Comprehensive Information

Detailed Information (Experimental Results)

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Database ID32
UniProt ID A2A0X5 
Name Type III secreted effector protein
Type Type III secretion system effector (T3SE)
Gene Name tccP2
Organism Escherichia coli O157:H-
Gene Ontology Terms -
Function -
Sequence MINSINSFFSGLPRSISSAIRSSTFTVSQHKSTPNTVKTSSPFSPSNSPASATTIFKVKNSYTESGLQRPTSYTQSSIEKNALHRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPPPPVQNEQSRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPPPPVQNEQSRPLPDVAQRLMQHLAEHGINTSKRS
Length 438  amino acids
Reference 26120140
IBS
There is no IBS picture for this protein entry.
Sequence Alignment:

Protein Structure (Experimental Results)

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PDB Accession Method Resolution Chain Structure Review
Sorry. There is no result for this protein entry.

Disorder Prediction (Computational Results)

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Start End Sequence
1 438 MINSINSFFSGLPRSISSAIRSSTFTVSQHKSTPNTVKTSSPFSPSNSPASATTIFKVKNSYTESGLQRPTSYTQSSIEKNALHRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPPPPVQNEQSRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLMQHLAEHGIQPARNMAEHIPPAPNWPAPPPPVQNEQSRPLPDVAQRLMQHLAEHGINTSKRS

Disorder Picture (Computational Results)

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Kinase-specific Phosphorylation Sites (Computational Results)

