Comprehensive Information

Detailed Information (Experimental Results)

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Database ID9
UniProt ID A1JU65 
Name Cysteine protease yopT1
Type Type III secretion system effector (T3SE)
Gene Name yopT1
Organism Yersinia enterocolitica serotype O:8 / biotype 1B
Gene Ontology Terms GO:0005576;GO:0004197;GO:0009405
Function Cysteine protease, which is translocated into infected cells and plays a central role in pathogenesis by cleaving the C- terminus end of the human small GTPase RhoA/ARHA, a regulator of cytoskeleton. Once cleaved, ARHA loses its lipid modification, and is released from the cell membrane, leading to the subsequent disruption of actin cytoskeleton of the host cell (By similarity).
Sequence MDSIHGHYHIQLSNYSAGENLQSATPPEGVIGAHRVKVETALSHSNRQKKLSATIKHNQSSRSMLDRKLTSDGKVNQRSSFTFSMIMYRMIHFVLSTRVPAVRESVANYGGNINFKFAQTKGAFLHQIIKHSDTARGACEALCAHWIRSHAQGQSLFDQLYVGGRKGKFQIDTLYSIKQLQIDGCKADVDQDEVTLDWLKKNGISERMIERHCLLPTVDVTGTTGSEGPDQLLNAILDTNGIGYGYKKISLSGQMSGHTIAAYVNENSGVTFFDPNFGEFHFSDKEKFSKWFTNSFWENSMYHYPLGVGQSFSVFTFDSKEV
Length 322  amino acids
Reference 24391954
IBS
There is no IBS picture for this protein entry.
Sequence Alignment:

Protein Structure (Experimental Results)

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PDB Accession Method Resolution Chain Structure Review
Sorry. There is no result for this protein entry.

Disorder Prediction (Computational Results)

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Start End Sequence
284 288 DKEKF
37 79 KVETALSHSNRQKKLSATIKHNQSSRSMLDRKLTSDGKVNQRS
1 6 MDSIHG
16 28 SAGENLQSATPPE
222 228 GTTGSEG
250 254 SLSGQ
317 322 FDSKEV

Disorder Picture (Computational Results)

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Kinase-specific Phosphorylation Sites (Computational Results)

