Comprehensive Information

Detailed Information (Experimental Results)

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Database ID31
UniProt ID A2A0X3 
Name Type III secreted effector protein
Type Type III secretion system effector (T3SE)
Gene Name tccP2
Organism Escherichia coli O157:H-
Gene Ontology Terms -
Function -
Sequence MINSINSFFSGLPRSISSAIRSSTFTVSQHKSTPNTVKTSSPFSPSNSPASATTIFKVKNSYTESGLQRPTSYTQSSIEKNALHRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHLAEHGINTSKRS
Length 250  amino acids
Reference 19390696
IBS
There is no IBS picture for this protein entry.
Sequence Alignment:

Protein Structure (Experimental Results)

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PDB Accession Method Resolution Chain Structure Review
Sorry. There is no result for this protein entry.

Disorder Prediction (Computational Results)

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Start End Sequence
1 250 MINSINSFFSGLPRSISSAIRSSTFTVSQHKSTPNTVKTSSPFSPSNSPASATTIFKVKNSYTESGLQRPTSYTQSSIEKNALHRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHLAEHGINTSKRS

Disorder Picture (Computational Results)

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Kinase-specific Phosphorylation Sites (Computational Results)

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Position Code Kinase Peptide Score Cutoff
33 T CMGC/CDK/CDK2/CDC28 TVSQHKSTPNTVKTS 13.639 9.411
247 S Other/IKK AEHGINTSKRS**** 11.835 4.573
7 S CK1/VRK/VRK2 *MINSINSFFSGLPR 17.5 4
24 T CAMK/RAD53/CHK2 SSAIRSSTFTVSQHK 14 4.788
72 S CMGC/DYRK/DYRK2 SGLQRPTSYTQSSIE 12.556 7.053
32 S Other/IKK/IKKb/IKBKB FTVSQHKSTPNTVKT 11.71 6.297
123 T CMGC/MAPK/ERK/Erk2 APNWPAPTPPVQNEQ 18.522 4.61
41 S CMGC/CDK/CDK2/CDK2 PNTVKTSSPFSPSNS 11.43 6.826
247 S Other/PLK AEHGINTSKRS**** 11.727 8.093
24 T STE/STE20/TAO SSAIRSSTFTVSQHK 11 6.1
41 S CMGC/MAPK/ERK/Erk1 PNTVKTSSPFSPSNS 23.41 10.326
17 S CAMK/MAPKAPK/MK5 SGLPRSISSAIRSST 19.545 6.633
33 T CMGC/MAPK/ERK/Erk5 TVSQHKSTPNTVKTS 11 4.757
4 S CK1/VRK/VRK2 ****MINSINSFFSG 23.75 4
44 S STE/STE20/PAKA/CLA4 VKTSSPFSPSNSPAS 15.5 3.825
7 S STE/STE20/YSK *MINSINSFFSGLPR 13 6.05
247 S AGC/GRK/BARK AEHGINTSKRS**** 15.512 3.806
170 T STE/STE20/MST/MST1 APNWPAPTPPVQNEQ 28.29 2.612
48 S CMGC/MAPK/ERK/Erk1 SPFSPSNSPASATTI 18.472 10.326
15 S CK1/VRK/VRK2 FFSGLPRSISSAIRS 11.75 4
41 S CMGC/MAPK/JNK/JNK2 PNTVKTSSPFSPSNS 28.088 6.118
247 S Other/PEK AEHGINTSKRS**** 32.091 2.678
250 S AGC/GRK/BARK/BARK1 GINTSKRS******* 24.429 3.384
48 S Atypical/PIKK/FRAP SPFSPSNSPASATTI 15.722 8.145
170 T Atypical/PIKK/FRAP APNWPAPTPPVQNEQ 14.778 8.145