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Position Code Kinase Peptide Score Cutoff
264 T Atypical/PIKK/FRAP APNWPAPTPPVQNEQ 14.778 8.145
217 T CMGC/MAPK/JNK/JNK2 APNWPAPTPPVQNEQ 36.647 6.118
74 T AGC/RSK/RSKp70 LQRPTSYTQSSIEKN 11.237 3.694
264 T CMGC/CDK/CDK2/CDC28 APNWPAPTPPVQNEQ 14.056 9.411
44 S STE/STE20/PAKA/CLA4 VKTSSPFSPSNSPAS 15.5 3.825
217 T CMGC/MAPK/ERK/Erk1 APNWPAPTPPVQNEQ 13.646 10.326
48 S CMGC/MAPK/ERK/Erk1 SPFSPSNSPASATTI 18.472 10.326
32 S Other/IKK/IKKb/IKBKB FTVSQHKSTPNTVKT 11.71 6.297
264 T STE/STE20/MST/MST1 APNWPAPTPPVQNEQ 28.29 2.612
311 T CMGC/CDK/CDK2/CDC28 APNWPAPTPPVQNEQ 14.056 9.411
24 T CAMK/CAMKL SSAIRSSTFTVSQHK 17.171 6.355
7 S STE/STE20/YSK *MINSINSFFSGLPR 13 6.05
48 S CMGC/CDK/CDK2/CDK2 SPFSPSNSPASATTI 14.933 6.826
40 S CAMK/CAMKL/AMPK/AMPKA2 TPNTVKTSSPFSPSN 11 4.95
311 T Atypical/PIKK/FRAP APNWPAPTPPVQNEQ 14.778 8.145
44 S CMGC/MAPK/p38 VKTSSPFSPSNSPAS 13.311 4.309
438 S AGC/PKC/PKCa GINTSKRS******* 15.904 3.383
4 S Other/NEK/NEK11 ****MINSINSFFSG 13.667 8.933
33 T CMGC/CDK/CDK5/CDK5 TVSQHKSTPNTVKTS 12.568 7.867
24 T AGC/PKC/PKCi SSAIRSSTFTVSQHK 13.604 7.442
217 T CAMK/MAPKAPK/MK5 APNWPAPTPPVQNEQ 12.455 6.633
358 T CMGC/MAPK/ERK/Erk1 APNWPAPTPPVQNEQ 13.646 10.326
123 T CMGC/MAPK/JNK/JNK2 APNWPAPTPPVQNEQ 36.647 6.118
358 T Atypical/PIKK/FRAP APNWPAPTPPVQNEQ 14.778 8.145
33 T CMGC/MAPK/JNK/JNK2 TVSQHKSTPNTVKTS 29.676 6.118
15 S CK1/VRK/VRK2 FFSGLPRSISSAIRS 11.75 4
217 T Atypical/PIKK/FRAP APNWPAPTPPVQNEQ 14.778 8.145
123 T CMGC/MAPK/ERK/Erk1 APNWPAPTPPVQNEQ 13.646 10.326
438 S AGC/GRK/GRK/GRK GINTSKRS******* 12.611 6.878
72 S CAMK/MAPKAPK/MK5 SGLQRPTSYTQSSIE 12.091 6.633
358 T CAMK/MAPKAPK/MK5/MAPKAPK5 APNWPAPTPPVQNEQ 12.455 6.633
434 T AGC/PKC/PKCa/PRKCA LAEHGINTSKRS*** 25.54 5.842
48 S CMGC/MAPK/JNK/JNK2 SPFSPSNSPASATTI 41.618 6.118
434 T AGC/GRK/BARK LAEHGINTSKRS*** 11.023 3.806
41 S Atypical/PIKK/FRAP PNTVKTSSPFSPSNS 16.222 8.145
44 S CMGC/MAPK/ERK/Erk1 VKTSSPFSPSNSPAS 22.132 10.326
217 T CAMK/MAPKAPK/MK5/MAPKAPK5 APNWPAPTPPVQNEQ 12.455 6.633
123 T CAMK/MAPKAPK/MK5 APNWPAPTPPVQNEQ 12.455 6.633
40 S Atypical/PIKK/FRAP TPNTVKTSSPFSPSN 11.556 8.145
51 S Other/CDC7 SPSNSPASATTIFKV 15.333 9.583
48 S CMGC/CDK/CDK4/CDK6 SPFSPSNSPASATTI 12.333 3.967
358 T CMGC/CDK/CDK2/CDC28 APNWPAPTPPVQNEQ 14.056 9.411
438 S Atypical/PDHK/PDHK GINTSKRS******* 11.675 2.805
24 T STE/STE20/TAO/TAOK1 SSAIRSSTFTVSQHK 11 6.1
48 S Other/PLK SPFSPSNSPASATTI 12.961 8.093
63 T CAMK/MAPKAPK FKVKNSYTESGLQRP 11.753 6.36
36 T Other/TTK/TTK QHKSTPNTVKTSSPF 61.182 47.968
