Comprehensive Information
Detailed Information (Experimental Results)
| Database ID | 56 |
| UniProt ID |
A3NLD5
|
| Name |
Translocator protein BipB
|
| Type |
Type III secretion system effector (T3SE)
|
| Gene Name |
bipB
|
| Organism |
Burkholderia pseudomallei
|
| Gene Ontology Terms |
GO:0005576;GO:0033644;GO:0016021;GO:0009405
|
| Function |
Plays a role in the bacterium-induced formation of multinucleated giant cell (MNGC), which is formed after host cell fusion, as well as in the intercellular spreading of bacteria and in the induction of apoptosis in macrophages. May act in concert with other effector proteins to induce fusion of host cell membranes (By similarity).
|
| Sequence |
MSSGVQGGPAAHANAYQTHPLRDAASALGTLSPQAYVDVVSAAQRNFLERMSQLASEQCDAQPAAHDARLDDRPALRAPQERDAPPLGASDTGSRASGAAKLTELLGVLMSVISASSLDELKQRSDIWNQMSKAAQDNLSRLSDAFQRATDEAKAAADAAEQAAAAAKQAGADAKAADAAVDAAQKRYDDAVKQGLPDDQLQSLKAALEQARQQAGDAHGRADALQADATKKLDAASALATQARACEQQVDDAVNQATQQYGASASLRTPQSPRLSGAAELTAVLGKLQELISSGNVKELESKQKLFTEMQAKREAELQKKSDEYQAQVKKAEEMQKTMGCIGKIVGWVITAVSFAAAAFTGGASLALAAVGLALAVGDEISRATTGVSFMDKLMQPVMDAILKPLMEMISSLITKALVACGVDQQKAELAGAILGAVVTGVALVAAAFVGASAVKAVASKVIDAMAGQLTKLMDSAIGKMLVQLIEKFSEKSGLQALGSRTATAMTRMRRAIGVEAKEDGMLLANRFEKAGTVMNVGNQVSQAAGGIVVGVERAKAMGLLADVKEAMYDIKLLGDLLKQAVDAFAEHNRVLAQLMQQMSDAGEMQTSTGKLILRNARAV
|
| Length |
620 amino acids
|
| Reference |
-
|
| IBS |
|
Protein Structure (Experimental Results)
| PDB Accession |
Method |
Resolution |
Chain |
Structure Review |
| Sorry. There is no result for this protein entry. |
Disorder Prediction (Computational Results)
| Start |
End |
Sequence |
| 599 |
609 |
MSDAGEMQTST |
| 513 |
519 |
IGVEAKE |
| 488 |
509 |
KFSEKSGLQALGSRTATAMTRM |
| 616 |
620 |
NARAV |
| 1 |
27 |
MSSGVQGGPAAHANAYQTHPLRDAASA |
| 44 |
336 |
QRNFLERMSQLASEQCDAQPAAHDARLDDRPALRAPQERDAPPLGASDTGSRASGAAKLTELLGVLMSVISASSLDELKQRSDIWNQMSKAAQDNLSRLSDAFQRATDEAKAAADAAEQAAAAAKQAGADAKAADAAVDAAQKRYDDAVKQGLPDDQLQSLKAALEQARQQAGDAHGRADALQADATKKLDAASALATQARACEQQVDDAVNQATQQYGASASLRTPQSPRLSGAAELTAVLGKLQELISSGNVKELESKQKLFTEMQAKREAELQKKSDEYQAQVKKAEEMQ |
Disorder Picture (Computational Results)
