Comprehensive Information

Detailed Information (Experimental Results)

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Database ID7
UniProt ID A0FKE5 
Name AexU
Type Type III secretion system effector (T3SE)
Gene Name -
Organism Aeromonas veronii
Gene Ontology Terms GO:0005096
Function -
Sequence MQIQANTVGTQAVAHHSDATTGVGQMGQLEARQVATGQDAILLGNRSEPQKGQGQLSRSESRPARVLAAIKEWIGNLLGSGKSAAAPKVQTATSPEDLQRLMKQAAFGSSLGGFAKADVLNNIAAEQLGKDHATLATGNGPLRSLCTALQAVVVGSEQPQLRELAAGLLARPIAGIPLQQWGTVGGKVTELLASATPELLQEAMSQLHTAMGEVADLQRAVKAEIAGEPAQSATTKADAAPVQSGESKGAAREQVAMARQTPATGYKLALDLISYQASYLLRDQTSTEVTLSSSDLNALHQHIADGSINSSHMAKLQTRGDLQTLRTLALSLASGSDAKGSSLGHALDSLASVRPNQRLVLGGLMQFAGQTEQAWVDHTALKPREERLDAGARLRFDTGHMQAELGRLGDSEARQVLQQLEGAFGDRARAICDFAVAQVSGFADSESSPEAVLVSRLTRMGNLVGSLTDALKERLQLPESARGEPTMIDSVSQLTPLELAALAHIGVDESYL
Length 512  amino acids
Reference 26120140
IBS
There is no IBS picture for this protein entry.
Sequence Alignment:

Protein Structure (Experimental Results)

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PDB Accession Method Resolution Chain Structure Review
Sorry. There is no result for this protein entry.

Disorder Prediction (Computational Results)

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Start End Sequence
382 422 KPREERLDAGARLRFDTGHMQAELGRLGDSEARQVLQQLEG
442 452 FADSESSPEAV
463 488 LVGSLTDALKERLQLPESARGEPTMI
1 99 MQIQANTVGTQAVAHHSDATTGVGQMGQLEARQVATGQDAILLGNRSEPQKGQGQLSRSESRPARVLAAIKEWIGNLLGSGKSAAAPKVQTATSPEDLQ
508 512 DESYL
285 351 TSTEVTLSSSDLNALHQHIADGSINSSHMAKLQTRGDLQTLRTLALSLASGSDAKGSSLGHALDSLA
199 262 LLQEAMSQLHTAMGEVADLQRAVKAEIAGEPAQSATTKADAAPVQSGESKGAAREQVAMARQTP

Disorder Picture (Computational Results)

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Kinase-specific Phosphorylation Sites (Computational Results)