71 T STE/STE20/PAKA/PAK1 ESGLQRPTSYTQSSI 13.342 6.979
41 S CMGC/MAPK/ERK/Erk5 PNTVKTSSPFSPSNS 11.647 4.757
264 T CAMK/MAPKAPK/MK5/MAPKAPK5 APNWPAPTPPVQNEQ 12.455 6.633
358 T CAMK/MAPKAPK/MK5 APNWPAPTPPVQNEQ 12.455 6.633
72 S CMGC/DYRK/DYRK2 SGLQRPTSYTQSSIE 12.556 7.053
41 S CMGC/MAPK/p38 PNTVKTSSPFSPSNS 11.074 4.309
44 S CMGC/MAPK/ERK/Erk5 VKTSSPFSPSNSPAS 17.824 4.757
24 T AGC/PDK1/PKH2 SSAIRSSTFTVSQHK 12.667 5.683
311 T CMGC/CDK/CDK5/CDK5 APNWPAPTPPVQNEQ 16.235 7.867
17 S CAMK/MAPKAPK/MK5/MAPKAPK5 SGLPRSISSAIRSST 19.545 6.633
311 T CMGC/CDK/CDC2/CDK1 APNWPAPTPPVQNEQ 11.331 4.168
24 T CAMK/RAD53/CHK2 SSAIRSSTFTVSQHK 14 4.788
438 S AGC/GRK/BARK/BARK1 GINTSKRS******* 24.429 3.384
44 S CMGC/CDK/CDC2 VKTSSPFSPSNSPAS 11.811 4.698
44 S Atypical/PIKK/FRAP VKTSSPFSPSNSPAS 16.917 8.145
438 S AGC/PKC/PKCa/PRKCB GINTSKRS******* 28.345 8.434
48 S CMGC/MAPK/ERK/FUS3 SPFSPSNSPASATTI 11 3.833
33 T CMGC/MAPK/ERK/Erk5 TVSQHKSTPNTVKTS 11 4.757
123 T STE/STE20/MST/MST1 APNWPAPTPPVQNEQ 28.29 2.612
17 S AGC/RSK/RSKp70/RPS6KB2 SGLPRSISSAIRSST 12 5.033
41 S CMGC/CDK/CDK5/CDK5 PNTVKTSSPFSPSNS 17.333 7.867
264 T CMGC/MAPK/ERK/Erk1 APNWPAPTPPVQNEQ 13.646 10.326
435 S AGC/GRK/BARK AEHGINTSKRS**** 15.512 3.806
438 S AGC/GRK/BARK GINTSKRS******* 14.186 3.806
17 S CAMK/CAMKL SGLPRSISSAIRSST 16.276 6.355
24 T STE/STE20/TAO SSAIRSSTFTVSQHK 11 6.1
22 S AGC/GRK/GRK/GRK SISSAIRSSTFTVSQ 12.889 6.878
435 S Other/IKK AEHGINTSKRS**** 11.835 4.573
51 S STE/STE20/MST/MST1 SPSNSPASATTIFKV 18.839 2.612
53 T STE/STE20/PAKA/PAK3 SNSPASATTIFKVKN 13.533 5.9
358 T STE/STE20/MST/MST1 APNWPAPTPPVQNEQ 28.29 2.612
41 S CMGC/MAPK/ERK/Erk2 PNTVKTSSPFSPSNS 11.735 4.61
17 S CAMK/MAPKAPK SGLPRSISSAIRSST 16.636 6.36
44 S CMGC/CDK/CDK2/CDK2 VKTSSPFSPSNSPAS 19.383 6.826
32 S CAMK/RAD53/CHK2 FTVSQHKSTPNTVKT 15.773 4.788
48 S CMGC/MAPK/ERK/Erk2 SPFSPSNSPASATTI 16.606 4.61
438 S Other/PEK GINTSKRS******* 41.227 2.678
17 S CAMK/CAMKL/CHK1 SGLPRSISSAIRSST 11.172 8.03
4 S CK1/VRK/VRK2 ****MINSINSFFSG 23.75 4
435 S AGC/PKC/PKCa/PRKCA AEHGINTSKRS**** 23.818 5.842
33 T CMGC/MAPK/ERK/Erk1 TVSQHKSTPNTVKTS 20.708 10.326
264 T CMGC/CDK/CDK5/CDK5 APNWPAPTPPVQNEQ 16.235 7.867
438 S AGC/PKC/PKCi GINTSKRS******* 11.75 7.442
435 S Other/PLK AEHGINTSKRS**** 11.727 8.093
10 S CK1/VRK/VRK2 NSINSFFSGLPRSIS 12.25 4
311 T CMGC/MAPK/ERK/Erk1 APNWPAPTPPVQNEQ 13.646 10.326
217 T CMGC/CDK/CDC2/CDK1 APNWPAPTPPVQNEQ 11.331 4.168
48 S CMGC/CDK/CDK5/PHO85 SPFSPSNSPASATTI 12 7.061
434 T AGC/GRK/BARK/BARK1 LAEHGINTSKRS*** 19.786 3.384
26 T Other/TTK/TTK AIRSSTFTVSQHKST 53.636 47.968
44 S CMGC/MAPK VKTSSPFSPSNSPAS 16.578 4.55