48 S CMGC/CDK/CDK5/CDK5 SPFSPSNSPASATTI 17.531 7.867
33 T CMGC/MAPK/ERK/Erk1 TVSQHKSTPNTVKTS 20.708 10.326
48 S CAMK/MAPKAPK/MNK/MNK2 SPFSPSNSPASATTI 11 6.869
217 T CAMK/MAPKAPK/MK5 APNWPAPTPPVQNEQ 12.455 6.633
41 S CMGC/CDK/CDK5/CDK5 PNTVKTSSPFSPSNS 17.333 7.867
44 S CMGC/MAPK/ERK/Erk2 VKTSSPFSPSNSPAS 28.186 4.61
10 S Other/NEK/NEK11 NSINSFFSGLPRSIS 13.333 8.933
246 T AGC/GRK/BARK LAEHGINTSKRS*** 11.023 3.806
217 T CMGC/MAPK/ERK/Erk2 APNWPAPTPPVQNEQ 18.522 4.61
24 T STE/STE20/YSK SSAIRSSTFTVSQHK 12 6.05
4 S Other/PLK ****MINSINSFFSG 20.565 8.093
40 S Atypical/PIKK/FRAP TPNTVKTSSPFSPSN 11.556 8.145
51 S Other/CDC7 SPSNSPASATTIFKV 15.333 9.583
123 T CMGC/CDK/CDK5/CDK5 APNWPAPTPPVQNEQ 16.235 7.867
33 T CMGC/CDK/CDK5/PHO85 TVSQHKSTPNTVKTS 11.611 7.061
72 S CAMK/MAPKAPK/MK5/MAPKAPK5 SGLQRPTSYTQSSIE 12.091 6.633
33 T CMGC/MAPK/ERK/Erk2 TVSQHKSTPNTVKTS 11.668 4.61
250 S AGC/GRK/GRK/GRK GINTSKRS******* 12.611 6.878
123 T CAMK/MAPKAPK/MK5/MAPKAPK5 APNWPAPTPPVQNEQ 12.455 6.633
24 T AGC/PKC/PKCi SSAIRSSTFTVSQHK 13.604 7.442
44 S CMGC/MAPK/p38 VKTSSPFSPSNSPAS 13.311 4.309
44 S CMGC/MAPK/ERK/Erk1 VKTSSPFSPSNSPAS 22.132 10.326
17 S CAMK/CAMKL SGLPRSISSAIRSST 16.276 6.355
41 S CMGC/MAPK PNTVKTSSPFSPSNS 11.805 4.55
72 S Atypical/PIKK/FRAP SGLQRPTSYTQSSIE 16.944 8.145
170 T CMGC/CDK/CDK5/CDK5 APNWPAPTPPVQNEQ 16.235 7.867
123 T CAMK/MAPKAPK/MK5 APNWPAPTPPVQNEQ 12.455 6.633
32 S CMGC/CDK/CDK4/CDK6 FTVSQHKSTPNTVKT 13.167 3.967
71 T STE/STE20/PAKA ESGLQRPTSYTQSSI 12.093 6.397
17 S AGC/RSK/MSK/RPS6KA5 SGLPRSISSAIRSST 12.852 8.69
72 S CAMK/CAMKL/CHK1 SGLQRPTSYTQSSIE 13.552 8.03
17 S AGC/PKC/PKCi SGLPRSISSAIRSST 11.167 7.442
7 S Other/PLK *MINSINSFFSGLPR 15.766 8.093
170 T CAMK/MAPKAPK/MK5/MAPKAPK5 APNWPAPTPPVQNEQ 12.455 6.633
123 T Atypical/PIKK/FRAP APNWPAPTPPVQNEQ 14.778 8.145
41 S CMGC/MAPK/ERK/Erk2 PNTVKTSSPFSPSNS 11.735 4.61
48 S CMGC/CDK/CDK5 SPFSPSNSPASATTI 23.97 6.616
15 S AGC/PKC/PKCa/PRKCB FFSGLPRSISSAIRS 11.069 8.434
32 S CAMK/RAD53/CHK2 FTVSQHKSTPNTVKT 15.773 4.788
4 S CK1 ****MINSINSFFSG 11.785 5.313
44 S Atypical/PIKK/FRAP VKTSSPFSPSNSPAS 16.917 8.145
48 S Other/PLK SPFSPSNSPASATTI 12.961 8.093
250 S AGC/PKC/PKCa/PRKCA GINTSKRS******* 35.682 5.842
33 T CMGC/CDK/CDK2/CDK2 TVSQHKSTPNTVKTS 13.55 6.826
170 T CAMK/MAPKAPK/MK5 APNWPAPTPPVQNEQ 12.455 6.633
51 S Other/CDC7/CDC7 SPSNSPASATTIFKV 15.333 9.583
71 T CK1/CK1/CK1-D/CSNK1D ESGLQRPTSYTQSSI 12.5 8.142
41 S Atypical/PIKK/FRAP PNTVKTSSPFSPSNS 16.222 8.145
41 S CMGC/CDK/CDK2/CDC28 PNTVKTSSPFSPSNS 18.222 9.411
26 T Other/TTK/TTK AIRSSTFTVSQHKST 53.636 47.968
17 S AGC/RSK/RSKp70/RPS6KB2 SGLPRSISSAIRSST 12 5.033