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Position Code Kinase Peptide Score Cutoff
196 T CMGC/MAPK/JNK/JNK2 TELLASATPELLQEA 29.853 6.118
94 S CMGC/CDK/CDK2/CDK2 PKVQTATSPEDLQRL 14.497 6.826
448 S CMGC/MAPK/ERK/FUS3 GFADSESSPEAVLVS 11.333 3.833
94 S CMGC/MAPK/p38 PKVQTATSPEDLQRL 12.37 4.309
480 S AGC/PKC/PKCi ERLQLPESARGEPTM 12.667 7.442
398 T CAMK/PIM/PIM2 GARLRFDTGHMQAEL 11.333 4.333
336 S CMGC/CDK/CDK2/CDC28 ALSLASGSDAKGSSL 12.583 9.411
194 S Other/CDC7 KVTELLASATPELLQ 15.333 9.583
261 T CMGC/DYRK/DYRK1/DYRK1B QVAMARQTPATGYKL 12.667 5.975
318 T STE/STE20/MST SHMAKLQTRGDLQTL 21.842 3.532
196 T STE/STE7/MEK7/MAP2K7 TELLASATPELLQEA 11.167 6.435
91 T STE/STE20/MST AAAPKVQTATSPEDL 52.658 3.532
448 S CMGC/CDK/CDK5/PHO85 GFADSESSPEAVLVS 11.667 7.061
448 S CMGC/MAPK/JNK/JNK3 GFADSESSPEAVLVS 11.562 6.781
511 Y TK/Src/SRM/PTK6 HIGVDESYL****** 11.636 3.491
235 T STE/STE20/MST EPAQSATTKADAAPV 53.447 3.532
261 T CMGC/MAPK/JNK/JNK2 QVAMARQTPATGYKL 34.794 6.118
196 T STE/STE20/MST/MST1 TELLASATPELLQEA 25.161 2.612
510 S AGC/GRK/BARK/BARK1 AHIGVDESYL***** 23.643 3.384
334 S TKL/LISK/LIMK/LIMK1 TLALSLASGSDAKGS 14 6
448 S CMGC/CDK/CDK2/CDC28 GFADSESSPEAVLVS 12.556 9.411
94 S CMGC/CDK/CDK4 PKVQTATSPEDLQRL 15.632 4.463
144 S Atypical/PDHK TGNGPLRSLCTALQA 12.81 2.003
510 S Atypical/PDHK/PDHK AHIGVDESYL***** 22.125 2.805
261 T CMGC/CDK/CCRK/CDK20 QVAMARQTPATGYKL 11 5.888
183 T Other/TTK/TTK IPLQQWGTVGGKVTE 62.091 47.968
144 S Other/CAMKK/Meta/CaMKK2 TGNGPLRSLCTALQA 11.333 5.017
455 S Other/PEK SPEAVLVSRLTRMGN 11.318 2.678
36 T TKL/LISK/LIMK/LIMK1 LEARQVATGQDAILL 11 6
290 T Other/TTK/TTK DQTSTEVTLSSSDLN 53.364 47.968
94 S CMGC/MAPK/ERK/Erk1 PKVQTATSPEDLQRL 15.146 10.326
448 S CMGC/MAPK/JNK/JNK2 GFADSESSPEAVLVS 33.029 6.118
261 T STE/STE20/PAKA/PAK1 QVAMARQTPATGYKL 11.553 6.979
94 S CMGC/MAPK/ERK/FUS3 PKVQTATSPEDLQRL 11.667 3.833
495 T CMGC/MAPK/JNK/JNK2 IDSVSQLTPLELAAL 30.912 6.118
57 S Other/PEK/PEK QKGQGQLSRSESRPA 13 6.95
94 S CMGC/CDK/CDK5/CDK5 PKVQTATSPEDLQRL 11.469 7.867
196 T CMGC/MAPK/ERK/Erk4 TELLASATPELLQEA 11 5.7
510 S Other/PEK AHIGVDESYL***** 15.682 2.678
285 T CAMK/CAMKL/CHK1 SYLLRDQTSTEVTLS 11.207 8.03
341 S CK1/TTBK/TTBK1 SGSDAKGSSLGHALD 12.125 5.133
492 S Atypical/PIKK/ATR PTMIDSVSQLTPLEL 11.362 8.681
334 S TKL/LISK/LIMK TLALSLASGSDAKGS 14 6
352 S AGC/PKC/PKCi HALDSLASVRPNQRL 12.375 7.442
209 T Other/TTK/TTK EAMSQLHTAMGEVAD 52.545 47.968