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Position Code Kinase Peptide Score Cutoff
52 S AGC/PKC/PKCh SNRQKKLSATIKHNQ 13.744 4.771
25 T CMGC/MAPK/JNK/JNK2 GENLQSATPPEGVIG 30.441 6.118
16 S CK1/VRK/VRK2 HIQLSNYSAGENLQS 12 4
311 S AGC/PKC/PKCa/PRKCA YPLGVGQSFSVFTFD 12.157 5.842
54 T STE/STE20/MST RQKKLSATIKHNQSS 17.289 3.532
40 T Other/CDC7 AHRVKVETALSHSNR 12.333 9.583
195 T Other/TTK/TTK DVDQDEVTLDWLKKN 54.545 47.968
25 T CMGC/MAPK/ERK/Erk2 GENLQSATPPEGVIG 13.925 4.61
263 Y TK/PDGFR/KIT SGHTIAAYVNENSGV 11.75 8.15
195 T CK1/CK1/CK1-D/CSNK1D DVDQDEVTLDWLKKN 11.75 8.142
246 Y TK/Jak/JAK2 TNGIGYGYKKISLSG 11.818 9.766
25 T CMGC/CDK/CDK2/CDC28 GENLQSATPPEGVIG 15.278 9.411
256 S CMGC/CDK/CDK4/CDK6 ISLSGQMSGHTIAAY 11.167 3.967
61 S Other/NEK/NEK11 TIKHNQSSRSMLDRK 11 8.933
71 S AGC/AKT/AKT2 MLDRKLTSDGKVNQR 11.357 6.504
316 T Atypical/PDHK/PDHK GQSFSVFTFDSKEV* 21.25 2.805
313 S AGC/GRK/BARK/BARK1 LGVGQSFSVFTFDSK 14.667 3.384
79 S AGC/RSK/RSKp90/RPS6KA3 DGKVNQRSSFTFSMI 11.118 8.112
52 S CAMK/DAPK/DAPK SNRQKKLSATIKHNQ 15.878 3.493
263 Y TK/Eph SGHTIAAYVNENSGV 11.146 7.03
302 Y TK/Eph/EphB1 SFWENSMYHYPLGVG 14.667 7.967
52 S STE/STE20/PAKA SNRQKKLSATIKHNQ 12.151 6.397
295 S STE/STE20/YSK FSKWFTNSFWENSMY 13 6.05
302 Y TK/Src/SrcB/HCK SFWENSMYHYPLGVG 12.8 6.378
313 S AGC/GRK/BARK LGVGQSFSVFTFDSK 13.07 3.806
223 T Other/TTK/TTK PTVDVTGTTGSEGPD 53.545 47.968
13 S CK1/VRK/VRK2 GHYHIQLSNYSAGEN 13.75 4
311 S Atypical/PDHK/PDHK YPLGVGQSFSVFTFD 22.175 2.805
52 S AGC/DMPK/ROCK SNRQKKLSATIKHNQ 15.242 6.326
70 T CAMK/MAPKAPK SMLDRKLTSDGKVNQ 14.857 6.36
25 T CMGC/MAPK/ERK/Erk1 GENLQSATPPEGVIG 18.174 10.326
70 T AGC/PKG/PRKG1 SMLDRKLTSDGKVNQ 11.6 6.847
52 S STE/STE20/PAKA/CLA4 SNRQKKLSATIKHNQ 13.625 3.825
316 T AGC/GRK/BARK/BARK1 GQSFSVFTFDSKEV* 20.071 3.384
43 S CAMK/MAPKAPK/MK5/MAPKAPK5 VKVETALSHSNRQKK 11.091 6.633
316 T Other/NEK/NEK11 GQSFSVFTFDSKEV* 13.667 8.933
25 T CMGC/CDK/CDK2/CDK2 GENLQSATPPEGVIG 11.06 6.826
311 S AGC/GRK/BARK/BARK1 YPLGVGQSFSVFTFD 11.762 3.384
316 T AGC/PKC/PKCa/PRKCA GQSFSVFTFDSKEV* 14.677 5.842
43 S CAMK/MAPKAPK/MK5 VKVETALSHSNRQKK 11.091 6.633
295 S Atypical/PDHK/PDHK FSKWFTNSFWENSMY 25.825 2.805
313 S AGC/PKC/PKCa/PRKCA LGVGQSFSVFTFDSK 11.328 5.842
70 T CMGC/DYRK/DYRK2 SMLDRKLTSDGKVNQ 11.556 7.053
3 S CK1/VRK/VRK2 *****MDSIHGHYHI 22 4
80 S Other/AUR/AurB GKVNQRSSFTFSMIM 12.185 7.092
120 T Other/Haspin/Haspin INFKFAQTKGAFLHQ 11 7
319 S AGC/GRK/BARK/BARK1 FSVFTFDSKEV**** 23.357 3.384
268 S Other/NEK/NEK11 AAYVNENSGVTFFDP 14.333 8.933
319 S AGC/GRK/BARK FSVFTFDSKEV**** 12.744 3.806
173 T STE/STE20/TAO KGKFQIDTLYSIKQL 11 6.1
295 S TKL/MLK FSKWFTNSFWENSMY 11.76 7.138
289 S Other/PLK FSDKEKFSKWFTNSF 11.357 8.093
176 S AGC/DMPK/ROCK FQIDTLYSIKQLQID 11.823 6.326
71 S CAMK/CAMKL/QIK/SIK2 MLDRKLTSDGKVNQR 11.333 5.721
3 S AGC/PKC/PKCi *****MDSIHGHYHI 14.5 7.442
80 S Atypical/PDHK/PDHK GKVNQRSSFTFSMIM 17 2.805
82 T Atypical/PDHK/PDHK VNQRSSFTFSMIMYR 13.75 2.805
70 T Other/TTK/TTK SMLDRKLTSDGKVNQ 50.909 47.968
105 S STE/STE20/PAKA/PAK1 RVPAVRESVANYGGN 12.132 6.979
313 S Other/NEK/NEK11 LGVGQSFSVFTFDSK 26.333 8.933
3 S CK1/CK1/CK1-D/CSNK1D *****MDSIHGHYHI 12.95 8.142
25 T STE/STE7/MEK7 GENLQSATPPEGVIG 12.833 7.32
120 T Other/Haspin INFKFAQTKGAFLHQ 11 7
71 S CMGC/CDK/CDK2/CDC28 MLDRKLTSDGKVNQR 12.111 9.411
40 T STE/STE20/MST/MST1 AHRVKVETALSHSNR 26.903 2.612
40 T Other/CDC7/CDC7 AHRVKVETALSHSNR 12.333 9.583
52 S AGC/PKC/PKCa/PRKCB SNRQKKLSATIKHNQ 12.155 8.434
319 S AGC/PKC/PKCa/PRKCA FSVFTFDSKEV**** 15.283 5.842
25 T CMGC/CDK/CDK5/CDK5 GENLQSATPPEGVIG 15.926 7.867
316 T CAMK/RAD53/CHK2 GQSFSVFTFDSKEV* 11.386 4.788
173 T STE/STE20/TAO/TAOK1 KGKFQIDTLYSIKQL 11 6.1
283 S Other/NEK/NEK11 NFGEFHFSDKEKFSK 19.667 8.933
60 S CAMK/MAPKAPK/MNK/MNK2 ATIKHNQSSRSMLDR 11.571 6.869
25 T Atypical/PIKK/FRAP GENLQSATPPEGVIG 19.167 8.145
259 T CK1/TTBK/TTBK1 SGQMSGHTIAAYVNE 12.625 5.133
25 T STE/STE7/MEK7/MAP2K7 GENLQSATPPEGVIG 11.167 6.435

* Only the results whose Scores are more than 10 are listed here.

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Pfam Domains (Experimental/Computational Results)

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id type start end
Peptidase_C58 Pfam 103 320

Mutation (Experimental Results)

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POSITION WILD-TYPE AA MUTANT DISEASE/NOTES REFERENCE
Sorry. There is no result for this protein entry.

Pathway (Experimental Results)

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Pathway Accession Number Description
Sorry. There is no result for this protein entry.

Multiple Sequence Alignments (Computational Results)

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Protein Alignment (Computational Results)

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