246 T AGC/GRK LAEHGINTSKRS*** 13.853 6.103
41 S CMGC/MAPK/p38 PNTVKTSSPFSPSNS 11.074 4.309
41 S CMGC/CDK/CDK5/PHO85 PNTVKTSSPFSPSNS 15.611 7.061
17 S CAMK/MAPKAPK SGLPRSISSAIRSST 16.636 6.36
44 S CMGC/CDK/CDC2 VKTSSPFSPSNSPAS 11.811 4.698
33 T CMGC/CDK/CDC2/CDK1 TVSQHKSTPNTVKTS 14.155 4.168
170 T CMGC/CDK/CDC2/CDK1 APNWPAPTPPVQNEQ 11.331 4.168
48 S CMGC/MAPK/ERK/Erk2 SPFSPSNSPASATTI 16.606 4.61
28 S Atypical/PIKK/ATR RSSTFTVSQHKSTPN 11.362 8.681
170 T CMGC/MAPK/ERK/Erk1 APNWPAPTPPVQNEQ 13.646 10.326
72 S CAMK/MAPKAPK/MK5 SGLQRPTSYTQSSIE 12.091 6.633
40 S STE/STE20/MST TPNTVKTSSPFSPSN 33.158 3.532
41 S CMGC/MAPK/ERK/FUS3 PNTVKTSSPFSPSNS 11.333 3.833
33 T CMGC/CDK/CDK5/CDK5 TVSQHKSTPNTVKTS 12.568 7.867
24 T STE/STE20/TAO/TAOK1 SSAIRSSTFTVSQHK 11 6.1
48 S CMGC/CDK/CDK4/CDK6 SPFSPSNSPASATTI 12.333 3.967
51 S Other/NEK/NEK11 SPSNSPASATTIFKV 12.667 8.933
247 S AGC/GRK/BARK/BARK1 AEHGINTSKRS**** 24.5 3.384
170 T CMGC/MAPK/ERK/Erk2 APNWPAPTPPVQNEQ 18.522 4.61
33 T CMGC/MAPK/JNK/JNK2 TVSQHKSTPNTVKTS 29.676 6.118
217 T CMGC/CDK/CDC2/CDK1 APNWPAPTPPVQNEQ 11.331 4.168
217 T CMGC/MAPK/ERK/Erk1 APNWPAPTPPVQNEQ 13.646 10.326
24 T AGC/PDK1/PKH2 SSAIRSSTFTVSQHK 12.667 5.683
41 S CMGC/MAPK/ERK/Erk5 PNTVKTSSPFSPSNS 11.647 4.757
170 T CMGC/CDK/CDK2/CDC28 APNWPAPTPPVQNEQ 14.056 9.411
44 S CMGC/CDK/CDK5 VKTSSPFSPSNSPAS 25.444 6.616
48 S CMGC/CDK/CDK5/PHO85 SPFSPSNSPASATTI 12 7.061
170 T CMGC/MAPK/JNK/JNK2 APNWPAPTPPVQNEQ 36.647 6.118
123 T STE/STE20/MST/MST1 APNWPAPTPPVQNEQ 28.29 2.612
63 T CAMK/CAMKL FKVKNSYTESGLQRP 12.281 6.355
4 S Other/NEK/NEK11 ****MINSINSFFSG 13.667 8.933
48 S CMGC/MAPK/ERK/FUS3 SPFSPSNSPASATTI 11 3.833
71 T STE/STE20/PAKA/PAK1 ESGLQRPTSYTQSSI 13.342 6.979
44 S CMGC/CDK/CDK5/CDK5 VKTSSPFSPSNSPAS 17.519 7.867
40 S CAMK/CAMKL/AMPK/AMPKA2 TPNTVKTSSPFSPSN 11 4.95
26 T STE/STE20/MST/MST1 AIRSSTFTVSQHKST 30 2.612
250 S AGC/GRK GINTSKRS******* 14.216 6.103
17 S CAMK/CAMKL/CHK1 SGLPRSISSAIRSST 11.172 8.03
217 T CMGC/CDK/CDK5/CDK5 APNWPAPTPPVQNEQ 16.235 7.867
123 T CMGC/CDK/CDK2/CDC28 APNWPAPTPPVQNEQ 14.056 9.411
53 T STE/STE20/PAKA/PAK3 SNSPASATTIFKVKN 13.533 5.9
250 S AGC/PKC/PKCi GINTSKRS******* 11.75 7.442
44 S CMGC/MAPK/JNK/JNK2 VKTSSPFSPSNSPAS 36.735 6.118
24 T CAMK/CAMKL SSAIRSSTFTVSQHK 17.171 6.355
41 S CMGC/CDK/CDC2/CDK1 PNTVKTSSPFSPSNS 12.895 4.168
23 S CAMK/MAPKAPK/MNK/MNK1 ISSAIRSSTFTVSQH 11 8.333
72 S AGC/RSK/RSKp90/RPS6KA3 SGLQRPTSYTQSSIE 12.529 8.112
217 T Atypical/PIKK/FRAP APNWPAPTPPVQNEQ 14.778 8.145
51 S STE/STE20/MST/MST1 SPSNSPASATTIFKV 18.839 2.612
250 S AGC/GRK/BARK GINTSKRS******* 14.186 3.806
250 S AGC/PKC/PKCa/PRKCB GINTSKRS******* 28.345 8.434