48 S CMGC/CDK/CDK2/CDC28 SPFSPSNSPASATTI 14.083 9.411
33 T CMGC/CDK/CDK5/PHO85 TVSQHKSTPNTVKTS 11.611 7.061
217 T CMGC/CDK/CDK5/CDK5 APNWPAPTPPVQNEQ 16.235 7.867
15 S AGC/PKC/PKCa/PRKCB FFSGLPRSISSAIRS 11.069 8.434
7 S Other/PLK *MINSINSFFSGLPR 15.766 8.093
435 S AGC/GRK AEHGINTSKRS**** 16.621 6.103
123 T CMGC/CDK/CDK5/CDK5 APNWPAPTPPVQNEQ 16.235 7.867
32 S CMGC/CDK/CDK4/CDK6 FTVSQHKSTPNTVKT 13.167 3.967
44 S CMGC/MAPK/ERK/Erk2 VKTSSPFSPSNSPAS 28.186 4.61
4 S Other/PLK ****MINSINSFFSG 20.565 8.093
358 T CMGC/CDK/CDC2/CDK1 APNWPAPTPPVQNEQ 11.331 4.168
311 T CMGC/MAPK/JNK/JNK2 APNWPAPTPPVQNEQ 36.647 6.118
40 S STE/STE20/MST TPNTVKTSSPFSPSN 33.158 3.532
438 S AGC/PKC/PKCa/PRKCA GINTSKRS******* 35.682 5.842
33 T CMGC/CDK/CDK2/CDK2 TVSQHKSTPNTVKTS 13.55 6.826
217 T STE/STE20/MST/MST1 APNWPAPTPPVQNEQ 28.29 2.612
264 T CMGC/CDK/CDC2/CDK1 APNWPAPTPPVQNEQ 11.331 4.168
44 S CMGC/MAPK/JNK/JNK2 VKTSSPFSPSNSPAS 36.735 6.118
311 T CAMK/MAPKAPK/MK5/MAPKAPK5 APNWPAPTPPVQNEQ 12.455 6.633
44 S CMGC/CDK/CDK5 VKTSSPFSPSNSPAS 25.444 6.616
71 T STE/STE20/PAKA ESGLQRPTSYTQSSI 12.093 6.397
358 T CMGC/MAPK/ERK/Erk2 APNWPAPTPPVQNEQ 18.522 4.61
17 S CAMK/MAPKAPK/MK5 SGLPRSISSAIRSST 19.545 6.633
26 T STE/STE20/MST/MST1 AIRSSTFTVSQHKST 30 2.612
51 S Other/NEK/NEK11 SPSNSPASATTIFKV 12.667 8.933
23 S CAMK/MAPKAPK/MNK/MNK1 ISSAIRSSTFTVSQH 11 8.333
434 T AGC/GRK LAEHGINTSKRS*** 13.853 6.103
72 S CAMK/CAMKL/CHK1 SGLQRPTSYTQSSIE 13.552 8.03
41 S CMGC/CDK/CDK5/PHO85 PNTVKTSSPFSPSNS 15.611 7.061
63 T CAMK/CAMKL FKVKNSYTESGLQRP 12.281 6.355
358 T CMGC/MAPK/JNK/JNK2 APNWPAPTPPVQNEQ 36.647 6.118
51 S CAMK/RAD53/DUN1 SPSNSPASATTIFKV 11 6.017
33 T CMGC/CDK/CDK2/CDC28 TVSQHKSTPNTVKTS 13.639 9.411
44 S CMGC/CDK/CDK5/CDK5 VKTSSPFSPSNSPAS 17.519 7.867
17 S AGC/PKC/PKCi SGLPRSISSAIRSST 11.167 7.442
48 S CMGC/CDK/CDK5 SPFSPSNSPASATTI 23.97 6.616
41 S CMGC/CDK/CDC2/CDK1 PNTVKTSSPFSPSNS 12.895 4.168
358 T CMGC/CDK/CDK5/CDK5 APNWPAPTPPVQNEQ 16.235 7.867
28 S Atypical/PIKK/ATR RSSTFTVSQHKSTPN 11.362 8.681
51 S Other/CDC7/CDC7 SPSNSPASATTIFKV 15.333 9.583
10 S Other/NEK/NEK11 NSINSFFSGLPRSIS 13.333 8.933
264 T CAMK/MAPKAPK/MK5 APNWPAPTPPVQNEQ 12.455 6.633
438 S AGC/GRK GINTSKRS******* 14.216 6.103
435 S Other/PEK AEHGINTSKRS**** 32.091 2.678
123 T Atypical/PIKK/FRAP APNWPAPTPPVQNEQ 14.778 8.145
123 T CAMK/MAPKAPK/MK5/MAPKAPK5 APNWPAPTPPVQNEQ 12.455 6.633
41 S CMGC/MAPK/ERK/FUS3 PNTVKTSSPFSPSNS 11.333 3.833
39 T TKL/MLK STPNTVKTSSPFSPS 19.68 7.138
4 S CK1 ****MINSINSFFSG 11.785 5.313
217 T CMGC/CDK/CDK2/CDC28 APNWPAPTPPVQNEQ 14.056 9.411
