Comprehensive Information
Detailed Information (Experimental Results)
| Database ID | 50 |
| UniProt ID |
A3MCH6
|
| Name |
Guanine nucleotide exchange factor BopE
|
| Type |
Type III secretion system effector (T3SE)
|
| Gene Name |
bopE
|
| Organism |
Burkholderia mallei
|
| Gene Ontology Terms |
GO:0005576;GO:0005096;GO:0005085;GO:0031532;GO:0090630;GO:0009405
|
| Function |
Activator for both CDC42 and RAC1 by directly interacting with these Rho GTPases and acting as a guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, thus promoting bacterial entry into non-phagocytic cells (By similarity).
|
| Sequence |
MTYNPRIGGFTHVKQASFDVHVKRGEAQPRTSFAQQIKRIFSKIGETLGQLFRHRAPDSAPGRVRLQGVRYVGSYRPTGDAKQAIRHFVDEAVKQVAHTRTPEIRQDAEFGRQVYEATLCAIFSEAKDRFCMDPATRAGNVRPAFIEALGDAARATGLPGADKQGVFTPSGAGTNPLYTEIRLRADTLMGAELAARPEYRELQPYARQQAIDLVANALPAERSNTLVEFRQTVQTLEATYRRAAQDASRDEKGATNAADGA
|
| Length |
261 amino acids
|
| Reference |
24391954
|
| IBS |
|
Protein Structure (Experimental Results)
| PDB Accession |
Method |
Resolution |
Chain |
Structure Review |
| Sorry. There is no result for this protein entry. |
Disorder Prediction (Computational Results)
| Start |
End |
Sequence |
| 57 |
62 |
PDSAPG |
| 1 |
5 |
MTYNP |
| 219 |
261 |
PAERSNTLVEFRQTVQTLEATYRRAAQDASRDEKGATNAADGA |
| 159 |
160 |
PG |
| 24 |
30 |
RGEAQPR |
| 196 |
203 |
RPEYRELQ |
Disorder Picture (Computational Results)
Kinase-specific Phosphorylation Sites (Computational Results)
| Position |
Code |
Kinase |
Peptide |
Score |
Cutoff |
| 32 |
S |
Other/AUR/AurB |
GEAQPRTSFAQQIKR |
11.204 |
7.092 |
| 31 |
T |
CMGC/MAPK/ERK/Erk1 |
RGEAQPRTSFAQQIK |
12.556 |
10.326 |
| 17 |
S |
AGC/PKC/PKCi |
FTHVKQASFDVHVKR |
13.833 |
7.442 |
| 225 |
T |
CAMK/MAPKAPK |
LPAERSNTLVEFRQT |
15.247 |
6.36 |
| 248 |
S |
AGC/GRK/BARK |
RRAAQDASRDEKGAT |
11.233 |
3.806 |
| 11 |
T |
Atypical/PIKK/FRAP |
NPRIGGFTHVKQASF |
11.861 |
8.145 |
| 156 |
T |
TKL/LISK/LIMK |
LGDAARATGLPGADK |
11 |
6 |
| 11 |
T |
CK1/VRK/VRK2 |
NPRIGGFTHVKQASF |
17.25 |
4 |
| 225 |
T |
Other/TTK/TTK |
LPAERSNTLVEFRQT |
62.182 |
47.968 |
| 255 |
T |
AGC/GRK |
SRDEKGATNAADGA* |
21.353 |
6.103 |
| 156 |
T |
TKL/LISK/LIMK/LIMK1 |
LGDAARATGLPGADK |
11 |
6 |
| 225 |
T |
STE/STE20/YSK |
LPAERSNTLVEFRQT |
11 |
6.05 |
| 101 |
T |
CMGC/CDK/CDK5 |
KQVAHTRTPEIRQDA |
15.242 |
6.616 |
| 168 |
T |
CMGC/CDK/CDK5/CDK5 |
ADKQGVFTPSGAGTN |
15.889 |
7.867 |
| 187 |
T |
AGC/PDK1/PKH1 |
EIRLRADTLMGAELA |
11.333 |
4.167 |
| 32 |
S |
AGC/PKC/PKCi |
GEAQPRTSFAQQIKR |
14.438 |
7.442 |
| 118 |
T |
Other/CAMKK/Meta |
GRQVYEATLCAIFSE |
11.556 |
4.531 |
| 2 |
T |
CK1/VRK/VRK2 |
******MTYNPRIGG |
27.25 |
4 |
| 187 |
T |
STE/STE20/TAO/TAOK1 |
EIRLRADTLMGAELA |
11 |
6.1 |
| 101 |
T |
CMGC/MAPK/JNK/JNK2 |
KQVAHTRTPEIRQDA |
28.176 |
6.118 |
| 248 |
S |
AGC/PKC/PKCa/PRKCA |
RRAAQDASRDEKGAT |
12.697 |
5.842 |
| 118 |
