Comprehensive Information

Detailed Information (Experimental Results)

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Database ID35
UniProt ID A2A0Y6 
Name Type III secreted effector protein
Type Type III secretion system effector (T3SE)
Gene Name tccP2
Organism Escherichia coli O111:H-
Gene Ontology Terms -
Function -
Sequence MINSINSFFSSIPRSISSVTRNSSFTASQHKSTPNTVKTSSPLSPSNSPASATTIFKVKNSYTESGLQRSTSYTQSSIEKNALHRPLPDVAKRLVQHLAEHGIQPARNMAEHIPPAPNWPAPTPPIQNEQSRPLPDVAQRLVQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLVQHLAEHGIQPARNMAEHIPPAPNWPAPTPPIQNEQSRPLPDVAQRLVQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLVQHLAEHGINTSKRS
Length 297  amino acids
Reference 26120140
IBS
There is no IBS picture for this protein entry.
Sequence Alignment:

Protein Structure (Experimental Results)

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PDB Accession Method Resolution Chain Structure Review
Sorry. There is no result for this protein entry.

Disorder Prediction (Computational Results)

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Start End Sequence
87 297 LPDVAKRLVQHLAEHGIQPARNMAEHIPPAPNWPAPTPPIQNEQSRPLPDVAQRLVQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLVQHLAEHGIQPARNMAEHIPPAPNWPAPTPPIQNEQSRPLPDVAQRLVQHLAEHGIQPARNMAEHIPPAPNWPAPTPPVQNEQSRPLPDVAQRLVQHLAEHGINTSKRS
1 83 MINSINSFFSSIPRSISSVTRNSSFTASQHKSTPNTVKTSSPLSPSNSPASATTIFKVKNSYTESGLQRSTSYTQSSIEKNAL

Disorder Picture (Computational Results)

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Kinase-specific Phosphorylation Sites (Computational Results)