511 Y TK/PDGFR HIGVDESYL****** 14.101 5.435
261 T CMGC/CDK/CDK2/CDC28 QVAMARQTPATGYKL 15.139 9.411
275 Y TK/Csk/CTK LALDLISYQASYLLR 12 10
448 S CMGC/CDK/CDK5/CDK5 GFADSESSPEAVLVS 15.346 7.867
59 S AGC/GRK/GRK/GRK GQGQLSRSESRPARV 15 6.878
468 T STE/STE7/MEK1/MAP2K2 GNLVGSLTDALKERL 11 7
61 S CAMK/CAMKL/MARK/MARK3 GQLSRSESRPARVLA 12.333 5.383
209 T STE/STE20/PAKA/PAK3 EAMSQLHTAMGEVAD 12.2 5.9
194 S Other/CDC7/CDC7 KVTELLASATPELLQ 15.333 9.583
324 T STE/STE20/MST QTRGDLQTLRTLALS 13.079 3.532
352 S CAMK/MAPKAPK/MNK/MNK1 HALDSLASVRPNQRL 11 8.333
492 S CK1/CK1/CK1-D/CSNK1D PTMIDSVSQLTPLEL 11.35 8.142
286 S AGC/GRK YLLRDQTSTEVTLSS 11.086 6.103
379 T CMGC/CDK/CDK2/CDC28 EQAWVDHTALKPREE 11.722 9.411
480 S Other/CDC7 ERLQLPESARGEPTM 15.333 9.583
61 S AGC/RSK/MSK/RPS6KA5 GQLSRSESRPARVLA 17.222 8.69
196 T CMGC/MAPK/p38 TELLASATPELLQEA 12.319 4.309
61 S CAMK/CAMKL GQLSRSESRPARVLA 14.378 6.355
510 S Other/PLK AHIGVDESYL***** 21.461 8.093
59 S AGC/PKC/PKCa/PRKCB GQGQLSRSESRPARV 11.207 8.434
61 S TKL/RAF/RAF GQLSRSESRPARVLA 13.8 1.232
486 T Other/PLK/PLK2 ESARGEPTMIDSVSQ 11.953 5.114
287 T Other/TTK/TTK LLRDQTSTEVTLSSS 53.091 47.968
57 S Other/PEK/PEK/EIF2AK3 QKGQGQLSRSESRPA 13 6.95
61 S AGC/RSK/RSKp70 GQLSRSESRPARVLA 13.079 3.694
510 S AGC/PKC/PKCa/PRKCA AHIGVDESYL***** 15.687 5.842
94 S CMGC/MAPK/ERK/Erk2 PKVQTATSPEDLQRL 12.509 4.61
261 T CMGC/MAPK/JNK/JNK3 QVAMARQTPATGYKL 11.375 6.781
196 T STE/STE7/MEK7 TELLASATPELLQEA 12.833 7.32
196 T CMGC/CDK/CDK2/CDC28 TELLASATPELLQEA 14.333 9.411
311 S CAMK/MAPKAPK/MNK/MNK2 ADGSINSSHMAKLQT 11.429 6.869
61 S CAMK/MAPKAPK GQLSRSESRPARVLA 24.208 6.36
448 S CMGC/MAPK/p38/MAPK11 GFADSESSPEAVLVS 12.407 5.425
194 S CAMK/RAD53/DUN1 KVTELLASATPELLQ 11 6.017
261 T CMGC/MAPK/ERK/Erk1 QVAMARQTPATGYKL 12.528 10.326
307 S AGC/PKC/PKCi HQHIADGSINSSHMA 12.562 7.442
264 T TKL/LISK/LIMK MARQTPATGYKLALD 11 6
91 T CK1/CK1/CK1-D/CK1e AAAPKVQTATSPEDL 12.294 4.55
247 S Other/CDC7 APVQSGESKGAAREQ 11 9.583
447 S Other/CDC7/CDC7 SGFADSESSPEAVLV 11.667 9.583
447 S Other/CDC7 SGFADSESSPEAVLV 11.667 9.583
495 T CMGC/CDK/CDK2/CDK2 IDSVSQLTPLELAAL 14.141 6.826
137 T TKL/LISK/LIMK/LIMK1 KDHATLATGNGPLRS 11 6
448 S CMGC/MAPK/ERK/Erk1 GFADSESSPEAVLVS 17.41 10.326
196 T CMGC/CDK/CDK4 TELLASATPELLQEA 12.842 4.463
235 T Other/TTK/TTK EPAQSATTKADAAPV 50.727 47.968
189 T STE/STE7/MEK1/MAP2K2 GTVGGKVTELLASAT 11 7
94 S CMGC/CDK/CDK2/CDC28 PKVQTATSPEDLQRL 14.75 9.411
495 T CMGC/MAPK/ERK/Erk1 IDSVSQLTPLELAAL 19.104 10.326
