Comprehensive Information

Detailed Information (Experimental Results)

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Database ID29
UniProt ID A2A0W7 
Name Tir-cytoskeleton coupling protein
Type Type III secretion system effector (T3SE)
Gene Name tccP
Organism Escherichia coli O157:H-
Gene Ontology Terms -
Function -
Sequence MINNVSSLFPTVNRNITAVYKKSSFSVSPQKITLNPVKISSPFSPSSSSISATTLFRAPNAHSASFHRQSTAESSLHQQLPNVRQRLIQHLAEHGIKPARSMAEHIPPAPNWPAPPPPVQNEQSRPLPDVAQRLVQHLAEHGIQPARNMAEHIPPAPNWPAPPLPVQNEQSRPLPDVAQRLVQHLAEHGIQPARSMAEHIPPAPNWPAPPPPVQNEQSRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHPAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHLAEHGINTSKRS
Length 384  amino acids
Reference 24391954
IBS
There is no IBS picture for this protein entry.
Sequence Alignment:

Protein Structure (Experimental Results)

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PDB Accession Method Resolution Chain Structure Review
Sorry. There is no result for this protein entry.

Disorder Prediction (Computational Results)

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Start End Sequence
1 5 MINNV
15 384 NITAVYKKSSFSVSPQKITLNPVKISSPFSPSSSSISATTLFRAPNAHSASFHRQSTAESSLHQQLPNVRQRLIQHLAEHGIKPARSMAEHIPPAPNWPAPPPPVQNEQSRPLPDVAQRLVQHLAEHGIQPARNMAEHIPPAPNWPAPPLPVQNEQSRPLPDVAQRLVQHLAEHGIQPARSMAEHIPPAPNWPAPPPPVQNEQSRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHPAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHLAEHGINTSKRS

Disorder Picture (Computational Results)

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Kinase-specific Phosphorylation Sites (Computational Results)