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Position Code Kinase Peptide Score Cutoff
28 S Other/CDC7 RNSSFTASQHKSTPN 12.667 9.583
44 S CMGC/MAPK/ERK/Erk2 VKTSSPLSPSNSPAS 30.416 4.61
44 S CMGC/CDK/CDC2 VKTSSPLSPSNSPAS 11.811 4.698
48 S CMGC/CDK/CDK5/CDK5 SPLSPSNSPASATTI 19.864 7.867
297 S AGC/GRK GINTSKRS******* 14.414 6.103
123 T CMGC/MAPK/ERK/Erk1 APNWPAPTPPIQNEQ 13.153 10.326
48 S CMGC/MAPK/ERK/Erk2 SPLSPSNSPASATTI 17.385 4.61
72 S AGC/GRK/GRK/GRK SGLQRSTSYTQSSIE 12.889 6.878
71 T CK1/CK1/CK1-D/CSNK1D ESGLQRSTSYTQSSI 16.95 8.142
18 S Other/Wnk/Wnk4 SIPRSISSVTRNSSF 11.667 4.95
20 T CK1/VRK/VRK2 PRSISSVTRNSSFTA 12.75 4
11 S CK1/VRK/VRK2 SINSFFSSIPRSISS 14.75 4
24 S Atypical/PDHK/PDHK SSVTRNSSFTASQHK 16.5 2.805
297 S AGC/PKC/PKCi GINTSKRS******* 11.75 7.442
10 S Other/NEK/NEK11 NSINSFFSSIPRSIS 11.667 8.933
72 S CAMK/CAMKL SGLQRSTSYTQSSIE 15.659 6.355
44 S Atypical/PIKK/FRAP VKTSSPLSPSNSPAS 17.694 8.145
297 S AGC/GRK/BARK GINTSKRS******* 14.186 3.806
41 S CMGC/CDK/CDK5/PHO85 PNTVKTSSPLSPSNS 13.722 7.061
41 S CMGC/CDK/CDK2/CDC28 PNTVKTSSPLSPSNS 15.944 9.411
297 S AGC/GRK/GRK/GRK GINTSKRS******* 12.611 6.878
72 S CAMK/MAPKAPK/MK5/MAPKAPK5 SGLQRSTSYTQSSIE 12.909 6.633
4 S Other/PLK ****MINSINSFFSS 23.773 8.093
48 S CAMK/MAPKAPK/MNK/MNK2 SPLSPSNSPASATTI 11 6.869
170 T CAMK/MAPKAPK/MK5/MAPKAPK5 APNWPAPTPPVQNEQ 12.455 6.633
297 S Other/PEK GINTSKRS******* 41.227 2.678
72 S CAMK/RAD53/CHK2 SGLQRSTSYTQSSIE 11.886 4.788
44 S CMGC/CDK/CDK5/CDK5 VKTSSPLSPSNSPAS 15.247 7.867
24 S CAMK/MAPKAPK SSVTRNSSFTASQHK 15.026 6.36
33 T CMGC/MAPK/ERK/Erk1 TASQHKSTPNTVKTS 20.708 10.326
41 S CMGC/CDK/CDK5/CDK5 PNTVKTSSPLSPSNS 16.086 7.867
71 T STE/STE20/PAKA/PAK1 ESGLQRSTSYTQSSI 14.053 6.979
28 S Other/CDC7/CDC7 RNSSFTASQHKSTPN 12.667 9.583
73 Y TK/Fak/PYK2 GLQRSTSYTQSSIEK 11.8 8.11
24 S AGC/RSK/MSK/RPS6KA5 SSVTRNSSFTASQHK 11.111 8.69
63 T CAMK/MAPKAPK FKVKNSYTESGLQRS 12.377 6.36
217 T CMGC/MAPK/ERK/Erk1 APNWPAPTPPIQNEQ 13.153 10.326
4 S CK1 ****MINSINSFFSS 13.222 5.313
41 S Atypical/PIKK/FRAP PNTVKTSSPLSPSNS 22.389 8.145
40 S CAMK/CAMKL/AMPK/AMPKA2 TPNTVKTSSPLSPSN 11 4.95
10 S CK1/VRK/VRK2 NSINSFFSSIPRSIS 14.25 4
264 T CAMK/MAPKAPK/MK5 APNWPAPTPPVQNEQ 12.455 6.633
131 S STE/STE20/MST PPIQNEQSRPLPDVA 19.026 3.532
7 S CK1/VRK/VRK2 *MINSINSFFSSIPR 17.5 4
297 S Atypical/PDHK/PDHK GINTSKRS******* 11.675 2.805
33 T CMGC/MAPK/ERK/Erk5 TASQHKSTPNTVKTS 11 4.757
44 S STE/STE20/PAKA/CLA4 VKTSSPLSPSNSPAS 15.625 3.825
72 S CAMK/CAMKL/MARK/MARK3 SGLQRSTSYTQSSIE 11 5.383
170 T CMGC/CDK/CDC2/CDK1 APNWPAPTPPVQNEQ 11.331 4.168
48 S CMGC/CDK/CDK4/CDK6 SPLSPSNSPASATTI 12.333 3.967
48 S CMGC/MAPK/ERK/FUS3 SPLSPSNSPASATTI 11 3.833