Kinase-specific Phosphorylation Sites (Computational Results)
| Position |
Code |
Kinase |
Peptide |
Score |
Cutoff |
| 3 |
S |
CAMK/MAPKAPK/MNK |
*****MSSGVQGGPA |
12 |
5.685 |
| 237 |
S |
CAMK/RAD53/DUN1 |
TKKLDAASALATQAR |
11 |
6.017 |
| 608 |
S |
AGC/PKC/PKCa/PRKCA |
DAGEMQTSTGKLILR |
14.485 |
5.842 |
| 272 |
S |
CMGC/CDK/CDK2/CDC28 |
ASLRTPQSPRLSGAA |
11 |
9.411 |
| 114 |
S |
CAMK/MAPKAPK/MK5/MAPKAPK5 |
GVLMSVISASSLDEL |
11.455 |
6.633 |
| 3 |
S |
TKL/LISK/LIMK |
*****MSSGVQGGPA |
11 |
6 |
| 269 |
T |
Atypical/PIKK/FRAP |
GASASLRTPQSPRLS |
13.194 |
8.145 |
| 90 |
S |
Other/CDC7/CDC7 |
DAPPLGASDTGSRAS |
11 |
9.583 |
| 272 |
S |
CMGC/CDK/CDK2/CDK2 |
ASLRTPQSPRLSGAA |
16.738 |
6.826 |
| 26 |
S |
Other/CDC7 |
HPLRDAASALGTLSP |
15.333 |
9.583 |
| 16 |
Y |
TK/Csk/CTK |
PAAHANAYQTHPLRD |
11 |
10 |
| 272 |
S |
CMGC/MAPK/ERK/FUS3 |
ASLRTPQSPRLSGAA |
11.667 |
3.833 |
| 325 |
Y |
TK/Met/RON |
LQKKSDEYQAQVKKA |
12.75 |
9.3 |
| 302 |
S |
CK1 |
GNVKELESKQKLFTE |
12.007 |
5.313 |
| 272 |
S |
CMGC/MAPK/ERK/Erk2 |
ASLRTPQSPRLSGAA |
22.535 |
4.61 |
| 269 |
T |
CMGC/MAPK/ERK/Erk1 |
GASASLRTPQSPRLS |
16.34 |
10.326 |
| 114 |
S |
CAMK/MAPKAPK/MK5 |
GVLMSVISASSLDEL |
11.455 |
6.633 |
| 338 |
T |
Other/TTK/TTK |
KAEEMQKTMGCIGKI |
59.091 |
47.968 |
| 32 |
S |
CMGC/MAPK/ERK/Erk4 |
ASALGTLSPQAYVDV |
13.333 |
5.7 |
| 32 |
S |
CMGC/MAPK/p38 |
ASALGTLSPQAYVDV |
12.059 |
4.309 |
| 382 |
S |
Other/PEK/PEK/EIF2AK3 |
LAVGDEISRATTGVS |
11 |
6.95 |
| 26 |
S |
CAMK/RAD53/DUN1 |
HPLRDAASALGTLSP |
11 |
6.017 |
| 609 |
T |
AGC/PKC/PKCa/PRKCA |
AGEMQTSTGKLILRN |
14.015 |
5.842 |
| 30 |
T |
Other/TTK/TTK |
DAASALGTLSPQAYV |
51.727 |
47.968 |
| 272 |
S |
CMGC/CDK/CDK5/PHO85 |
ASLRTPQSPRLSGAA |
13.667 |
7.061 |
| 385 |
T |
CK1/CK1/CK1-D/CSNK1D |
GDEISRATTGVSFMD |
16.3 |
8.142 |
| 32 |
S |
CMGC/CDK/CDK4/CDK6 |
ASALGTLSPQAYVDV |
12.833 |
3.967 |
| 56 |
S |
Other/CDC7 |
ERMSQLASEQCDAQP |
12.667 |
9.583 |
| 269 |
T |
CMGC/MAPK/JNK/JNK2 |
GASASLRTPQSPRLS |
38.412 |
6.118 |
| 533 |
T |
Other/TTK/TTK |
NRFEKAGTVMNVGNQ |
67 |
47.968 |
| 269 |
T |
CMGC/MAPK/ERK/Erk2 |
GASASLRTPQSPRLS |
11.235 |
4.61 |
| 2 |
S |
Other/PLK |