17 S AGC/RSK/MSK/RPS6KA5 SGLPRSISSAIRSST 12.852 8.69
44 S CMGC/CDK/CDC2/CDK1 VKTSSPFSPSNSPAS 17.142 4.168
41 S CMGC/CDK/CDK2/CDC28 PNTVKTSSPFSPSNS 18.222 9.411
123 T CMGC/CDK/CDK2/CDC28 APNWPAPTPPVQNEQ 14.056 9.411
264 T CMGC/MAPK/JNK/JNK2 APNWPAPTPPVQNEQ 36.647 6.118
48 S Atypical/PIKK/FRAP SPFSPSNSPASATTI 15.722 8.145
123 T CMGC/CDK/CDC2/CDK1 APNWPAPTPPVQNEQ 11.331 4.168
41 S CMGC/MAPK/JNK/JNK2 PNTVKTSSPFSPSNS 28.088 6.118
435 S AGC/PKC/PKCa/PRKCB AEHGINTSKRS**** 19.224 8.434
72 S Atypical/PIKK/FRAP SGLQRPTSYTQSSIE 16.944 8.145
435 S AGC/GRK/BARK/BARK1 AEHGINTSKRS**** 24.5 3.384
217 T CMGC/MAPK/ERK/Erk2 APNWPAPTPPVQNEQ 18.522 4.61
7 S TKL/MLK *MINSINSFFSGLPR 14.08 7.138
24 T STE/STE20/YSK SSAIRSSTFTVSQHK 12 6.05
41 S CMGC/CDK/CDK2/CDK2 PNTVKTSSPFSPSNS 11.43 6.826
41 S CMGC/MAPK PNTVKTSSPFSPSNS 11.805 4.55
48 S CAMK/MAPKAPK/MNK/MNK2 SPFSPSNSPASATTI 11 6.869
44 S CMGC/CDK/CDK2/CDC28 VKTSSPFSPSNSPAS 13.917 9.411
41 S CMGC/MAPK/ERK/Erk1 PNTVKTSSPFSPSNS 23.41 10.326
71 T CK1/CK1/CK1-D/CSNK1D ESGLQRPTSYTQSSI 12.5 8.142
123 T CMGC/MAPK/ERK/Erk2 APNWPAPTPPVQNEQ 18.522 4.61
311 T CMGC/MAPK/ERK/Erk2 APNWPAPTPPVQNEQ 18.522 4.61
311 T STE/STE20/MST/MST1 APNWPAPTPPVQNEQ 28.29 2.612
7 S CK1/VRK/VRK2 *MINSINSFFSGLPR 17.5 4
72 S AGC/RSK/RSKp90/RPS6KA3 SGLQRPTSYTQSSIE 12.529 8.112
264 T CMGC/MAPK/ERK/Erk2 APNWPAPTPPVQNEQ 18.522 4.61
311 T CAMK/MAPKAPK/MK5 APNWPAPTPPVQNEQ 12.455 6.633
72 S CAMK/MAPKAPK/MK5/MAPKAPK5 SGLQRPTSYTQSSIE 12.091 6.633
48 S CMGC/CDK/CDK5/CDK5 SPFSPSNSPASATTI 17.531 7.867
33 T CMGC/MAPK/ERK/Erk2 TVSQHKSTPNTVKTS 11.668 4.61
33 T CMGC/CDK/CDC2/CDK1 TVSQHKSTPNTVKTS 14.155 4.168

* Only the results whose Scores are more than 10 are listed here.

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Pfam Domains (Experimental/Computational Results)

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id type start end
EspF Pfam 103 149
EspF Pfam 291 337
EspF Pfam 244 290
EspF Pfam 385 431
EspF Pfam 150 196
EspF Pfam 197 243
EspF Pfam 76 102
EspF Pfam 338 384

Mutation (Experimental Results)

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POSITION WILD-TYPE AA MUTANT DISEASE/NOTES REFERENCE
Sorry. There is no result for this protein entry.

Pathway (Experimental Results)

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Pathway Accession Number Description
Sorry. There is no result for this protein entry.

Multiple Sequence Alignments (Computational Results)

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Protein Alignment (Computational Results)

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