63 T CAMK/CAMKL FKVKNSYTESGLQRS 12.995 6.355
17 S CAMK/CAMKL SSIPRSISSVTRNSS 12.636 6.355
294 S AGC/PKC/PKCa/PRKCA AEHGINTSKRS**** 23.818 5.842
17 S CAMK/MAPKAPK SSIPRSISSVTRNSS 20 6.36
264 T CMGC/MAPK/JNK/JNK2 APNWPAPTPPVQNEQ 36.647 6.118
24 S CAMK/MAPKAPK/MNK SSVTRNSSFTASQHK 11.444 5.685
24 S AGC/PKC/PKCi SSVTRNSSFTASQHK 20.917 7.442
72 S CAMK/CAMKL/CHK1 SGLQRSTSYTQSSIE 14.793 8.03
32 S AGC/RSK/MSK/RPS6KA5 FTASQHKSTPNTVKT 11.63 8.69
24 S CAMK/CAMKL SSVTRNSSFTASQHK 17.143 6.355
170 T Atypical/PIKK/FRAP APNWPAPTPPVQNEQ 14.778 8.145
70 S AGC/GRK/GRK/GRK TESGLQRSTSYTQSS 13.333 6.878
41 S CMGC/CDK/CDC2/CDK1 PNTVKTSSPLSPSNS 14.108 4.168
72 S AGC/RSK/MSK/RPS6KA5 SGLQRSTSYTQSSIE 11.481 8.69
24 S CAMK/CAMKL/CHK1 SSVTRNSSFTASQHK 11.103 8.03
44 S CMGC/MAPK/JNK/JNK2 VKTSSPLSPSNSPAS 37.147 6.118
33 T CMGC/CDK/CDK5 TASQHKSTPNTVKTS 13.889 6.616
33 T CMGC/CDK/CDK5/CDK5 TASQHKSTPNTVKTS 14.123 7.867
72 S CAMK/MAPKAPK/MK5 SGLQRSTSYTQSSIE 12.909 6.633
41 S CMGC/MAPK/p38 PNTVKTSSPLSPSNS 12.452 4.309
294 S Other/IKK AEHGINTSKRS**** 11.532 4.573
44 S CMGC/CDK/CDK5 VKTSSPLSPSNSPAS 24.657 6.616
44 S CMGC/CDK/CDC2/CDK1 VKTSSPLSPSNSPAS 16.866 4.168
41 S CMGC/MAPK/JNK/JNK2 PNTVKTSSPLSPSNS 28.088 6.118
170 T CMGC/CDK/CDK5/CDK5 APNWPAPTPPVQNEQ 16.235 7.867
294 S AGC/GRK/BARK/BARK1 AEHGINTSKRS**** 24.5 3.384
51 S Other/CDC7 SPSNSPASATTIFKV 15.333 9.583
294 S AGC/GRK AEHGINTSKRS**** 16.897 6.103
297 S AGC/PKC/PKCa/PRKCB GINTSKRS******* 28.345 8.434
17 S AGC/RSK/RSKp70/RPS6KB2 SSIPRSISSVTRNSS 12 5.033
217 T CMGC/MAPK/JNK/JNK2 APNWPAPTPPIQNEQ 36.647 6.118
17 S CAMK/CAMKL/CHK1 SSIPRSISSVTRNSS 11.69 8.03
41 S CMGC/CDK/CDK2/CDK2 PNTVKTSSPLSPSNS 12.738 6.826
48 S CMGC/CDK/CDK5/PHO85 SPLSPSNSPASATTI 12 7.061
217 T CAMK/MAPKAPK/MK5 APNWPAPTPPIQNEQ 12.455 6.633
264 T CMGC/CDK/CDK5/CDK5 APNWPAPTPPVQNEQ 16.235 7.867
33 T CMGC/CDK/CDK2/CDK2 TASQHKSTPNTVKTS 20.027 6.826
41 S CMGC/MAPK/ERK/Erk2 PNTVKTSSPLSPSNS 13.796 4.61
264 T CMGC/MAPK/ERK/Erk2 APNWPAPTPPVQNEQ 18.522 4.61
17 S Other/PLK SSIPRSISSVTRNSS 11.578 8.093
40 S Atypical/PIKK/FRAP TPNTVKTSSPLSPSN 11.472 8.145
293 T AGC/GRK/BARK LAEHGINTSKRS*** 11.023 3.806
123 T Atypical/PIKK/FRAP APNWPAPTPPIQNEQ 14.5 8.145
48 S CMGC/CDK/CDK5 SPLSPSNSPASATTI 24.273 6.616
264 T Atypical/PIKK/FRAP APNWPAPTPPVQNEQ 14.778 8.145
33 T CMGC/MAPK/ERK/Erk2 TASQHKSTPNTVKTS 11.668 4.61
7 S Atypical/PDHK/PDHK *MINSINSFFSSIPR 11.275 2.805
41 S CMGC/MAPK PNTVKTSSPLSPSNS 12.796 4.55
48 S CMGC/CDK/CDK2/CDC28 SPLSPSNSPASATTI 14.083 9.411
4 S Other/NEK/NEK11 ****MINSINSFFSS 13.667 8.933
297 S AGC/PKC/PKCa/PRKCA GINTSKRS******* 35.682 5.842
48 S CMGC/MAPK/JNK/JNK2 SPLSPSNSPASATTI 39.794 6.118