******MSSGVQGGP |
12.701 |
8.093 |
| 569 |
Y |
TK/Met/RON |
ADVKEAMYDIKLLGD |
11.25 |
9.3 |
| 504 |
T |
Other/TTK/TTK |
ALGSRTATAMTRMRR |
55.818 |
47.968 |
| 302 |
S |
Other/NEK/NEK11 |
GNVKELESKQKLFTE |
16.667 |
8.933 |
| 188 |
Y |
TK/Csk/CSK |
VDAAQKRYDDAVKQG |
13.889 |
9.741 |
| 607 |
T |
AGC/PKC/PKCa/PRKCA |
SDAGEMQTSTGKLIL |
13.202 |
5.842 |
| 32 |
S |
CMGC/CDK/CDK5/CDK5 |
ASALGTLSPQAYVDV |
11.938 |
7.867 |
| 116 |
S |
Other/CDC7 |
LMSVISASSLDELKQ |
11.667 |
9.583 |
| 308 |
T |
Other/TTK/TTK |
ESKQKLFTEMQAKRE |
48.364 |
47.968 |
| 264 |
S |
Other/CDC7/CDC7 |
ATQQYGASASLRTPQ |
15.333 |
9.583 |
| 325 |
Y |
TK/Src/SrcB/LCK |
LQKKSDEYQAQVKKA |
12.4 |
5.853 |
| 500 |
S |
CK1/TTBK/TTBK1 |
SGLQALGSRTATAMT |
12.25 |
5.133 |
| 293 |
S |
CK1/CK1/CK1-D/CSNK1D |
GKLQELISSGNVKEL |
20.55 |
8.142 |
| 504 |
T |
Other/CDC7/CDC7 |
ALGSRTATAMTRMRR |
12.333 |
9.583 |
| 32 |
S |
CMGC/MAPK/ERK/Erk1 |
ASALGTLSPQAYVDV |
21.764 |
10.326 |
| 32 |
S |
CMGC/MAPK/p38/HOG1 |
ASALGTLSPQAYVDV |
12.8 |
7.46 |
| 302 |
S |
CK1/CK1/CK1-D/CSNK1D |
GNVKELESKQKLFTE |
11.2 |
8.142 |
| 272 |
S |
CMGC/MAPK |
ASLRTPQSPRLSGAA |
14.108 |
4.55 |
| 460 |
S |
Other/CDC7/CDC7 |
SAVKAVASKVIDAMA |
11 |
9.583 |
| 266 |
S |
AGC/PKC/PKCi |
QQYGASASLRTPQSP |
15.75 |
7.442 |
| 90 |
S |
Other/CDC7 |
DAPPLGASDTGSRAS |
11 |
9.583 |
| 97 |
S |
TKL/LISK/LIMK |
SDTGSRASGAAKLTE |
14 |
6 |
| 386 |
T |
TKL/LISK |
DEISRATTGVSFMDK |
11.5 |
3.062 |
| 92 |
T |
AGC/GRK |
PPLGASDTGSRASGA |
12.362 |
6.103 |
| 453 |
S |
Other/CDC7 |
AAAFVGASAVKAVAS |
15.333 |
9.583 |
| 269 |
T |
CMGC/CDK/CDK5 |
GASASLRTPQSPRLS |
15.354 |
6.616 |
| 269 |
T |
CMGC/CDK/CDC2/CDK1 |
GASASLRTPQSPRLS |
13.315 |
4.168 |
| 3 |
S |
TKL/LISK/LIMK/LIMK1 |
*****MSSGVQGGPA |
11 |
6 |
| 269 |
T |
CMGC/MAPK/ERK/Erk4 |
GASASLRTPQSPRLS |
15.333 |
5.7 |
| 294 |
S |
TKL/LISK/LIMK |
KLQELISSGNVKELE |
11 |
6 |
| 2 |
S |
CK1/VRK/VRK2 |
******MSSGVQGGP |
23.5 |
4 |
| 385 |
T |
AGC/DMPK/GEK/DMPK |
GDEISRATTGVSFMD |
11.75 |
4.738 |
| 32 |
S |
CMGC/CDK/CDK5 |
ASALGTLSPQAYVDV |
13.859 |
6.616 |
| 237 |
S |
Other/CDC7/CDC7 |
TKKLDAASALATQAR |
15.333 |
9.583 |
| 302 |
S |
Other/CDC7 |
GNVKELESKQKLFTE |