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Position Code Kinase Peptide Score Cutoff
44 S CMGC/MAPK VKISSPFSPSSSSIS 16.428 4.55
381 S AGC/GRK/BARK AEHGINTSKRS**** 15.512 3.806
44 S CMGC/CDK/CDC2 VKISSPFSPSSSSIS 12.832 4.698
28 S CMGC/CDK/CDK5 KKSSFSVSPQKITLN 19.939 6.616
257 T CMGC/CDK/CDK5/CDK5 APNWPAPTPPVQNEQ 16.235 7.867
20 Y TK/Fak/FAK NRNITAVYKKSSFSV 14.062 4.398
24 S AGC/PKC/PKCi TAVYKKSSFSVSPQK 12.771 7.442
304 T CMGC/MAPK/ERK/Erk1 APNWPAPTPPVQNEQ 13.646 10.326
28 S CMGC/MAPK/JNK/JNK2 KKSSFSVSPQKITLN 31.029 6.118
384 S AGC/GRK GINTSKRS******* 14.216 6.103
380 T AGC/GRK LAEHGINTSKRS*** 13.853 6.103
384 S AGC/PKC/PKCi GINTSKRS******* 11.75 7.442
49 S TKL/STKR/STKR1 PFSPSSSSISATTLF 11.375 6.85
380 T AGC/GRK/BARK/BARK1 LAEHGINTSKRS*** 19.786 3.384
71 T CAMK/CAMKL/PASK/PASK ASFHRQSTAESSLHQ 11.167 5.4
381 S AGC/GRK/BARK/BARK1 AEHGINTSKRS**** 24.5 3.384
17 T Other/PLK PTVNRNITAVYKKSS 13.604 8.093
257 T Atypical/PIKK/FRAP APNWPAPTPPVQNEQ 14.778 8.145
44 S CMGC/MAPK/p38 VKISSPFSPSSSSIS 12.119 4.309
44 S CMGC/CDK/CDK2/CDK2 VKISSPFSPSSSSIS 16.356 6.826
47 S STE/STE20/PAKA/CLA4 SSPFSPSSSSISATT 14.875 3.825
41 S CMGC/MAPK/ERK/FUS3 LNPVKISSPFSPSSS 11.333 3.833
51 S Other/NEK/NEK11 SPSSSSISATTLFRA 12.667 8.933
304 T CAMK/MAPKAPK/MK5/MAPKAPK5 APNWPAPTPPVQNEQ 12.455 6.633
41 S CMGC/CDK/CDC2 LNPVKISSPFSPSSS 11.53 4.698
384 S AGC/PKC/PKCa/PRKCA GINTSKRS******* 35.682 5.842
44 S Other/NEK/NEK11 VKISSPFSPSSSSIS 13 8.933
381 S AGC/PKC/PKCa/PRKCB AEHGINTSKRS**** 19.224 8.434
384 S AGC/GRK/BARK/BARK1 GINTSKRS******* 24.429 3.384
28 S CMGC/MAPK/ERK/Erk1 KKSSFSVSPQKITLN 18.535 10.326
257 T CMGC/CDK/CDC2/CDK1 APNWPAPTPPVQNEQ 11.331 4.168
17 T AGC/GRK/GRK/GRK PTVNRNITAVYKKSS 14.556 6.878
257 T CMGC/CDK/CDK2/CDC28 APNWPAPTPPVQNEQ 14.056 9.411
74 S Other/CDC7 HRQSTAESSLHQQLP 11.667 9.583
71 T CMGC/DYRK/DYRK2 ASFHRQSTAESSLHQ 14.333 7.053
6 S CK1/VRK/VRK2 **MINNVSSLFPTVN 19 4
44 S Atypical/PIKK/FRAP VKISSPFSPSSSSIS 21.833 8.145
257 T STE/STE20/MST/MST1 APNWPAPTPPVQNEQ 28.29 2.612
44 S STE/STE20/PAKA/CLA4 VKISSPFSPSSSSIS 12.625 3.825
257 T CMGC/MAPK/JNK/JNK2 APNWPAPTPPVQNEQ 36.647 6.118
6 S CAMK/MAPKAPK/MNK/MNK2 **MINNVSSLFPTVN 11 6.869
44 S CMGC/MAPK/ERK/Erk2 VKISSPFSPSSSSIS 25.92 4.61
351 T CAMK/MAPKAPK/MK5/MAPKAPK5 APNWPAPTPPVQNEQ 12.455 6.633
381 S AGC/PKC/PKCa/PRKCA AEHGINTSKRS**** 23.818 5.842
44 S CMGC/MAPK/JNK/JNK2 VKISSPFSPSSSSIS 30.735 6.118
381 S Other/IKK AEHGINTSKRS**** 11.835 4.573
44 S CMGC/CDK/CDK2/CDC28 VKISSPFSPSSSSIS 11.028 9.411
28 S CMGC/CDK/CDK2/CDC28 KKSSFSVSPQKITLN 17.222 9.411
48 S STE/STE7/MEK3/MAP2K3 SPFSPSSSSISATTL 14.556 1.477
41 S CMGC/MAPK LNPVKISSPFSPSSS 13.086 4.55
304 T CMGC/CDK/CDC2/CDK1 APNWPAPTPPVQNEQ 11.331 4.168
351 T CMGC/MAPK/ERK/Erk2 APNWPAPTPPVQNEQ 18.522 4.61
48 S CAMK/MAPKAPK/MNK/MNK2 SPFSPSSSSISATTL 11 6.869
257 T CAMK/MAPKAPK/MK5 APNWPAPTPPVQNEQ 12.455 6.633
304 T Atypical/PIKK/FRAP APNWPAPTPPVQNEQ 14.778 8.145
6 S Other/PLK **MINNVSSLFPTVN 18.123 8.093
351 T Atypical/PIKK/FRAP APNWPAPTPPVQNEQ 14.778 8.145
44 S CMGC/CDK/CDK5 VKISSPFSPSSSSIS 22.838 6.616
384 S AGC/PKC/PKCa/PRKCB GINTSKRS******* 28.345 8.434
48 S TKL/STKR/STKR1 SPFSPSSSSISATTL 12.125 6.85
257 T CMGC/MAPK/ERK/Erk1 APNWPAPTPPVQNEQ 13.646 10.326
40 S CAMK/CAMKL/AMPK/AMPKA2 TLNPVKISSPFSPSS 11 4.95
351 T CMGC/MAPK/JNK/JNK2 APNWPAPTPPVQNEQ 36.647 6.118
257 T CMGC/MAPK/ERK/Erk2 APNWPAPTPPVQNEQ 18.522 4.61
28 S CMGC/MAPK/p38/HOG1 KKSSFSVSPQKITLN 13.2 7.46
380 T AGC/PKC/PKCa/PRKCA LAEHGINTSKRS*** 25.54 5.842
384 S AGC/GRK/BARK GINTSKRS******* 14.186 3.806
65 S AGC/PKC/PKCi APNAHSASFHRQSTA 20.938 7.442
47 S CMGC/MAPK/ERK/Erk1 SSPFSPSSSSISATT 11.958 10.326