10 T CK1/VRK/VRK2 IQANTVGTQAVAHHS 15.75 4
94 S CMGC/CDK/CDK5 PKVQTATSPEDLQRL 17.232 6.616
247 S Other/CDC7/CDC7 APVQSGESKGAAREQ 11 9.583
327 T Other/TTK/TTK GDLQTLRTLALSLAS 52.636 47.968
264 T TKL/LISK/LIMK/LIMK1 MARQTPATGYKLALD 11 6
495 T CMGC/CDK/CDK5/CDK5 IDSVSQLTPLELAAL 21.21 7.867
7 T CK1/VRK/VRK2 *MQIQANTVGTQAVA 20.5 4
261 T CMGC/MAPK/p38/MAPK11 QVAMARQTPATGYKL 12.074 5.425
234 T CK1/CK1/CK1-D/CSNK1D GEPAQSATTKADAAP 12.35 8.142
205 S CK1/CK1/CK1-D/CSNK1D ELLQEAMSQLHTAMG 11.45 8.142
261 T Other/AUR/AurB QVAMARQTPATGYKL 12.407 7.092
261 T CMGC/CDK/CDK5/PHO85 QVAMARQTPATGYKL 11 7.061
247 S AGC/GRK/GRK/GPRK4 APVQSGESKGAAREQ 11.667 1.617
468 T STE/STE20/MST GNLVGSLTDALKERL 26.868 3.532
94 S CMGC/MAPK/JNK/JNK2 PKVQTATSPEDLQRL 30.853 6.118
510 S AGC/PKC/PKCa/PRKCB AHIGVDESYL***** 13.828 8.434
480 S Other/CDC7/CDC7 ERLQLPESARGEPTM 15.333 9.583
235 T CK1/CK1/CK1-D/CSNK1D EPAQSATTKADAAPV 13.2 8.142
285 T STE/STE20/MST/MST1 SYLLRDQTSTEVTLS 24.194 2.612
490 S CK1/CK1/CK1-D/CSNK1D GEPTMIDSVSQLTPL 14.75 8.142
196 T CMGC/MAPK/ERK/Erk1 TELLASATPELLQEA 19.229 10.326
232 S AGC/GRK/GRK/GRK IAGEPAQSATTKADA 13.667 6.878
398 T CAMK/CAMKL/PASK/PASK GARLRFDTGHMQAEL 11.5 5.4
61 S CMGC/DYRK/DYRK2 GQLSRSESRPARVLA 14.056 7.053
495 T CMGC/CDK/CDK2/CDC28 IDSVSQLTPLELAAL 12.75 9.411
510 S AGC/GRK/BARK AHIGVDESYL***** 15.442 3.806
137 T TKL/LISK/LIMK KDHATLATGNGPLRS 11 6
511 Y TK/Csk/CSK HIGVDESYL****** 15.63 9.741
36 T TKL/LISK/LIMK LEARQVATGQDAILL 11 6
448 S CK1/TTBK/TTBK1 GFADSESSPEAVLVS 14.125 5.133
61 S CAMK/CAMKL/CHK1 GQLSRSESRPARVLA 14.448 8.03

* Only the results whose Scores are more than 10 are listed here.

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Pfam Domains (Experimental/Computational Results)

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id type start end
YopE Pfam 126 195

Mutation (Experimental Results)

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POSITION WILD-TYPE AA MUTANT DISEASE/NOTES REFERENCE
Sorry. There is no result for this protein entry.

Pathway (Experimental Results)

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Pathway Accession Number Description
Sorry. There is no result for this protein entry.

Multiple Sequence Alignments (Computational Results)

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Protein Alignment (Computational Results)

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