11 |
9.583 |
| 272 |
S |
CMGC/CDK/CDK5 |
ASLRTPQSPRLSGAA |
20.081 |
6.616 |
| 140 |
S |
Other/PEK/PEK |
KAAQDNLSRLSDAFQ |
13 |
6.95 |
| 504 |
T |
CMGC/DYRK/DYRK2 |
ALGSRTATAMTRMRR |
19.389 |
7.053 |
| 269 |
T |
CMGC/CDK/CDK2/CDC28 |
GASASLRTPQSPRLS |
12.889 |
9.411 |
| 36 |
Y |
TK/PDGFR/KIT |
GTLSPQAYVDVVSAA |
11.75 |
8.15 |
| 600 |
S |
AGC/PKC/PKCa/PRKCB |
AQLMQQMSDAGEMQT |
12.655 |
8.434 |
| 150 |
T |
STE/STE20/MST/MST1 |
SDAFQRATDEAKAAA |
31.161 |
2.612 |
| 150 |
T |
TKL/MLK |
SDAFQRATDEAKAAA |
13.64 |
7.138 |
| 114 |
S |
Other/NEK/NEK11 |
GVLMSVISASSLDEL |
11.333 |
8.933 |
| 269 |
T |
CMGC/CDK/CDK2/CDK2 |
GASASLRTPQSPRLS |
14.738 |
6.826 |
| 97 |
S |
Other/AUR/AurB |
SDTGSRASGAAKLTE |
11.185 |
7.092 |
| 3 |
S |
Other/PLK |
*****MSSGVQGGPA |
11.234 |
8.093 |
| 453 |
S |
Other/CDC7/CDC7 |
AAAFVGASAVKAVAS |
15.333 |
9.583 |
| 272 |
S |
CMGC/MAPK/ERK/Erk4 |
ASLRTPQSPRLSGAA |
11.667 |
5.7 |
| 269 |
T |
CMGC/CDK/CDK5/CDK5 |
GASASLRTPQSPRLS |
16.321 |
7.867 |
| 16 |
Y |
TK/Csk/CSK |
PAAHANAYQTHPLRD |
14.815 |
9.741 |
| 97 |
S |
TKL/LISK/LIMK/LIMK1 |
SDTGSRASGAAKLTE |
14 |
6 |
| 322 |
S |
CAMK/CASK/CASK |
EAELQKKSDEYQAQV |
11.667 |
3.667 |
| 272 |
S |
CMGC/MAPK/JNK/JNK2 |
ASLRTPQSPRLSGAA |
30.235 |
6.118 |
| 382 |
S |
Other/PEK/PEK |
LAVGDEISRATTGVS |
11 |
6.95 |
| 294 |
S |
TKL/LISK/LIMK/LIMK1 |
KLQELISSGNVKELE |
11 |
6 |
| 272 |
S |
Atypical/PIKK/FRAP |
ASLRTPQSPRLSGAA |
13.194 |
8.145 |
| 237 |
S |
Other/CDC7 |
TKKLDAASALATQAR |
15.333 |
9.583 |
| 230 |
T |
Other/TTK/TTK |
DALQADATKKLDAAS |
49.364 |
47.968 |
| 3 |
S |
CK1/VRK/VRK2 |
*****MSSGVQGGPA |
24.75 |
4 |
| 2 |
S |
CAMK/CAMKL/QIK/SIK1 |
******MSSGVQGGP |
15 |
2.597 |
| 264 |
S |
CAMK/RAD53/DUN1 |
ATQQYGASASLRTPQ |
11 |
6.017 |
| 609 |
T |
STE/STE20/MST/MST1 |
AGEMQTSTGKLILRN |
13.935 |
2.612 |
| 502 |
T |
STE/STE20/MST/MST1 |
LQALGSRTATAMTRM |
16.645 |
2.612 |
| 26 |
S |
Other/CDC7/CDC7 |
HPLRDAASALGTLSP |
15.333 |
9.583 |
| 32 |
S |
CMGC/MAPK/JNK/JNK2 |
ASALGTLSPQAYVDV |
32.235 |
6.118 |
| 116 |
S |
Other/CDC7/CDC7 |
LMSVISASSLDELKQ |
11.667 |
9.583 |
| 3 |
S |
CAMK/CAMKL/QIK/SIK1 |
*****MSSGVQGGPA |
11.438 |
2.597 |
| 269 |
