this protein entry.

Multiple Sequence Alignments (Computational Results)

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Protein Alignment (Computational Results)

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