48 S CMGC/CDK/CDK2/CDK2 SPFSPSNSPASATTI 14.933 6.826
250 S AGC/PKC/PKCa GINTSKRS******* 15.904 3.383
48 S CMGC/CDK/CDK2/CDC28 SPFSPSNSPASATTI 14.083 9.411
247 S AGC/PKC/PKCa/PRKCB AEHGINTSKRS**** 19.224 8.434
48 S CMGC/MAPK/JNK/JNK2 SPFSPSNSPASATTI 41.618 6.118
17 S CAMK/MAPKAPK/MK5/MAPKAPK5 SGLPRSISSAIRSST 19.545 6.633
44 S CMGC/MAPK/ERK/Erk5 VKTSSPFSPSNSPAS 17.824 4.757
250 S Other/PEK GINTSKRS******* 41.227 2.678
10 S CK1/VRK/VRK2 NSINSFFSGLPRSIS 12.25 4
44 S CMGC/CDK/CDK2/CDK2 VKTSSPFSPSNSPAS 19.383 6.826
44 S CMGC/CDK/CDC2/CDK1 VKTSSPFSPSNSPAS 17.142 4.168
44 S CMGC/CDK/CDK2/CDC28 VKTSSPFSPSNSPAS 13.917 9.411
74 T AGC/RSK/RSKp70 LQRPTSYTQSSIEKN 11.237 3.694
123 T CMGC/MAPK/ERK/Erk1 APNWPAPTPPVQNEQ 13.646 10.326
51 S CAMK/RAD53/DUN1 SPSNSPASATTIFKV 11 6.017
123 T CMGC/CDK/CDC2/CDK1 APNWPAPTPPVQNEQ 11.331 4.168
44 S CMGC/MAPK VKTSSPFSPSNSPAS 16.578 4.55
250 S Atypical/PDHK/PDHK GINTSKRS******* 11.675 2.805
247 S AGC/PKC/PKCa/PRKCA AEHGINTSKRS**** 23.818 5.842
63 T CAMK/MAPKAPK FKVKNSYTESGLQRP 11.753 6.36
246 T AGC/GRK/BARK/BARK1 LAEHGINTSKRS*** 19.786 3.384
36 T Other/TTK/TTK QHKSTPNTVKTSSPF 61.182 47.968
123 T CMGC/MAPK/JNK/JNK2 APNWPAPTPPVQNEQ 36.647 6.118
247 S AGC/GRK AEHGINTSKRS**** 16.621 6.103
22 S AGC/GRK/GRK/GRK SISSAIRSSTFTVSQ 12.889 6.878
217 T CAMK/MAPKAPK/MK5/MAPKAPK5 APNWPAPTPPVQNEQ 12.455 6.633
217 T CMGC/CDK/CDK2/CDC28 APNWPAPTPPVQNEQ 14.056 9.411
246 T AGC/PKC/PKCa/PRKCA LAEHGINTSKRS*** 25.54 5.842
217 T CMGC/MAPK/JNK/JNK2 APNWPAPTPPVQNEQ 36.647 6.118
225 S STE/STE20/MST PPVQNEQSRPLPDVA 18.421 3.532
39 T TKL/MLK STPNTVKTSSPFSPS 19.68 7.138
217 T STE/STE20/MST/MST1 APNWPAPTPPVQNEQ 28.29 2.612
7 S TKL/MLK *MINSINSFFSGLPR 14.08 7.138

* Only the results whose Scores are more than 10 are listed here.

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Pfam Domains (Experimental/Computational Results)

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id type start end
EspF Pfam 150 196
EspF Pfam 103 149
EspF Pfam 197 243
EspF Pfam 76 102

Mutation (Experimental Results)

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POSITION WILD-TYPE AA MUTANT DISEASE/NOTES REFERENCE
Sorry. There is no result for this protein entry.

Pathway (Experimental Results)

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Pathway Accession Number Description
Sorry. There is no result for this protein entry.

Multiple Sequence Alignments (Computational Results)

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Protein Alignment (Computational Results)

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