T |
Other/CAMKK/Meta/CaMKK1 |
GRQVYEATLCAIFSE |
11.833 |
4.419 |
| 101 |
T |
CMGC/MAPK/ERK/Erk4 |
KQVAHTRTPEIRQDA |
13 |
5.7 |
| 17 |
S |
AGC/PKC/PKCa/PRKCB |
FTHVKQASFDVHVKR |
14.379 |
8.434 |
| 225 |
T |
Other/NEK/NEK9/NEK9 |
LPAERSNTLVEFRQT |
11 |
5.767 |
| 168 |
T |
CMGC/MAPK/p38/MAPK11 |
ADKQGVFTPSGAGTN |
14.778 |
5.425 |
| 71 |
Y |
TK/PDGFR/PDGFRA |
VRLQGVRYVGSYRPT |
11.3 |
8.814 |
| 17 |
S |
AGC/NDR |
FTHVKQASFDVHVKR |
11.2 |
3.983 |
| 225 |
T |
CMGC/DYRK/DYRK2 |
LPAERSNTLVEFRQT |
12.778 |
7.053 |
| 2 |
T |
Other/PLK |
******MTYNPRIGG |
11.682 |
8.093 |
| 32 |
S |
CAMK/RAD53/CHK2 |
GEAQPRTSFAQQIKR |
12.955 |
4.788 |
| 225 |
T |
Other/NEK/NEK9 |
LPAERSNTLVEFRQT |
11 |
5.767 |
| 168 |
T |
CMGC/CDK/CDK5 |
ADKQGVFTPSGAGTN |
16.384 |
6.616 |
| 235 |
T |
Other/TTK/TTK |
EFRQTVQTLEATYRR |
53.727 |
47.968 |
| 168 |
T |
CMGC/CDK/CDK2/CDK2 |
ADKQGVFTPSGAGTN |
11.832 |
6.826 |
| 118 |
T |
Other/CAMKK/Meta/CaMKK2 |
GRQVYEATLCAIFSE |
12.5 |
5.017 |
| 187 |
T |
STE/STE20/TAO |
EIRLRADTLMGAELA |
11 |
6.1 |
| 3 |
Y |
TK/Trk/TRKA |
*****MTYNPRIGGF |
13.4 |
11.95 |
| 255 |
T |
AGC/PKC/PKCa/PRKCA |
SRDEKGATNAADGA* |
13.803 |
5.842 |
| 101 |
T |
CMGC/MAPK/ERK/Erk1 |
KQVAHTRTPEIRQDA |
18.347 |
10.326 |
| 168 |
T |
CMGC/MAPK/JNK/JNK2 |
ADKQGVFTPSGAGTN |
33.794 |
6.118 |
| 240 |
Y |
TK/Met/RON |
VQTLEATYRRAAQDA |
13.5 |
9.3 |
| 232 |
T |
STE/STE20/MST |
TLVEFRQTVQTLEAT |
12.132 |
3.532 |
| 255 |
T |
Other/TTK/TTK |
SRDEKGATNAADGA* |
53.818 |
47.968 |
| 239 |
T |
AGC/PKC/PKCa/PRKCB |
TVQTLEATYRRAAQD |
12.172 |
8.434 |
| 232 |
T |
Other/TTK/TTK |
TLVEFRQTVQTLEAT |
59.091 |
47.968 |
| 31 |
T |
STE/STE20/PAKA/CLA4 |
RGEAQPRTSFAQQIK |
11.875 |
3.825 |
| 199 |
Y |
TK/Csk/CSK |
ELAARPEYRELQPYA |
15.222 |
9.741 |
| 240 |
Y |
TK/Csk/CSK |
VQTLEATYRRAAQDA |
12.037 |
9.741 |
| 47 |
T |
Other/NEK/NEK11 |
IFSKIGETLGQLFRH |
14.667 |
8.933 |
| 187 |
T |
CAMK/CAMKL/CHK1 |
EIRLRADTLMGAELA |
11.448 |
8.03 |
| 168 |
T |
CMGC/MAPK/ERK/Erk2 |
ADKQGVFTPSGAGTN |
11.535 |
4.61 |
| 115 |
Y |
TK/Trk/TRKA |
AEFGRQVYEATLCAI |
15.8 |
11.95 |
| 115 |
Y |
TK/Syk/SYK |
AEFGRQVYEATLCAI |
12.151 |
5 |
| 101 |
T |
CMGC/CDK/CDK5/CDK5 |
KQVAHTRTPEIRQDA |
12.099 |
7.867 |
| 255 |
T |
AGC/GRK/BARK/BARK1 |
SRDEKGATNAADGA* |
26.095 |
3.384 |
* Only the results whose Scores are more than 10 are listed here.
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Pfam Domains (Experimental/Computational Results)
| id |
type |
start |
end |
| SopE_GEF |
Pfam |
85 |
245 |
Mutation (Experimental Results)
| POSITION |
WILD-TYPE AA |
MUTANT |
DISEASE/NOTES |
REFERENCE |
| Sorry. There is no result for this protein entry. |
Pathway (Experimental Results)
| Pathway Accession Number |
Description |
| Sorry. There is no result for this protein entry. |
Multiple Sequence Alignments (Computational Results)
Protein Alignment (Computational Results)