41 S CMGC/MAPK/JNK/JNK2 LNPVKISSPFSPSSS 27.029 6.118
381 S Other/PLK AEHGINTSKRS**** 11.727 8.093
359 S STE/STE20/MST PPVQNEQSRPLPDVA 18.421 3.532
41 S CMGC/CDK/CDK5/CDK5 LNPVKISSPFSPSSS 17.531 7.867
304 T CMGC/CDK/CDK5/CDK5 APNWPAPTPPVQNEQ 16.235 7.867
7 S TKL/MLK *MINNVSSLFPTVNR 14.4 7.138
28 S CMGC/CDK/CDK5/CDK5 KKSSFSVSPQKITLN 19.877 7.867
47 S CK1/TTBK/TTBK1 SSPFSPSSSSISATT 11.625 5.133
304 T CMGC/CDK/CDK2/CDC28 APNWPAPTPPVQNEQ 14.056 9.411
351 T CMGC/CDK/CDK2/CDC28 APNWPAPTPPVQNEQ 14.056 9.411
74 S Other/CDC7/CDC7 HRQSTAESSLHQQLP 11.667 9.583
381 S Other/PEK AEHGINTSKRS**** 32.091 2.678
7 S CK1/VRK/VRK2 *MINNVSSLFPTVNR 15.75 4
11 T CK1/VRK/VRK2 NVSSLFPTVNRNITA 16.75 4
41 S CMGC/MAPK/ERK/Erk5 LNPVKISSPFSPSSS 12.235 4.757
304 T CAMK/MAPKAPK/MK5 APNWPAPTPPVQNEQ 12.455 6.633
381 S AGC/GRK AEHGINTSKRS**** 16.621 6.103
17 T CAMK/MAPKAPK/MK5/MAPKAPK5 PTVNRNITAVYKKSS 16.818 6.633
41 S CMGC/MAPK/ERK/Erk1 LNPVKISSPFSPSSS 23.729 10.326
11 T Other/TTK/TTK NVSSLFPTVNRNITA 50.909 47.968
41 S CMGC/MAPK/JNK/JNK3 LNPVKISSPFSPSSS 11.562 6.781
44 S CMGC/MAPK/ERK/Erk1 VKISSPFSPSSSSIS 24.174 10.326
44 S CK1/TTBK/TTBK1 VKISSPFSPSSSSIS 12.125 5.133
384 S AGC/PKC/PKCa GINTSKRS******* 15.904 3.383
304 T STE/STE20/MST/MST1 APNWPAPTPPVQNEQ 28.29 2.612
41 S CMGC/CDK/CDK2/CDC28 LNPVKISSPFSPSSS 16.389 9.411
53 T Other/TTK/TTK SSSSISATTLFRAPN 52.091 47.968
304 T CMGC/MAPK/JNK/JNK2 APNWPAPTPPVQNEQ 36.647 6.118
380 T AGC/GRK/BARK LAEHGINTSKRS*** 11.023 3.806
48 S AGC/GRK/GRK/GRK SPFSPSSSSISATTL 11.222 6.878
351 T STE/STE20/MST/MST1 APNWPAPTPPVQNEQ 28.29 2.612
351 T CAMK/MAPKAPK/MK5 APNWPAPTPPVQNEQ 12.455 6.633
24 S Atypical/PDHK/PDHK TAVYKKSSFSVSPQK 22.775 2.805
70 S Other/AUR/AurB SASFHRQSTAESSLH 11.741 7.092
41 S CMGC/CDK/CDK5/PHO85 LNPVKISSPFSPSSS 15.611 7.061
41 S CMGC/CDK/CDK4/CDK6 LNPVKISSPFSPSSS 12.833 3.967
44 S CMGC/CDK/CDK5/CDK5 VKISSPFSPSSSSIS 18.259 7.867
28 S CMGC/MAPK/ERK/Erk4 KKSSFSVSPQKITLN 12.333 5.7
41 S CMGC/CDK/CDC2/CDK1 LNPVKISSPFSPSSS 11.318 4.168
257 T CAMK/MAPKAPK/MK5/MAPKAPK5 APNWPAPTPPVQNEQ 12.455 6.633
351 T CMGC/CDK/CDK5/CDK5 APNWPAPTPPVQNEQ 16.235 7.867
384 S Other/PEK GINTSKRS******* 41.227 2.678
304 T CMGC/MAPK/ERK/Erk2 APNWPAPTPPVQNEQ 18.522 4.61
384 S Atypical/PDHK/PDHK GINTSKRS******* 11.675 2.805
44 S CMGC/CDK/CDC2/CDK1 VKISSPFSPSSSSIS 16.136 4.168
28 S CMGC/CDK/CDK2/CDK2 KKSSFSVSPQKITLN 15.107 6.826
71 T CAMK/CAMKL/PASK ASFHRQSTAESSLHQ 11.833 4.1
384 S AGC/GRK/GRK/GRK GINTSKRS******* 12.611 6.878
17 T CAMK/MAPKAPK/MK5 PTVNRNITAVYKKSS 16.818 6.633
351 T CMGC/MAPK/ERK/Erk1 APNWPAPTPPVQNEQ 13.646 10.326
351 T CMGC/CDK/CDC2/CDK1 APNWPAPTPPVQNEQ 11.331 4.168
71 T CAMK/MAPKAPK ASFHRQSTAESSLHQ 12.779 6.36
44 S CMGC/MAPK/ERK/Erk5 VKISSPFSPSSSSIS 20.059 4.757

* Only the results whose Scores are more than 10 are listed here.

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Pfam Domains (Experimental/Computational Results)

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id type start end
EspF Pfam 237 283
EspF Pfam 331 377
EspF Pfam 190 236
EspF Pfam 96 142
EspF Pfam 284 330
EspF Pfam 143 189
EspF Pfam 71 95

Mutation (Experimental Results)

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POSITION WILD-TYPE AA MUTANT DISEASE/NOTES REFERENCE
Sorry. There is no result for this protein entry.

Pathway (Experimental Results)

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Pathway Accession Number Description
Sorry. There is no result for this protein entry.

Multiple Sequence Alignments (Computational Results)

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Protein Alignment (Computational Results)

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