44 S CMGC/MAPK/ERK/Erk1 VKTSSPLSPSNSPAS 31.597 10.326
15 S CK1/VRK/VRK2 FFSSIPRSISSVTRN 11.5 4
44 S CMGC/MAPK/ERK/Erk5 VKTSSPLSPSNSPAS 17.824 4.757
264 T CAMK/MAPKAPK/MK5/MAPKAPK5 APNWPAPTPPVQNEQ 12.455 6.633
123 T CAMK/MAPKAPK/MK5 APNWPAPTPPIQNEQ 12.455 6.633
74 T AGC/RSK/RSKp70 LQRSTSYTQSSIEKN 14.079 3.694
225 S STE/STE20/MST PPIQNEQSRPLPDVA 19.026 3.532
41 S CMGC/MAPK/ERK/Erk5 PNTVKTSSPLSPSNS 12.353 4.757
48 S Atypical/PIKK/FRAP SPLSPSNSPASATTI 17 8.145
51 S Other/NEK/NEK11 SPSNSPASATTIFKV 12.667 8.933
33 T CMGC/CDK/CDK2/CDC28 TASQHKSTPNTVKTS 13.639 9.411
44 S CMGC/CDK/CDK2/CDK2 VKTSSPLSPSNSPAS 20.161 6.826
294 S Other/PEK AEHGINTSKRS**** 32.091 2.678
70 S AGC/PKC/PKCa/PRKCB TESGLQRSTSYTQSS 12.034 8.434
170 T CMGC/CDK/CDK2/CDC28 APNWPAPTPPVQNEQ 14.056 9.411
123 T CMGC/CDK/CDK5/CDK5 APNWPAPTPPIQNEQ 15.901 7.867
217 T CMGC/CDK/CDK5/CDK5 APNWPAPTPPIQNEQ 15.901 7.867
44 S CMGC/CDK/CDK2/CDC28 VKTSSPLSPSNSPAS 13.917 9.411
170 T CMGC/MAPK/JNK/JNK2 APNWPAPTPPVQNEQ 36.647 6.118
18 S CK1/VRK/VRK2 SIPRSISSVTRNSSF 12.25 4
18 S AGC/PKC/PKCa/PRKCB SIPRSISSVTRNSSF 11.534 8.434
51 S STE/STE20/MST/MST1 SPSNSPASATTIFKV 16.548 2.612
15 S STE/STE20/MST/MST1 FFSSIPRSISSVTRN 13.355 2.612
39 T TKL/MLK STPNTVKTSSPLSPS 17.16 7.138
36 T Other/TTK/TTK QHKSTPNTVKTSSPL 61.182 47.968
264 T CMGC/MAPK/ERK/Erk1 APNWPAPTPPVQNEQ 13.646 10.326
293 T AGC/PKC/PKCa/PRKCA LAEHGINTSKRS*** 25.54 5.842
217 T CMGC/CDK/CDK2/CDC28 APNWPAPTPPIQNEQ 12.917 9.411
44 S CMGC/MAPK VKTSSPLSPSNSPAS 17.681 4.55
123 T CMGC/CDK/CDK2/CDC28 APNWPAPTPPIQNEQ 12.917 9.411
24 S AGC/GRK/GRK/GRK SSVTRNSSFTASQHK 11.833 6.878
72 S AGC/RSK/RSKp70/RPS6KB2 SGLQRSTSYTQSSIE 11.333 5.033
48 S Other/PLK SPLSPSNSPASATTI 13.591 8.093
17 S CAMK/MAPKAPK/MK5 SSIPRSISSVTRNSS 22.818 6.633
170 T CMGC/MAPK/ERK/Erk1 APNWPAPTPPVQNEQ 13.646 10.326
61 S AGC/GRK/GRK/GRK TIFKVKNSYTESGLQ 11.111 6.878
264 T CMGC/CDK/CDK2/CDC28 APNWPAPTPPVQNEQ 14.056 9.411
48 S CMGC/MAPK/ERK/Erk1 SPLSPSNSPASATTI 18.472 10.326
297 S AGC/GRK/BARK/BARK1 GINTSKRS******* 24.429 3.384
217 T Atypical/PIKK/FRAP APNWPAPTPPIQNEQ 14.5 8.145
40 S STE/STE20/MST TPNTVKTSSPLSPSN 32.421 3.532
33 T CMGC/CDK/CDK5/PHO85 TASQHKSTPNTVKTS 11.611 7.061
293 T AGC/GRK LAEHGINTSKRS*** 14.422 6.103
24 S CAMK/MAPKAPK/MNK/MNK2 SSVTRNSSFTASQHK 12 6.869
123 T STE/STE20/MST/MST1 APNWPAPTPPIQNEQ 26.097 2.612
44 S CMGC/MAPK/p38 VKTSSPLSPSNSPAS 13.311 4.309
264 T CMGC/CDK/CDC2/CDK1 APNWPAPTPPVQNEQ 11.331 4.168
51 S CAMK/RAD53/DUN1 SPSNSPASATTIFKV 11 6.017
123 T CAMK/MAPKAPK/MK5/MAPKAPK5 APNWPAPTPPIQNEQ 12.455 6.633
72 S CAMK/MAPKAPK SGLQRSTSYTQSSIE 17.143 6.36
51 S Other/CDC7/CDC7 SPSNSPASATTIFKV 15.333 9.583