T |
CK1/TTBK/TTBK1 |
GASASLRTPQSPRLS |
13 |
5.133 |
| 272 |
S |
CMGC/CDK/CDK5/CDK5 |
ASLRTPQSPRLSGAA |
11.16 |
7.867 |
| 140 |
S |
Other/PEK/PEK/EIF2AK3 |
KAAQDNLSRLSDAFQ |
13 |
6.95 |
| 325 |
Y |
TK/Csk/CTK |
LQKKSDEYQAQVKKA |
14 |
10 |
| 32 |
S |
CMGC/CDK/CDK2/CDC28 |
ASALGTLSPQAYVDV |
13.25 |
9.411 |
| 241 |
T |
Other/TTK/TTK |
DAASALATQARACEQ |
49.545 |
47.968 |
| 203 |
S |
AGC/PKC/PKCi |
LPDDQLQSLKAALEQ |
11.708 |
7.442 |
| 302 |
S |
Other/CDC7/CDC7 |
GNVKELESKQKLFTE |
11 |
9.583 |
| 453 |
S |
CAMK/RAD53/DUN1 |
AAAFVGASAVKAVAS |
11 |
6.017 |
| 322 |
S |
CAMK/CASK |
EAELQKKSDEYQAQV |
11.667 |
3.667 |
| 272 |
S |
CMGC/MAPK/ERK/Erk1 |
ASLRTPQSPRLSGAA |
29.486 |
10.326 |
| 32 |
S |
CK1/TTBK/TTBK1 |
ASALGTLSPQAYVDV |
12.25 |
5.133 |
| 308 |
T |
STE/STE20/PAKA |
ESKQKLFTEMQAKRE |
11.593 |
6.397 |
| 269 |
T |
CMGC/MAPK/ERK/Erk5 |
GASASLRTPQSPRLS |
14.824 |
4.757 |
| 504 |
T |
Other/CDC7 |
ALGSRTATAMTRMRR |
12.333 |
9.583 |
| 264 |
S |
Other/CDC7 |
ATQQYGASASLRTPQ |
15.333 |
9.583 |
| 542 |
S |
Atypical/PIKK/ATR |
MNVGNQVSQAAGGIV |
11.362 |
8.681 |
| 272 |
S |
CMGC/MAPK/p38 |
ASLRTPQSPRLSGAA |
14.689 |
4.309 |
| 460 |
S |
Other/CDC7 |
SAVKAVASKVIDAMA |
11 |
9.583 |
| 325 |
Y |
TK/Csk/CSK |
LQKKSDEYQAQVKKA |
12.444 |
9.741 |
| 56 |
S |
Other/CDC7/CDC7 |
ERMSQLASEQCDAQP |
12.667 |
9.583 |
| 386 |
T |
CMGC/DYRK/DYRK2 |
DEISRATTGVSFMDK |
15.111 |
7.053 |
| 325 |
Y |
TK/Syk/SYK |
LQKKSDEYQAQVKKA |
12.863 |
5 |
| 103 |
T |
STE/STE7/MEK1/MAP2K2 |
ASGAAKLTELLGVLM |
14 |
7 |
* Only the results whose Scores are more than 10 are listed here.
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Pfam Domains (Experimental/Computational Results)
| id |
type |
start |
end |
| T3SSipB |
Pfam |
99 |
261 |
| SseC |
Pfam |
284 |
616 |
Mutation (Experimental Results)
| POSITION |
WILD-TYPE AA |
MUTANT |
DISEASE/NOTES |
REFERENCE |
| Sorry. There is no result for this protein entry. |
Pathway (Experimental Results)
| Pathway Accession Number |
Description |
| Sorry. There is no result for this protein entry. |
Multiple Sequence Alignments (Computational Results)
Protein Alignment (Computational Results)