123 T CMGC/MAPK/ERK/Erk2 APNWPAPTPPIQNEQ 18.425 4.61
170 T CMGC/MAPK/ERK/Erk2 APNWPAPTPPVQNEQ 18.522 4.61
170 T STE/STE20/MST/MST1 APNWPAPTPPVQNEQ 28.29 2.612
123 T CMGC/MAPK/JNK/JNK2 APNWPAPTPPIQNEQ 36.647 6.118
293 T AGC/GRK/BARK/BARK1 LAEHGINTSKRS*** 19.786 3.384
48 S CMGC/CDK/CDK2/CDK2 SPLSPSNSPASATTI 15.027 6.826
7 S Other/PLK *MINSINSFFSSIPR 16.994 8.093
32 S Other/IKK/IKKb/IKBKB FTASQHKSTPNTVKT 11.871 6.297
170 T CAMK/MAPKAPK/MK5 APNWPAPTPPVQNEQ 12.455 6.633
71 T STE/STE20/PAKA ESGLQRSTSYTQSSI 13.07 6.397
217 T CMGC/MAPK/ERK/Erk2 APNWPAPTPPIQNEQ 18.425 4.61
72 S CMGC/DYRK/DYRK2 SGLQRSTSYTQSSIE 12.111 7.053
33 T CMGC/MAPK/JNK/JNK2 TASQHKSTPNTVKTS 29.676 6.118
41 S CMGC/MAPK/ERK/Erk1 PNTVKTSSPLSPSNS 22.285 10.326
17 S CAMK/MAPKAPK/MK5/MAPKAPK5 SSIPRSISSVTRNSS 22.818 6.633
297 S AGC/PKC/PKCa GINTSKRS******* 15.904 3.383
17 S CK1/CK1/CK1-D/CSNK1D SSIPRSISSVTRNSS 14.15 8.142
33 T CMGC/CDK/CDC2/CDK1 TASQHKSTPNTVKTS 14.155 4.168
4 S CK1/VRK/VRK2 ****MINSINSFFSS 23.75 4
294 S AGC/PKC/PKCa/PRKCB AEHGINTSKRS**** 19.224 8.434
7 S STE/STE20/YSK *MINSINSFFSSIPR 13 6.05
24 S AGC/RSK/RSKp90/RPS6KA3 SSVTRNSSFTASQHK 13.382 8.112
72 S AGC/RSK/RSKp90/RPS6KA3 SGLQRSTSYTQSSIE 12.324 8.112
217 T STE/STE20/MST/MST1 APNWPAPTPPIQNEQ 26.097 2.612
294 S Other/PLK AEHGINTSKRS**** 11.838 8.093
294 S AGC/GRK/BARK AEHGINTSKRS**** 15.512 3.806
10 S AGC/NDR/NDR/NDR1 NSINSFFSSIPRSIS 11 6
272 S STE/STE20/MST PPVQNEQSRPLPDVA 18.895 3.532
44 S CMGC/MAPK/p38/HOG1 VKTSSPLSPSNSPAS 12.8 7.46
24 S CAMK/RAD53/CHK2 SSVTRNSSFTASQHK 25.727 4.788
264 T STE/STE20/MST/MST1 APNWPAPTPPVQNEQ 28.29 2.612
217 T CAMK/MAPKAPK/MK5/MAPKAPK5 APNWPAPTPPIQNEQ 12.455 6.633
24 S STE/STE20/PAKB/PAK5 SSVTRNSSFTASQHK 12 4.45
41 S CMGC/MAPK/ERK/FUS3 PNTVKTSSPLSPSNS 11.333 3.833

* Only the results whose Scores are more than 10 are listed here.

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Pfam Domains (Experimental/Computational Results)

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id type start end
EspF Pfam 150 196
EspF Pfam 197 243
EspF Pfam 78 102
EspF Pfam 103 149
EspF Pfam 244 290

Mutation (Experimental Results)

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POSITION WILD-TYPE AA MUTANT DISEASE/NOTES REFERENCE
Sorry. There is no result for this protein entry.

Pathway (Experimental Results)

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Pathway Accession Number Description
Sorry. There is no result for this protein entry.

Multiple Sequence Alignments (Computational Results)

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Protein Alignment (Computational Results)

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